Muscle and bone network system induced by mechanical factors
| Project/Area Number |
15K08220
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Environmental physiology(including physical medicine and nutritional physiology)
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| Research Institution | Kindai University |
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Principal Investigator |
KAJI Hiroshi 近畿大学, 医学部, 教授 (90346255)
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| Co-Investigator(Kenkyū-buntansha) |
河尾 直之 近畿大学, 医学部, 講師 (70388510)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 骨格筋 / 骨 / メカニカルストレス / 重力 / 前庭系 / フォリスタチン / 骨粗鬆症 / アイリシン / 前庭 / 筋 / マイオスタチン / ビタミンD / 前庭神経 |
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| Outline of Final Research Achievements |
The interactions between skeletal muscle and bone (muscle/bone relationships) have been recently noted. We investigated the influences of mechanical factors on muscle/bone relationships using the comprehensive gene analysis in mice. Our studies indicated the following conclusions: 1. Gravity change affects muscle and bone volume through the vestibular system. 2. Follistatin is involved in the effects of gravity change on muscle and bone as a humoral factor from muscle tissues. 3. Mechanical stress increases bone mineral density through the enhancement of irisin production from muscle.
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Report
(4 results)
Research Products
(14 results)
