Study of Cardioprotective Signal through STAT3/Pim Kinase
Project/Area Number |
15K08232
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
General pharmacology
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Research Institution | Osaka University |
Principal Investigator |
Makiko Maeda 大阪大学, 薬学研究科, 准教授 (70461168)
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Co-Investigator(Kenkyū-buntansha) |
藤尾 慈 大阪大学, 薬学研究科, 教授 (20359839)
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Project Period (FY) |
2015-04-01 – 2018-03-31
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Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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Keywords | 虚血性心疾患 / 心筋保護シグナル / Pim-1キナーゼ / 心筋細胞 / STAT3 / N-cadherin / Il-6ファミリーサイトカイン / Pim-1 |
Outline of Final Research Achievements |
Cardioprotective effect is known to be very important to maintain cardiac homeostasis. Silvestrol, a naturally occurring member of the flavagline family of compounds, inhibits cap-dependent translation by targeting eIF4A, and it is known to decrease the expression of cancer genes. It is also reported that eIF4 family has cell protective effects and eIF4B, exhibits various kinds of biological functions. In cancer cells, eIF4B is activated by Pim-1 kinase. However, pathophysiological roles of Pim-1/eIF4B remain to be elucidated in cardiomyocytes. In this study, we focused on N-cadherin, which is involved in cell-cell adhesion, and proved whether STAT3/Pim-1/eIF4B/ N-cadherin signaling pathway in cardiomyocytes could work for cardioprotective effects. The proposal from the results of this study may support the possibility of cardioprotective effect by cell-cell adhesion control through STAT3/Pim-1 signaling pathway.
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Report
(4 results)
Research Products
(25 results)
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[Journal Article] 2-aminoethoxydiphenyl borate provides an anti-oxidative effect and mediates cardioprotection during ischemia reperfusion in mice.2017
Author(s)
Morihara H, Obana M, Tanaka S, Kawakatsu I, Tsuchiyama D, Mori S, Suizu H, Ishida A, Kimura R, Tsuchimochi I, Maeda M, Yoshimitsu T, Fujio Y, Nakayama H.
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Journal Title
PLoS One.
Volume: 12
Pages: e0189948
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Phospholamban Inhibition by a Single Dose of Locked Nucleic Acid Antisense Oligonucleotide Improves Cardiac Contractility in Pressure Overload-Induced Systolic Dysfunction in Mice.2017
Author(s)
Morihara H, Yamamoto T, Oiwa H, Tonegawa K, Tsuchiyama D, Kawakatsu I, Obana M, Maeda M, Mohri T, Obika S, Fujio Y, Nakayama H.
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Journal Title
J Cardiovasc Pharmacol Ther
Volume: 22(3)
Pages: 273-282
DOI
Related Report
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[Journal Article] Caveolae-specific activation loop between CaMKII and L-type Ca2+ channel aggravates cardiac hypertrophy in α1 adrenergic stimulation.2017
Author(s)
Tonegawa K, Otsuka W, Kumagai S, Matsunami S, Hayamizu N, Tanaka S, Moriwaki K, Obana M, Maeda M, Asahi M, Kiyonari H, Fujio Y, Nakayama H.
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Journal Title
Am J Physiol Heart Circ Physiol.
Volume: 312(3)
Pages: H501-H514
DOI
Related Report
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[Journal Article] Four cases of investigational therapy with interleukin-11 against acute myocardial infarction.2016
Author(s)
Nakagawa M, Owada Y, Izumi Y, Nonin S, Sugioka K, Nakatani D, Iwata S, Mizutani K, Nishimura S, Ito A, Fujita S, Daimon T, Sawa Y, Asakura M, Maeda M, Fujio Y, Yoshiyama M.
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Journal Title
Heart Vessels.
Volume: 31(9)
Pages: 1574-1578
DOI
Related Report
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[Journal Article] Moesin is activated in cardiomyocytes in experimental autoimmune myocarditis and mediates cytoskeletal reorganization with protrusion formation.2016
Author(s)
Miyawaki A, Mitsuhara Y, Orimoto A, Nakayasu Y, Tsunoda S, Obana M, Maeda M, Nakayama H, Yoshioka Y, Tsutsumi Y, Fujio Y.
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Journal Title
Am J Physiol Heart Circ Physiol.
Volume: 1:311(2)
Pages: H476-486.
DOI
Related Report
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[Journal Article] Four cases of investigational therapy with interleukin-11 against acute myocardial infarction.2016
Author(s)
Nakagawa, M., Owada Y., Izumi, Y., Nonin, S., Sugioka, K., Iwata, S., Mizutani, K., Nishimura, S., It, A., Fujita, S., Daimon, T., Sawa, Y., Asakura, M., Maeda, M., Fujio, Y., Yoshiyama, M.
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Journal Title
Heart and Vessels
Volume: in press
Pages: 未定
Related Report
Peer Reviewed / Open Access
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[Journal Article] Vascular functional and morphological alteration in smokers during varenicline therapy.2015
Author(s)
Kobayashi, M., Takemoto, Y., Norioka, N., Iguchi, Y., Shimada, K., Maeda, M., Morimura, M., Fujio, Y., Azuma, ., Yoshiyama, M., Hirohashi, K., Shuto, T.
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Journal Title
Osaka City Med. J.
Volume: 61
Pages: 19-30
Related Report
Peer Reviewed
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[Journal Article] Cardiac specific ablation of STAT3 gene in subacute phase of myocardial infarction exacerbated cardiac remodeling.2015
Author(s)
Enomoto, D., Obana, M., Miyawaki, A., Maeda, M., Nakayama, H., Fujio, Y.
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Journal Title
Am. J. Physiol. Heart Circ. Physiol.
Volume: 309
Pages: H471-480
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] Moesinは実験的自己免疫性心筋炎モデルにおいて活性化し、仮足形成を伴う組織修復に関与する(Moesin is activated in cardiomyocytes in experimental autoimmune myocarditis and mediates tissue restoration with protrusion formation)2017
Author(s)
Yusuke Mitsuhara, Akimitsu Miyawaki, Aya Orimoto, Yusuke Nakayasu, Shin-ichi Tsunoda, Masanori Obana, Makiko Maeda, Hiroyuki Nakayama, Yasuo Yoshioka, Yasuo Tsutsumi, Yasushi Fujio
Organizer
第90回日本薬理学会年会
Place of Presentation
長崎ブリックホール
Year and Date
2017-03-15 – 2017-03-15
Related Report
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[Presentation] Safety and feasibility report of investigational therapy with interleukin-11 against acute myocardial infarction2017
Author(s)
Maeda, M., Nakagawa, M., Owada, Y., Izumi, Y., Nonin, S., Sugioka, K., Nakatani, D., Iwata,S., Mizutani, K., Nishimura, S., Ito, A., Fujita, S., Daimon, T., Sawa, Y., Asakura, M., Fujio, Y., Yoshiyama, M.
Organizer
American Heart Association Scientific Sessions 2017
Related Report
Int'l Joint Research
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[Presentation] Myofibroblast-specific deletion of Runx2 improves systolic function and survival in late phase of cardiac remodeling after myocardial infarction2017
Author(s)
Tanaka, S., Enomoto, D., Yanase, E., Kumagi, S., Obana, M., Maeda, M., Fujio, Y., Nakayama, H.
Organizer
AHA Scientific Sessions 2017
Related Report
Int'l Joint Research
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[Presentation] Adult mammalian hearts restore intrinsic regenerative capacity through signal transducer and activator of transcription 3 in the resolution phase of myocarditis.2016
Author(s)
Akimitsu Miyawaki, Masanori Obana, Yusuke Mitsuhara, Aya Orimoto, Yusuke Nakayasu, Tomomi Yamashita, So-ichiro Fukada, Makiko Maeda, Yasushi Sakata, Hiroyuki Nakayama, Yasushi Fujio
Organizer
American Heart Association Scientific Session 2016
Place of Presentation
New Orleans.USA
Year and Date
2016-11-13 – 2016-11-13
Related Report
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[Presentation] Cardiac STAT3 activation in subacute phase of myocardial infarction was required for the suppression of adverse cardiac remodeling2015
Author(s)
Enomoto, D., Obana, M., Miyawaki, A., Maeda, m., Nakayama,H., Fujio, Y.
Organizer
American Heart Association Scientific Sessions 2015
Place of Presentation
Orlando
Year and Date
2015-11-07 – 2015-11-11
Related Report
Int'l Joint Research
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