| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
A novel non-alcoholic steatohepatitis (NASH) model was developed to clarify the role of chymase on metabolic syndrome-derived NASH in spontaneously hypertensive rats fed a high-fat and high-cholesterol diet. In the NASH model, hepatic chymase level was significantly increased, but chymase inhibitor attenuated the development and progression of NASH, resulted in a significant increase of survival rate. A novel hamster metabolic syndrome-derived NASH model was also developed in hamsters fed a high-fat and high-cholesterol diet. In this model, a significant increase of hepatic chymase was also observed.
Chymase played an important role in the development and progression of metabolic syndrome-derived NASH.
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