| Project/Area Number |
15K08268
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General medical chemistry
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| Research Institution | Kyoto University |
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Principal Investigator |
Suno Ryoji 京都大学, 医学研究科, 特定助教 (60447521)
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| Co-Investigator(Kenkyū-buntansha) |
野村 紀通 京都大学, 医学研究科, 助教 (10314246)
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| Co-Investigator(Renkei-kenkyūsha) |
KOBAYASHI Takuya 京都大学, 医学研究科, 准教授 (20311730)
Yanagisawa Masashi 筑波大学, 国際統合睡眠医科学研究機構, 教授 (20202369)
Saitoh Tsuyoshi 筑波大学, 国際統合睡眠医科学研究機構, 助教 (80609933)
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| Research Collaborator |
Kobilka Brian K スタンフォード大学, 医学部, 教授
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | ヒト膜受容体 / GPCR / シグナル伝達 / X線結晶構造解析 / 抗体 / 薬剤開発 / ナルコレプシー / 睡眠 / 機能性抗体 / 膜タンパク質 / 創薬 |
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| Outline of Final Research Achievements |
Our goal is to determine the active and inactive crystal structures of OX1R and OX2R. We determined the structure of the selective antagonist EMPA-bound OX2R, and revealed the molecular mechanism of the selectivity of EMPA in detail. As the three-dimensional structure of OX1R and OX2R became clear, it was possible to provide useful information for drug development based on structural information. In addition, various tertiary structure-recognizing antibodies can be obtained during the research period, and one of them has been a functional antibody that inhibits signal transduction up to now. In the future, structure determination of active OX2R is expected as a part of research aimed at developing therapeutic drug for narcolepsy.
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