Tissue-specific function of VDR on colitis and colitic cancer

• Project/Area Number: 15K08298
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Pathological medical chemistry
• Research Institution: The University of Tokyo
• Principal Investigator: YAMAMOTO YOKO 東京大学, 医学部附属病院, 助教 (30376644)
• Co-Investigator(Kenkyū-buntansha): 渡邉 聡明 東京大学, 医学部附属病院, 教授 (80210920)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2016: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000); Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: VDR / 大腸癌 / 炎症性腸疾患 / ビタミンD / 遺伝子欠損マウス / ビタミンD受容体 / 大腸

Outline of Final Research Achievements

The present study investigated biological functions of vitamin D receptor (VDR) on colitis and colitic cancer. Colon epithelium-specific VDRKO mice were generated with CDX2P-CreERT2 transgenic mice and VDR flox mice. Although colon epithelium-specific VDRKO mice with colitic cancer had worse overall survival than control mice with colitic cancer, no differences were observed in colitis or colitic cancer specific phenotypes between colon epithelium-specific VDRKO and control mice, since decreased expression of Vdr gene in colon of control mice treated with DSS or AOM/DSS was observed.

Research Products

• [Journal Article] Hereditary gastrointestinal cancer. (2016)
  • Author(s): Hata K, Yamamoto Y, Kiyomatsu T, Tanaka T, Kazama S, Nozawa H, Kawai K, Tanaka J, Nishikawa T, Otani K, Yasuda K, Kishikawa J, Nagai Y, Anzai H, Shinagawa T, Arakawa K, Yamaguchi H, Ishihara S, Sunami E, Kitayama J, Watanabe T.
  • Journal Title: Surg Today. Volume: 印刷中 Issue: 10 Pages: 1115-1122
  • DOI: 10.1007/s00595-015-1283-3
  • Peer Reviewed / Open Access
• [Journal Article] The phenotype and function of murine bone marrow-derived dendritic cells is not affected by the absence of VDR or its ability to bind 1α,25-dihydroxyvitamin D3. (2016)
  • Author(s): Vanherwegen AS, Ferreira GB, Smeets E, Yamamoto Y, Kato S, Overbergh L, Gysemans C, Mathieu C.
  • Journal Title: J Steroid Biochem Mol Biol. Volume: 印刷中 Pages: 239-245
  • DOI: 10.1016/j.jsbmb.2015.08.010
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Effect of a transcriptional inactive or absent vitamin D receptor on beta-cell function and glucose homeostasis in mice. (2016)
  • Author(s): Vangoitsenhoven R, Wolden-Kirk H, Lemaire K, Verstuyf A, Verlinden L, Yamamoto Y, Kato S, Van Lommel L, Schuit F, Van der Schueren B, Mathieu C, Overbergh L.
  • Journal Title: J Steroid Biochem Mol Biol. Volume: 印刷中 Pages: 309-317
  • DOI: 10.1016/j.jsbmb.2016.02.011
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] High RAD54B expression: an independent predictor of postoperative distant recurrence in colorectal cancer patients. (2015)
  • Author(s): Nagai Y, Yamamoto Y, Yasuhara T, Hata K, Nishikawa T, Tanaka T, Tanaka J, Kiyomatsu T, Kawai K, Nozawa H, Kazama S, Yamaguchi H, Ishihara S, Sunami E, Yamanaka T, Miyagawa K, Watanabe T.
  • Journal Title: Oncotarget Volume: 6 Issue: 25 Pages: 21064-21073
  • DOI: 10.18632/oncotarget.4222
  • Peer Reviewed / Open Access