| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
We examined pathologic involvement and prion protein (PrP) deposition of the olfactory bulb and the olfactory mucosa in 11 autopsied cases of MM1-type sporadic Creutzfeldt-Jakob disease (CJD). In the olfactory bulb, spongiform change was not so apparent and the number of neurons was preserved. PrP immunostaining revealed synaptic-type PrP deposition, particularly in the glomerulus, granular cell layer, mitral cell layer, and anterior olfactory nucleus. Consistent PrP deposition from the early disease stage to the prolonged disease stage was recognized. The olfactory mucosa also showed PrP immunoreactivity. These pathologic findings indicated the resistance of these regions to the progression of prion disease pathology. Western blot analysis of the olfactory bulb showed type 1 PrP band pattern in five examined cases.
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