Pathogenesis of lung adenocarcinoma based on lung fibrosis
| Project/Area Number |
15K08372
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Human pathology
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| Research Institution | Japanese Foundation for Cancer Research |
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Principal Investigator |
Matsubara Osamu 公益財団法人がん研究会, がん研究所 病理部, 研究員 (40107248)
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| Co-Investigator(Kenkyū-buntansha) |
石川 雄一 公益財団法人がん研究会, がん研究所 病理部, 部長 (80222975)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
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| Keywords | 肺腺癌 / 異型腺腫様過形成 / 上皮内腺癌 / 微小浸潤性腺癌 / 置換型腺癌 / 肺線維症 / 間質性肺炎 / 肺胞の細気管支化 / 肺線がん / adenocarcinoma in situ / 異型腺腫様増生 |
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| Outline of Final Research Achievements |
We consider that progressive steps of lung adenocarcinoma may start from proliferation of bronchiolar epitheli, to atypical adenomatous hyperplasia (AAH), adenocarcinoma in situ (AIS), to minimally invasive adenocarcinoma, finally to lepidic pattern adenocarcinoma, and examined and compared the clinic-pathological features of resected operation materials of lung adenocarcinoma with lung fibrosis/interstitial pneumonia and without lung fibrosis/interstitial pneumonia. Of over all the materials of lung adenocarcinoma, lung fibrosis/interstitial pneumonia was found in 20.6%, AAH in 23.6%, multiple cancers in 13.2%, and bronchiolization of alveoli in 23.5%. AAH and bronchiolization of alveoli were significantly more observed in lung adenocarcinoma with lung fibrosis/interstitial pneumonia. This finding suggest lung fibrosis and bronchiolization of alveoli may have an important role.
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Report
(4 results)
Research Products
(19 results)
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[Journal Article] Hypersensitivity Pneumonitis A Perspective From Members of the Pulmonary Pathology Society2018
Author(s)
Miller R, Allen TC, Barrios RJ, Beasley MB, Burke L, Cagle PT, Capelozzi VL, Ge Y, Hariri LP, Kerr KM, Khoor A, Larsen BT, Mark EJ, Matsubara O, Mehrad M, Mino-Kenudson M, Raparia K, Roden AC, Russell P, Schneider F, Sholl LM, Smith ML
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Journal Title
Arch Pathol Lab Med
Volume: 142(1)
Issue: 1
Pages: 120-126
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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