Role of fatty acid binding protein 4 (FABP4) as an exogenous ligand, on growth of prostate cancer cells
| Project/Area Number |
15K08403
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Experimental pathology
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| Research Institution | The University of Tokushima |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
高橋 徹行 武蔵野大学, 付置研究所, 講師 (00403692)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 前立腺癌 / 肥満 / FABP4 / LSR / prostate cancer / 骨転移 |
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| Outline of Final Research Achievements |
Epidemiologically, obesity is known to be associated with prostate cancer development. In order to investigate its mechanism, we focused on Fatty acid binding protein 4 (FABP 4) which is one of adipokines. In this study, it was revealed that FABP4 is involved in activation of PI3K / Akt pathway and cell proliferation by interaction with lipolysis stimulated lipoprotein receptor present on the cell membrane of prostate cancer cells.
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Report
(4 results)
Research Products
(3 results)
