Role of fatty acid binding protein 4 (FABP4) as an exogenous ligand, on growth of prostate cancer cells

Research Project

Project/Area Number	15K08403
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Experimental pathology
Research Institution	The University of Tokushima
Principal Investigator	UEHARA Hisanori 徳島大学, 病院, 教授 (30263809)
Co-Investigator(Kenkyū-buntansha)	高橋徹行武蔵野大学, 付置研究所, 講師 (00403692)
Project Period (FY)	2015-04-01 – 2018-03-31
Project Status	Completed (Fiscal Year 2017)
Budget Amount *help	¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000) Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000) Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000) Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords	前立腺癌 / 肥満 / FABP4 / LSR / prostate cancer / 骨転移
Outline of Final Research Achievements	Epidemiologically, obesity is known to be associated with prostate cancer development. In order to investigate its mechanism, we focused on Fatty acid binding protein 4 (FABP 4) which is one of adipokines. In this study, it was revealed that FABP4 is involved in activation of PI3K / Akt pathway and cell proliferation by interaction with lipolysis stimulated lipoprotein receptor present on the cell membrane of prostate cancer cells.

Report

(4 results)