| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
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| Outline of Final Research Achievements |
Self-reactive regulatory T cells are essential to maintain the immune tolerance. In this study, I searched which processes in immune response should be controlled by regulatory T cells using simulations and mathematical modeling of T cell immune response. The results indicate that simple reduction of proliferation probability of T cells by regulatory T cells is not sufficient for the robust tolerance. Augmentation of interaction between T cells and antigen-presenting cells is essential to stabilize the tolerance. Further, the theoretical prediction provides novel perturbations to enhance immune responses in autoimmune diabetes mice model and in allogeneic T cell response. Thus, I propose a potential landscape model in immune regulation that stable tolerance proceeds to immune response or proliferation of specific T cells through transient fluctuating states by controlling the total amount of interaction between antigen-presenting cells and T cells.
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