| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
Oxidation of low-density lipoproteins (LDLs) is one of the risk factor for developing cardiovascular disease. Recently, we reported that the elastic modulus of oxidized LDLs decreased with increasing oxidation level of the LDL. However, the mechanisms of the decrease of the elastic modulus have not been well investigated. We thought that the structure change of the LDL might contributed to the decrease. This study measured the elastic modulus of LDLs before and after proteases, phospholipase A2. Although the enzyme treatment did not change the elastic modulus, treatment with PLA2 decreased the elastic modulus. Results suggest that structure change of the lipid structure of the LDL might contribute to the decreasing of the elastic modulus. We also investigated the relation between the age and the distribution of the LDL. Although detail more work will be required, we found that the elastic modulus tend to increase with increasing the age.
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