| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
Non-alcoholic steatohepatitis (NASH) is drived from metabolic syndrome and simultaneously have a risk to complicate chronic kidney disease. In this study, imaging mass spectrometry (IMS) and conventional liquid-chromatography mass spectrometry (LC/MS) were used for analysis of lipid species on the kidney in NASH model mice. In the results, IMS revealed the specific distribution of molecular species at m/z 1,400-1,500 on the cortex of kidney section in NASH model mice and LC/MS identified these molecular species as cardiolipin with different fatty acids. Cardiolipin is known as a target by oxidative stress because of having four polyunsaturated fatty acids. The comparison with human pathologic specimen about cardiolipn as a molecular marker would be useful for a novel development of treatment and drug.
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