Role of tumor-derived semaphorin 3A in the development of cancer pain
| Project/Area Number |
15K08682
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pain science
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| Research Institution | Nigata University of Phermacy and Applied Life Sciences |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
山田 大祐 新潟薬科大学, 薬学部, 助手 (50733680)
川原 浩一 新潟薬科大学, 薬学部, 准教授 (10347015)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | セマフォリン3A / がん性疼痛 / mTOR / がん幹細胞 / 薬剤抵抗性 / セマフォリン / miRNA / 腫瘍細胞 / 骨転移腫瘍 / 骨痛 / 骨芽細胞 |
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| Outline of Final Research Achievements |
Elucidation of potential therapeutic targets for bone cancer pain would contribute to relief of the intractable and unbearable pain. We used microarray analysis to reveal upregulation of semaphorin 3A (Sema3A) in the model mice for bone cancer pain. Knockdown of Sema3A and inhibition of Sema3A cellular signaling attenuated the tumor growth and the development of the pain. These results suggest that Sema3A is a potential therapeutic target molecule for the development of bone cancer pain.
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Report
(4 results)
Research Products
(14 results)
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[Journal Article] The Novel Monoclonal Antibody 9F5 Reveals Expression of a Fragment of GPNMB/Osteoactivin Processed by Furin-like Protease(s) in a Subpopulation of Microglia in Neonatal Rat Brain2016
Author(s)
Kawahara K, Hirata H, Ohbuchi K, Nishi K, Maeda A, Kuniyasu A, Yamada D, Maeda T, Tsuji A, Sawada M, Nakayama H.
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Journal Title
Glia
Volume: 64
Issue: 11
Pages: 1938-1961
DOI
NAID
URL
Related Report
Peer Reviewed / Open Access
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