Novel strategy for diabetes using rare sugar

• Project/Area Number: 15K08769
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Hygiene and public health
• Research Institution: University of Toyama
• Principal Investigator: Inadera Hidekuni 富山大学, 大学院医学薬学研究部(医学), 教授 (10301144)
• Co-Investigator(Kenkyū-buntansha): 崔 正国 富山大学, 大学院医学薬学研究部(医学), 助教 (90572115)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 糖尿病 / 希少糖

Outline of Final Research Achievements

We have investigated the thrapeutic possibility of rare sugar psicose for treatment with type 2 diabetes. Our results suggested that psicose can be a novel therapeutic method for treatment of type 2 diabetes.

Research Products

• [Journal Article] Baicalin Augments Hyperthermia-Induced Apoptosis in U937 Cells and Modulates the MAPK Pathway via ROS Generation (2018)
  • Author(s): Zakki Shahbaz?Ahmad、Cui Zheng-Guo、Sun Lu、Feng Qian-Wen、Li Meng-Ling、Inadera Hidekuni
  • Journal Title: Cellular Physiology and Biochemistry Volume: 45 Issue: 6 Pages: 2444-2460
  • DOI: 10.1159/000488263
  • Peer Reviewed / Open Access
• [Journal Article] Mechanistic study of nonivamide enhancement of hyperthermia-induced apoptosis in U937 cells (2018)
  • Author(s): Sun Lu、Cui Zheng-Guo、Zakki Shahbaz Ahmad、Feng Qian-Wen、Li Meng-Ling、Inadera Hidekuni
  • Journal Title: Free Radical Biology and Medicine Volume: 120 Pages: 147-159
  • DOI: 10.1016/j.freeradbiomed.2018.03.017
  • Peer Reviewed
• [Journal Article] Potential hazards of fenvalerate in massive pollution influence the apoptosis sensitivity (2017)
  • Author(s): Cui Zheng-Guo、Jin Yu-Jie、Sun Lu、Zakki Shahbaz Ahmad、Li Meng-Ling、Feng Qian-Wen、Kondo Takashi、Ogawa Ryohei、Inadera Hidekuni
  • Journal Title: Journal of Applied Toxicology Volume: 38 Issue: 2 Pages: 240-247
  • DOI: 10.1002/jat.3517
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Personal perspective on Environmental Health and Preventive Medicine (2017)
  • Author(s): Inadera Hidekuni
  • Journal Title: Environ Health Prev Med Volume: 22 Issue: 1 Pages: 16-16
  • DOI: 10.1186/s12199-017-0647-2
  • NAID: 210000130215
  • Peer Reviewed
• [Journal Article] Association between social capital and the prevalence of gestational diabetes mellitus: An interim report of the Japan Environment and Children's Study (2016)
  • Author(s): Mizuno S, Nishigori H, Sugiyama T, Takahashi F, Iwama N, Watanabe Z, Sakurai K, Ishikuro M, Obara T, Tatsuta N, Nishijima I, Fujiwara I, Arima T, Kuriyama S, Metoki H, Nakai K, Inadera H, Yaegashi N; Japan Environment & Children’s Study Group
  • Journal Title: Diabetes Res Clin Pract Volume: 120 Pages: 132-41
  • DOI: 10.1016/j.diabres.2016.07.020
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Serum n-3 polyunsaturated fatty acids and psychological distress in early pregnancy: adjunct case-control study of the Japan Environment and Children’s Study. (2016)
  • Author(s): Hamazaki K, Harauma A, Otaka Y, Moriguchi T, Inadera H.
  • Journal Title: Transl Psychiatry Volume: 6 Issue: 2 Pages: e737-e737
  • DOI: 10.1038/tp.2016.2
  • Peer Reviewed / Open Access
• [Journal Article] Effect of desert dust exposure on allergic symptoms. Annals of allergy, asthma & immunology: official publication of the American College of Allergy (2016)
  • Author(s): Kumiko T. Kanatani, Kei Hamazaki, Hidekuni Inadera, Nobuo Sugimoto, Atsushi Shimizu, Hisashi Noma, Kazunari Onishi, Yoshimitsu Takahashi,Toshiko Itazawa, Miho Egawa, Keiko Sato, Tohshin Go, Isao Ito, Youichi Kurozawa, Ikuo Konishi, Yuichi Adachi, Takeo Nakayama, for the Japan Environment & Children’s Study Group
  • Journal Title: Asthma, & Immunology Volume: 116(5) Issue: 5 Pages: 425-430
  • DOI: 10.1016/j.anai.2016.02.002
  • Peer Reviewed
• [Journal Article] Insight into the molecular mechanism of heme oxygenase-1 induction by docosahexaenoic acid in U937 cells. (2015)
  • Author(s): Cui ZG, Ogawa R, Tsuneyama K, Yan G, Tao L, Shimomura A, Inadera H.
  • Journal Title: Chem Biol Interact. Volume: 238 Pages: 180-188
  • DOI: 10.1016/j.cbi.2015.07.005
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Effect of preterm birth on growth and cardiovascular disease risk at school age. (2015)
  • Author(s): Inomata S, Yoshida T, Koura U, Tamura K, Hatasaki K, Imamura H, Mase D, KigawaM, Adachi Y, Inadera H.
  • Journal Title: Pediatr Int. Volume: 57 Issue: 6 Pages: 1126-1130
  • DOI: 10.1111/ped.12732
  • NAID: 120006389616
  • Peer Reviewed
• [Journal Article] Neurological effects of bisphenol A and its analogues. (2015)
  • Author(s): Inadera H.
  • Journal Title: Int J Med Sci. Volume: 12 Issue: 12 Pages: 926-936
  • DOI: 10.7150/ijms.13267
  • Open Access
• [Presentation] バイカリンによる温熱誘発アポトーシスの増強とその分子メカニズム (2017)
  • Author(s): 崔正国,Shahbaz Ahmad Zakki,周徳軍,Sun Lu,Qianwen Feng,金玉潔,稲寺秀邦.
  • Organizer: 第87回日本衛生学会学術総会
• [Presentation] ノニバミドによる温熱誘発アポトーシスの増強効果に関する検討 (2017)
  • Author(s): Sun Lu, 崔正国,Shahbaz Ahmad Zakki,Qianwen Feng,稲寺秀邦.
  • Organizer: 第87回日本衛生学会学術総会
• [Presentation] Serum n-3 polyunsaturated fatty acids and psychological distress in the second and third trimesters of pregnancy: Adjunct Study of Japan Environment and Children's Study. (2016)
  • Author(s): Hamazaki K, Harauma A, Moriguchi T, Inadera H.
  • Organizer: 12th Congress of The International Society for the Study of Fatty Acids and Lipids
  • Place of Presentation: Stellenbosch.
  • Year and Date: 2016-09-05
  • Int'l Joint Research
• [Presentation] 低濃度フェンバレレートの曝露によるアポトーシス感受性の変化とその分子メカニズム (2016)
  • Author(s): 崔正国, 金玉潔, Sun Lu, ザッキシャハバズアハマド, 稲寺秀邦.
  • Organizer: 第86回日本衛生学会学術総会
  • Place of Presentation: 旭川
  • Year and Date: 2016-05-11
• [Presentation] Serum n-3 polyunsaturated fatty acids and depression risk in early pregnancy: Adjunct case-control study of the Japan Environment & Children's Study. (2016)
  • Author(s): Hamazaki K, Harauma A, Otaka Y, Moriguchi T, Inadera H.
  • Organizer: American Psychosomatic Society 74th Annual Scientific Meeting
  • Place of Presentation: Denver
  • Year and Date: 2016-05-09
  • Int'l Joint Research
• [Presentation] 大学生における魚食頻度と抑うつとの関連 -横断的研究より- (2015)
  • Author(s): 浜崎景, 城川美佳, 稲寺秀邦
  • Organizer: 第74回日本公衆衛生学総会
  • Place of Presentation: 長崎
  • Year and Date: 2015-11-04
• [Presentation] Role of reactive oxygen species in the carcinogenesis induced by environmental pollutant. (2015)
  • Author(s): Cui ZG, Inadera H.
  • Organizer: 17th International Conference on Oxidative Stress Reduction, Redox Homeostasis and Antioxidants.
  • Place of Presentation: パリ
  • Year and Date: 2015-06-13
  • Int'l Joint Research