Molecular nutritional study for prevention of prostate cancer

• Project/Area Number: 15K08779
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Hygiene and public health
• Research Institution: Kumamoto University
• Principal Investigator: Katoh Takahiko 熊本大学, 大学院生命科学研究部(医), 教授 (70169506)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 前立腺がん / 栄養 / 食物摂取頻度調査票 / 分子疫学 / ヘテロサイクリックアミン / 遺伝子多型 / 食物摂取頻度調査

Outline of Final Research Achievements

We conducted a comprehensive molecular nutrition epidemiological analysis to clarify the risk factors for prostate cancer in Japanese population. These finding indicate that high heterocyclic aromatic amines intake is a risk factors of prostate cancer in Japanese men, and that the genotypes of N-acetyltransferase 2, Cytochrome P450CYP1A1, and Cytochrome P4501A2 may affect the degree of cancer risk via changes in heterocyclic aromatic amines -metabolizing enzymes.

Research Products

• [Journal Article] Association between NAT2, CYP1A1, and CYP1A2 genotypes, heterocyclic aromatic amines, and prostate cancer risk: a case control study in Japan. (2017)
  • Author(s): Koda M., Iwasaki M, Yamano Y, Lu X, Katoh T.
  • Journal Title: Environ Health Prev Med Volume: 22 Issue: 1 Pages: 22-81
  • DOI: 10.1186/s12199-017-0681-0
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Associations between estrogen receptor genetic polymorphisms, smoking status, and prostate cancer risk: a case-control study in Japanese men (2015)
  • Author(s): Lu X1, Yamano Y, Takahashi H, Koda M, Fujiwara Y, Hisada A, Miyazaki W, Katoh T.
  • Journal Title: Environ Health Prev Med. Volume: 20 Issue: 5 Pages: 332-337
  • DOI: 10.1007/s12199-015-0471-5
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] 環境・人の多様性と健康障害 (2017)
  • Author(s): 加藤貴彦
  • Organizer: 日本衛生学会
  • Place of Presentation: 宮崎県宮崎市
  • Year and Date: 2017-03-26
  • Invited
• [Presentation] ヘテロサイクリックアミン曝露と前立腺がん発症リスクに関する分子疫学研究 (2017)
  • Author(s): 香田将英、盧渓、加藤貴彦
  • Organizer: 第76回日本公衆衛生学会総会
• [Presentation] 遺伝子検査の現状と課題（シンポジウム） (2016)
  • Author(s): 加藤貴彦
  • Organizer: 第89回日本産業衛生学会
  • Place of Presentation: 福島県福島市
  • Year and Date: 2016-05-24