| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
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| Outline of Final Research Achievements |
We conducted two independent case-control studies, the first for model derivation (697 cases and 1,372 controls) and the second (678 and 678) for external validation. Using the derivation study data, we developed a prediction model by fitting a conditional logistic regression model using the following predictors: age, ABC classification defined by H.pylori infection and atrophic gastritis, smoking, fruit and vegetable intake, and selected GWAS-identified polymorphisms. Performance was assessed regarding discrimination (area under the curve, AUC).
A combination of four GWAS-identified polymorphisms and the other predictors provided high discriminatory accuracy in both studies, with AUCs of 0.79 (95% confidence intervals, 0.77-0.81) and 0.80 (0.77-0.82), respectively. This risk prediction model, which includes genetic, biological and lifestyle-related factors, might be useful in classifying Japanese into relevant risk groups of gastric cancer for personalized prevention programs.
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