| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Outline of Final Research Achievements |
We have examined the effect of sympathetic hyperactivity on sex hormone secretion in order to elucidate the neurogenic mechanism of sex hormone secretion abnormality caused by stress. The present study aimed to clarify, whether hypothalamus is essential for this physical stress-induced inhibition of ovarian estradiol secretion, by using decerebrate animals. In central nervous system-intact rats, electrical stimulation of a tibial afferent nerve at supra-maximal intensity for C-fibers increased the efferent activity of SON by 39%, and decreased the estradiol secretion rate from the ovary by 34%. These responses were observed in decerebrate rats, but were abolished in spinal rats. In conclusion, the present study demonstrated that the main integration center for decrease response of ovarian estradiol secretion due to SON activation produced by physical stress (tibial nerve stimulation) is located in the brain stem in anesthetized rats.
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