Establishment of a novel therapeutic strategy for heart failure based on an understanding of metabolic regulation
| Project/Area Number |
15K09081
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cardiovascular medicine
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| Research Institution | Kobe University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
杜 隆嗣 神戸大学, 医学研究科, 特命准教授 (50379418)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 心不全 / メタボローム解析 / βヒドロキシ酪酸 / 2-アミノ酪酸 / グルタチオン / 糖尿病 / 肥満 / 左室拡張能 / 心エコー図 / 抗がん剤 |
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| Outline of Final Research Achievements |
1) A comprehensive quantification of serum metabolites in patients with atrial septal defect revealed that circulating levels of β-hydroxybutyrate (βOHB) and 2-aminobutyric acid (2-AB) reflected hemodynamic changes. We found that βOHB exert cardioprotective effects against oxidative stress. We also revealed that 2-AB modulates glutathione homeostasis. 2) Coexistence of left ventricular (LV) longitudinal myocardial systolic dysfunction with LV diastolic dysfunction could lead to heart failure with preserved ejection fraction (HFpEF). Diabetes mellitus (DM) is known as a significant factor associated with HFpEF. We revealed the impact of overweight on LV longitudinal myocardial systolic function in patients with type II DM.
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Report
(4 results)
Research Products
(12 results)
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[Journal Article] 2-Aminobutyric acid modulates glutathione homeostasis in the myocardium.2016
Author(s)
Irino Y, Toh R, Nagao M, Mori T, Honjo T, Shinohara M, Tsuda S, Nakajima H, Satomi-Kobayashi S, Shinke T, Tanaka H, Ishida T, Miyata O, Hirata KI.
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Journal Title
Sci Rep.
Volume: -
Issue: 1
Pages: 36749-36749
DOI
NAID
Related Report
Peer Reviewed / Open Access
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[Journal Article] Clinical features of subclinical left ventricular systolic dysfunction in patients with diabetes mellitus.2015
Author(s)
Mochizuki Y, Tanaka H, Matsumoto K, Sano H, Toki H, Shimoura H, Ooka J, Sawa T, Motoji Y, Ryo K, Hirota Y, Ogawa W, Hirata K.
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Journal Title
Cardiovasc Diabetol.
Volume: 14
Issue: 1
Pages: 37-37
DOI
NAID
Related Report
Peer Reviewed
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[Journal Article] Association of peripheral nerve conduction in diabetic neuropathy with subclinical left ventricular systolic dysfunction.2015
Author(s)
Mochizuki Y, Tanaka H, Matsumoto K, Sano H, Toki H, Shimoura H, Ooka J, Sawa T, Motoji Y, Ryo K, Hirota Y, Ogawa W, Hirata K.
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Journal Title
Cardiovasc Diabetol.
Volume: 14
Issue: 1
Pages: 47-47
DOI
NAID
Related Report
Peer Reviewed
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