Relationship between FGF23/a-Klotho axis and Cardiac Remodeling in Patients with Cardiomyopathy.

• Project/Area Number: 15K09106
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Cardiovascular medicine
• Research Institution: Osaka Medical College
• Principal Investigator: MORITA Hideaki 大阪医科大学, 医学部, 講師 (80445981)
• Co-Investigator(Kenkyū-buntansha): 石坂 信和 大阪医科大学, 医学部, 教授 (20270879) ; 星賀 正明 大阪医科大学, 医学部, 教授 (90309154) ; 伊藤 隆英 大阪医科大学, 医学部, 講師 (00319550) ; 藤田 修一 大阪医科大学, 医学部, 講師 (80722628)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2017: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: FGF23 / α-Klotho / 急性心筋梗塞 / 心筋症 / 心不全 / 心臓リモデリング

Outline of Final Research Achievements

Serum FGF23 and α- Klotho were measured in 885 patients who admitted to cardiovascular department. FGF23 was significantly elevated in 49 cases of cardiomyopathy. There was no significant increase in serum FGF23 in specific cardiomyopathy and it seemed that there was no difference in FGF23 elevation depending on the type of cardiomyopathy. In patients with acute myocardial infarction, it was found that the FGF23 decreased significantly at the 1-3 th day compared to the time of admission and significantly increased at the 5-7 th day. A significant negative correlation was found between the rate of increase in FGF23 in the acute phase of myocardial infarction and the left ventricular ejection fraction in the chronic phase, suggesting that FGF23 may be a predictor of cardiac remodeling. We hope that the FGF/α-Klotho system will become a therapeutic target for prevention of cardiac remodeling in the future.

Research Products

• [Journal Article] Changes in Serum Fibroblast Growth Factor 23 in Patients With Acute Myocardial Infarction (2018)
  • Author(s): Takahashi H, Ozeki M, Fujisaka T, Morita H, Fujita SI, Takeda Y, Shibata K, Sohmiya K, Hoshiga M, Tamaki J, Ishizaka N.
  • Journal Title: Circulation Journal Volume: 82 Issue: 3 Pages: 767-774
  • DOI: 10.1253/circj.CJ-17-0826
  • NAID: 130006394497
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed / Open Access
• [Journal Article] Serum inorganic phosphate level is associated with fibroblast growth factor 23 among cardiac patients with preserved renal function. (2017)
  • Author(s): Morita H, Fujisaka T, Fujita SI, Ishizaka N.
  • Journal Title: Hypertens Res. Volume: 40(7) Issue: 7 Pages: 717-9
  • DOI: 10.1038/hr.2017.20
  • Peer Reviewed / Open Access
• [Journal Article] Association between suPAR and cardiac diastolic dysfunction among patients with preserved ejection fraction. (2017)
  • Author(s): Fujisaka T, Fujita SI, Maeda D, Shibata K, Takahashi H, Morita H, Takeda Y, Ito T, Sohmiya K, Hoshiga M, Ishizaka N.
  • Journal Title: Heart Vessels. Volume: 32(11) Issue: 11 Pages: 1327-36
  • DOI: 10.1007/s00380-017-1002-7
  • Peer Reviewed / Open Access
• [Journal Article] Association between serum soluble urokinase-type plasminogen activator receptor and atrial fibrillation. (2017)
  • Author(s): Ichihara N, Miyamura M, Maeda D, Fujisaka T, Fujita SI, Morita H, Takeda Y, Ito T, Sohmiya K, Hoshiga M, Ishizaka N.
  • Journal Title: J Arrhythm. Volume: 33(5) Issue: 5 Pages: 469-74
  • DOI: 10.1016/j.joa.2017.05.003
  • Peer Reviewed / Open Access
• [Journal Article] 解説～CVDと高尿酸血症 (2017)
  • Author(s): 森田英晃、石坂信和
  • Journal Title: CLINIC magazine Volume: 580 Pages: 15-9
• [Journal Article] Association between FGF23, α-Klotho, and Cardiac Abnormalities among Patients with Various Chronic Kidney Disease Stages. (2016)
  • Author(s): Tanaka S, Fujita S, Kizawa S, Morita H, Ishizaka N.
  • Journal Title: PLoS One. Volume: 11(7) Issue: 7 Pages: e0156860-e0156860
  • DOI: 10.1371/journal.pone.0156860
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Association between circulating FGF23, α-Klotho, and left ventricular diastolic dysfunction among patients with preserved ejection fraction. (2016)
  • Author(s): Okamoto Y, Fujita S, Morita H, Kizawa S, Ito T, Sakane K, Sohmiya K, Hoshiga M, Ishizaka N.
  • Journal Title: Heart Vessels. Volume: 1(1) Issue: 1 Pages: 66-73
  • DOI: 10.1007/s00380-014-0581-9
  • Peer Reviewed
• [Journal Article] Gender Specific Association between Serum Fibroblast Growth Factor 23/α-Klotho and Coronary Artery and Aortic Valve Calcification (2015)
  • Author(s): Morita H, Takeda Y, Fujita S, Okamoto Y, Sakane K, Teramoto K, Ozeki M, Tasaki R, Kizawa S, Sohmiya K, Hoshiga M, Ishizaka N.
  • Journal Title: Journal of Atherosclerosis and Thrombosis Volume: 22 Issue: 12 Pages: 1338-1346
  • DOI: 10.5551/jat.30635
  • NAID: 130005112366
  • ISSN: 1340-3478, 1880-3873
  • Peer Reviewed / Open Access
• [Journal Article] Circulating Fibroblast Growth Factor 23 Has a U-Shaped Association With Atrial Fibrillation Prevalence (2015)
  • Author(s): Miyamura M, Fujita S, Morita H, Sakane K, Okamoto Y, Sohmiya K, Hoshiga M, Ishizaka N.
  • Journal Title: Circulation Journal Volume: 79 Issue: 8 Pages: 1742-1748
  • DOI: 10.1253/circj.CJ-15-0413
  • NAID: 130005089363
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed / Open Access
• [Presentation] 利尿剤は可溶性ウロキナーゼ型プラスミノーゲン活性化因子受容体と心房細動との関係に影響を及ぼす (2017)
  • Author(s): 宮村昌利、伊藤隆英、藤田修一、森田英晃、武田義弘、宗宮浩一、星賀正明、石坂信和
  • Organizer: 第65回日本心臓病学会学術集会
• [Presentation] アルブミン/グロブリン比低値は大動脈壁プラークのリスクファクターである～320列冠動脈CTでの検討 (2017)
  • Author(s): 森田英晃、武田義弘、大関道薫、藤田修一、藤阪智弘、宗宮浩一、星賀正明、石坂信和
  • Organizer: 第65回日本心臓病学会学術集会
• [Presentation] 血中可溶性ウロキナーゼ型プラスミノゲンアクチベータ受容体は心不全増悪による再入院の予測因子である (2017)
  • Author(s): 前田大智、坂根和志、大関道薫、藤田修一、藤阪智弘、武田義弘、森田英晃、伊藤隆英、宗宮浩一、星賀正明、石坂信和
  • Organizer: 第124回日本循環器学会近畿地方会
• [Presentation] Serum Soluble Urokinase-type Plasminogen Activator Receptor is Associated With the Prevalence of Atrial Fibrillation (2017)
  • Author(s): Masatoshi Miyamura, Noboru Ichihara, Yohei Yamauchi, Yuki Fujimura, Daichi Maeda, Tomohiro Fujisaka, Shu-ichi Fujita, Hideaki Morita, Yoshihiro Takeda, Takahide Ito, Koichi Sohmiya, Masaaki Hoshiga and Nobukazu Ishizaka
  • Organizer: AHA2017
  • Int'l Joint Research
• [Presentation] Serum FGF23 Level is Associated With Cardiac Abnormality Among Patients Without Chronic Kidney Disease Stages. (2016)
  • Author(s): Suguru Tanaka, Hideaki Morita, Yoshihiro Takeda, Shu-ichi Fujita, Koichi Sohmiya, Masaaki Hoshiga and Nobukazu Ishizaka.
  • Organizer: AHA2016
  • Place of Presentation: アメリカ ニューオーリンズ
  • Year and Date: 2016-11-13
  • Int'l Joint Research
• [Presentation] AMI症例のPCI後の血清FGF23値の推移 (2016)
  • Author(s): 高橋秀明、森田英晃、武田義弘、宗宮浩一、星賀正明、石坂信和
  • Organizer: 第64回日本心臓病学会学術集会
  • Place of Presentation: 東京国際フォーラム
  • Year and Date: 2016-09-23
• [Presentation] 慢性腎臓病を認めない症例においてもFGF23高値は心肥大のリスクである (2016)
  • Author(s): 藤田修一、森田英晃、宗宮浩一、星賀正明、石坂信和
  • Organizer: 第64回日本心臓病学会学術集会
  • Place of Presentation: 東京国際フォーラム
  • Year and Date: 2016-09-23
• [Presentation] 心筋症患者において血清FGF２３値は増加しているか？ (2016)
  • Author(s): 藤田修一、寺﨑文生、森田英晃、石坂信和
  • Organizer: 第2回日本心筋症研究会
  • Place of Presentation: まつもと市民芸術館（長野県松本市）
  • Year and Date: 2016-05-14
• [Presentation] 心筋症患者において血清FGF23値は増加しているか？ (2016)
  • Author(s): 藤田修一，寺﨑文生，森田英晃，石坂信和
  • Organizer: 第2回日本心筋症研究会
  • Place of Presentation: まつもと市民芸術館
• [Presentation] Serum FGF23 and α-Klotho concentrations are associated with basal renal function、 but not with change in renal function following coronary artery angiography (2015)
  • Author(s): Shu-ichi Fujita、 Hideaki Morita、 Yusuke Okamoto、 Yoshihiro Takeda、 Koichi Sohmiya、 Masaaki Hoshiga、 Nobukazu Ishizaka
  • Organizer: AHA Scientific Sessions 2015
  • Place of Presentation: アメリカ・オーランド
  • Year and Date: 2015-11-07
  • Int'l Joint Research
• [Presentation] Serum FGF23 is Increased and α-Klotho is Decreased in Patients with Enhanced Coronary Calcification―Analysis of Computed CT Images (2015)
  • Author(s): Hideaki Morita , Yoshihiro Takeda , Shuichi Fujita , Jun Tanigawa , Shuji Suzuki , Koichi Sohmiya , Masaaki Hoshiga , Nobukazu Ishizaka
  • Organizer: 第79回日本循環器学会学術集会
  • Place of Presentation: 大阪国際会議場（大阪市）
  • Year and Date: 2015-04-24
• [Presentation] Patients with Atrial Fibrillation Have Higher Serum FGF23 Levels Independent of Serum Calcium/Phosphate and Renal Function (2015)
  • Author(s): Masatoshi Miyamura , Shuichi Fujita , Yuusuke Okamoto , Yoshihiro Takeda , Hideaki Morita , Koichi Sohmiya , Masaaki Hoshiga , Nobukazu Ishizaka
  • Organizer: 第79回日本循環器学会学術集会
  • Place of Presentation: 大阪国際会議場（大阪市）
  • Year and Date: 2015-04-24