Hemodynamic approach for the evaluation of patients with ischemic heart disease
Project/Area Number |
15K09120
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Cardiovascular medicine
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Research Institution | Kobe University |
Principal Investigator |
Otake Hiromasa 神戸大学, 医学部附属病院, 講師 (60593803)
|
Co-Investigator(Kenkyū-buntansha) |
新家 俊郎 神戸大学, 医学部附属病院, 准教授 (60379419)
|
Project Period (FY) |
2015-04-01 – 2018-03-31
|
Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
|
Keywords | ずり応力 / 血行力学的因子 / プラークの不安定化 / Shear stress / thin cap fibroatheroma / computed tomography / OCT |
Outline of Final Research Achievements |
We showed that unstable, rupture prone plaque is related with several hemodynamic parameters such as wall shear stress and axial plaque stress. Also, we showed that, in patients treated with coronary stents, vessel healing is affected not only by wall shear stress, but by wall shear stress exposed time and wall shear stress variability. These findings suggest that using computational fluid dynamics analysis might help patients with coronary artery disease to prevent acute coronary event as well as stent related events such as restenosis and stent thrombosis.
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Report
(4 results)
Research Products
(15 results)
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[Journal Article] Lumen Boundaries Extracted from Coronary Computed Tomography Angiography on Computed Fractional Flow Reserve (FFRCT): Validation with Optical Coherence Tomography.2018
Author(s)
Kenzo Uzu, Hiromasa Otake, Gilwoo Choi, Takayoshi Toba, Hyun Jin Kim, Arjun Roy, Michiel Schaap, Leo Grady, Masahito Kawata, Toshiro Shinke, Charles A. Taylor, Ken-ichi Hirata
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Journal Title
EuroIntervention
Volume: 印刷中
Issue: 15
Pages: e1609-e1618
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Computational fluid dynamic measures of wall shear stress are related to coronary lesion characteristics2016
Author(s)
Park JB, Choi G, Chun EJ, Kim HJ, Park J, Jung JH, Lee MH, Otake H, Doh JH, Nam CW, Shin ES, De Bruyne B, Taylor CA, Koo BK.
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Journal Title
Heart
Volume: 102(20)
Issue: 20
Pages: 1655-1661
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Coronary Artery Axial Plaque Stress and its Relationship With Lesion Geometry: Application of Computational Fluid Dynamics to Coronary CT Angiography.2015
Author(s)
Choi G, Lee JM, Kim HJ, Park JB, Sankaran S, Otake H, Doh JH, Nam CW, Shin ES, Taylor CA, Koo BK.
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Journal Title
journal of american college of cardiology cardiovascular imaging
Volume: 印刷中
Issue: 10
Pages: 1156-1166
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Presentation] Why does thin-cap fibroatheroma cluster in the proximal segment in left anterior coronary artery, but are evenly distributed throughout the entire right coronary artery? ;Results from computational fluid dynamics simulation by CT-FFR-2017
Author(s)
鳥羽 敬義, Gilwoo Choi,Hyun Jin Kim, Arjun Roy, Tran Nguyen, Michiel Schaa, Leo Grady, 宇津 賢三, 森 俊平, 新家 俊郎, Bon-Kwon Koo, Charles Taylor, 大竹 寛雅
Organizer
第81回日本循環器学会学術集会金沢
Related Report
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[Presentation] Impact of precision of lumen boundary extracted from coronary CT on FFRCT: validation with OCT2016
Author(s)
Takayoshi Toba, Gilwoo Choi, Kenzo Uzu, Hyun Jin Kim, Arjun Roy, Tran Nguyen, Michiel Schaap, Leo Grady, Shumpei Mori, Tomofumi Takaya, Toshiro Shinke, Bon-Kwon Koo, Charles Taylor, Hiromasa Otake
Organizer
American college of cardiology 2016
Place of Presentation
Chicago, USA
Year and Date
2016-04-02
Related Report
Int'l Joint Research
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[Presentation] Evaluation of local hemodynamic forces acting on plaque may help predict plaque vulnerability; Lessons from combined analysis of optical coherence tomography and computational fluid dynamics simulation2016
Author(s)
Kenzo Uzu, Gilwoo Choi,, Hyun Jin Kim, Arjun Roy, Tran Nguyen, Michiel Schaap, Leo Grady, Takayoshi Toba, Shumpei Mori, Tomofumi Takaya, Toshiro Shinke, Bon-Kwon Koo, Charles Taylor, Hiromasa Otake
Organizer
American college of cardiology 2016
Place of Presentation
Chicago, USA
Year and Date
2016-04-02
Related Report
Int'l Joint Research
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[Presentation] Impact of Wall Shear Stress and Axial Plaque Stress on Coronary Plaque Initiation and Progression2016
Author(s)
Takayoshi Toba, Gilwoo Choi, Hyun Jin Kim, Arjun Roy, Tran Nguyen, Michiel Schaap, Leo Grady, Kenzo Uzu, Shumpei Mori, Tomofumi Takaya, Toshiro Shinke, Bon-Kwon Koo, Charles Taylor, Hiromasa Otake
Organizer
American college of cardiology 2016
Place of Presentation
Chicago, USA
Year and Date
2016-04-02
Related Report
Int'l Joint Research
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[Presentation] Correlation of Wall Shear Stress and Axial Plaque Stress between models derived from CT and OCT data2016
Author(s)
Gilwoo Choi, Kenzo Uzu, Takayoshi Toba, Hyun Jin Kim, Arjun Roy, Tran Nguyen, Bon-Kwon Koo, Leo Grady, Charles Taylor, Hiromasa Otake
Organizer
American college of cardiology 2016
Place of Presentation
Chicago, USA
Year and Date
2016-04-02
Related Report
Int'l Joint Research