Pulmonary collectin regulates the severity of Streptococcus pneumoniae infection

• Project/Area Number: 15K09181
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Respiratory organ internal medicine
• Research Institution: Sapporo Medical University
• Principal Investigator: Kuronuma Koji 札幌医科大学, 医学部, 講師 (40563250)
• Co-Investigator(Kenkyū-buntansha): 高橋 弘毅 札幌医科大学, 医学部, 教授 (60231396)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 肺コレクチン / 肺炎球菌 / 感染症 / 肺炎球菌感染症

Outline of Final Research Achievements

Pneumococcal infections tend to be severe, especially invasive pneumococcal infections also have a high mortality rate. Differences in the severity of pneumococcal infection caused by capsular serotypes have been reported by epidemiological studies. Our surveillance in Hokkaido has also revealed the serotype replacement of invasive pneumococcal infections which is related to the spread of pneumococcal vaccines. We confirmed that lung collectin specifically binds to pneumococcal components and activates macrophages and increases antibiotic activity by increasing the receptors necessary for phagocytosis of bacteria. It became clear that the relation with the regulatory factors such as vaccine effect, host immune status and pulmonary collectin is important as a pathological condition of pneumococcus.

Research Products

• [Journal Article] Impaired diversity of the lung microbiome predicts progression of idiopathic pulmonary fibrosis (2018)
  • Author(s): Takahashi Youhei、Saito Atsushi、Chiba Hirofumi、Kuronuma Koji、Ikeda Kimiyuki、Kobayashi Tomofumi、Ariki Shigeru、Takahashi Motoko、Sasaki Yasushi、Takahashi Hiroki
  • Journal Title: Respir Res Volume: 19 Issue: 1 Pages: 34-34
  • DOI: 10.1186/s12931-018-0736-9
  • Peer Reviewed / Open Access
• [Journal Article] Whole genome analysis of a multidrug-resistant Streptococcus pneumoniae isolate from a patient with invasive pneumococcal infection developing disseminated intravascular coagulation (2018)
  • Author(s): Ohkoshi Yasuo、Sato Toyotaka、Wada Takayuki、Fukushima Yukari、Murabayashi Hiromi、Takakuwa Yasunari、Nishiyama Kaoru、Honda Hiroyuki、Shiraishi Tsukasa、Kuronuma Koji、Takahashi Hiroki、Nakajima Chie、Suzuki Yasuhiko、Yokota Shin-ichi
  • Journal Title: J Infect Chemother Volume: 印刷中 Issue: 8 Pages: 674-681
  • DOI: 10.1016/j.jiac.2018.01.012
  • Peer Reviewed / Open Access
• [Journal Article] Surfactant Protein A (SP-A) and SP-A-derived Peptide Attenuate Chemotaxis of Mast Cells Induced by Human β-defensin 3. (2017)
  • Author(s): Uehara Y., Takahashi M., Murata M., Saito A., Takamiya R., Hasegawa Y., Kuronuma K., Chiba H., Hashimoto J., Sawada N., Takahashi H., Kuroki Y., Ariki S.
  • Journal Title: Biochem. Biophys. Res. Commun. Volume: 485 Issue: 1 Pages: 107-112
  • DOI: 10.1016/j.bbrc.2017.02.028
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Presentation] Pneumococcal vaccination in interstitial lung disease patients receiving systemic immunosuppressive treatment. (2017)
  • Author(s): Koji Kuronuma, Hiroyuki Honda, Tessei Mikami, Yuichiro Asai, Youhei Takahashi, Tomofumi Kobayashi, Atsushi Saito, Kimiyuki Ikeda, Hirotaka Nishikiori, Mamoru Takahashi, Mitsuo Otsuka, Hirofumi Chiba, Gen Yamada, Hiroki Takahashi, Toyotaka Sato
  • Organizer: 27th European Respiratory Society Annual Congress 2017.
  • Int'l Joint Research
• [Presentation] Retrospective analysis of microbiome in idiopathic pulmonary fibrosis. (2017)
  • Author(s): Youhei Takahashi, Astushi Saito, Kimiyuki Ikeda, Koji Kuronuma, Tomofumi Kobayashi, Yuichiro Asai, Hirotaka Nishikiori, Gen Yamada, Hirofumi Chiba, Yasushi Sasaki, Hiroki Takahashi, Mitsuo Otsuka, Mamoru Takahashi
  • Organizer: 27th European Respiratory Society Annual Congress 2017.
  • Int'l Joint Research
• [Presentation] 北海道における侵襲性肺炎球菌感染症症例の検討 (2015)
  • Author(s): 黒沼幸治
  • Organizer: 第55回日本呼吸器学会学術講演会
  • Place of Presentation: 東京国際フォーラム（東京都千代田区）
  • Year and Date: 2015-04-17
• [Presentation] 北海道における侵襲性細菌感染症サーベイランス構築の取組 (2015)
  • Author(s): 黒沼幸治
  • Organizer: 第112回日本内科学会講演会
  • Place of Presentation: みやこめっせ（京都市左京区）
  • Year and Date: 2015-04-10