| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Outline of Final Research Achievements |
Pneumococcal infections tend to be severe, especially invasive pneumococcal infections also have a high mortality rate. Differences in the severity of pneumococcal infection caused by capsular serotypes have been reported by epidemiological studies. Our surveillance in Hokkaido has also revealed the serotype replacement of invasive pneumococcal infections which is related to the spread of pneumococcal vaccines. We confirmed that lung collectin specifically binds to pneumococcal components and activates macrophages and increases antibiotic activity by increasing the receptors necessary for phagocytosis of bacteria. It became clear that the relation with the regulatory factors such as vaccine effect, host immune status and pulmonary collectin is important as a pathological condition of pneumococcus.
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