Roles of TNF-like weak inducer of apoptosis/fibroblast growth factor-inducible 14 signaling in lung epithelial cells during lung regeneration

• Project/Area Number: 15K09217
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Respiratory organ internal medicine
• Research Institution: Kyoto University
• Principal Investigator: Sato Atsuyasu 京都大学, 医学研究科, 助教 (30706677)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2015: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: Tweak / Fn14 / 肺傷害 / 再生 / クラブ細胞

Outline of Final Research Achievements

TNF-like weak inducer of apoptosis and fibroblast growth factor-inducible 14 are recognized as a fundamental factors for cell proliferation. In the present study, we hypothesized that those signaling is critical for lung epithelial regeneration. In acute lung injury model, lacking of those signaling promoted prolonged repair time course, but finally showing good regeneration after lung injury,suggesting a partial important role in the early phase of regeneration, but alternative compensation might be involved in the mechanism.