| Project/Area Number |
15K09220
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Osaka University |
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Principal Investigator |
Kijima Takashi 大阪大学, 医学系研究科, 招へい教授 (90372614)
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| Co-Investigator(Kenkyū-buntansha) |
南 俊行 大阪大学, 医学系研究科, 特任助教(常勤) (00705113)
小山 正平 大阪大学, 免疫学フロンティア研究センター, 特任助教(常勤) (80767559)
長 彰翁 大阪大学, 医学部附属病院, 医員 (20751390)
森村 治 大阪大学, 医学部附属病院, 医員 (80743765)
内藤 祐二朗 大阪大学, 医学部附属病院, 医員 (30800982)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 肺癌 / 癌微小環境 / 内在性リガンド / アポトーシス小体 / 無菌的炎症誘導 / 化学療法抵抗性 / Toll様受容体 / 微小環境 / 無菌的炎症 / 腫瘍関連マクロファージ / 腫瘍関連線維芽細胞 / MyD88 / 内在性リガント |
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| Outline of Final Research Achievements |
In this study, we evaluated how tumor-associated vesicles like apoptotic bodies released after chemotherapies can modulate tumor microenvironment in terms of sensitivity to subsequent chemotherapies. We found that a specific type of chemotherapy can induce TLR2 ligand, which modulate inflammatory status in lung cancer microenvironment and reduce the sensitivity for the subsequent chemotherapies.
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