| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
Chronic inflammation contributes to the progression of kidney disease. We found the novel macrophage regulator molecule, which is involved in progressive kidney injury in mice model. Moreover, Apoptosis inhibitor of macrophage (AIM), which is secreted by macrophage, was detected in various kinds of human kidney disease in kidney biopsy specimen. The deposition of AIM was associated with the increase of proteinuria and the decline of eGFR. These results showed the important role of macrophage in progressive kidney disease both in mouse and human.
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