Measurement of neural connectivity at rest and during tasks by magnetoencephalography system

• Project/Area Number: 15K09349
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Neurology
• Research Institution: Nagoya University
• Principal Investigator: Hoshiyama Minoru 名古屋大学, 脳とこころの研究センター, 教授 (30270482)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2017: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 脳磁図 / 誘発脳反応 / 皮質内接続 / 安静時脳活動 / 脳内神経接続 / 脳磁計 / 核磁気共鳴画像 / 脳内ネットワーク / 運動イメージ / 視覚誘発脳反応 / 脳磁場 / connectivity

Outline of Final Research Achievements

Resting and task-related magnetic cortical fields were measured by a magnetoencephalographic system (MEG), and inter-cortical connectivity was analyzed in physiological and pathological conditions. Change in neural connectivity during somatosensory, auditory, and motor tasks were calculated using latest methods, dipole distribution and coherence/correlation analyses, in healthy subjects. Pathological neural connectivity was investigated in patients with peripheral neuropathy, such as median nerve neuropathy at the wrist, and in patients with central nervous system. Parkinson’s disease. Present series of study resulted in 11 papers published in international journals. We believe that methods for analyzing inter-cortical connectivity during tasks and at rest have been established during our studies. Our methods could be applied to analysis using clinical electroencephalography recording. Application to clinical examination might be possible.

Research Products

• [Journal Article] Brain Activity on Observation of Another Person’s Action: A Magnetoencephalographic Study (2018)
  • Author(s): Mizuno Jumpei、Kawamura Masashi、Hoshiyama Minoru
  • Journal Title: Motor Control Volume: 28 Issue: 4 Pages: 1-14
  • DOI: 10.1123/mc.2017-0053
  • Peer Reviewed
• [Journal Article] Feed-forward-related neural activity for vocalization: A pilot study using magnetoencephalography (2018)
  • Author(s): Kawamura Masashi、Mizuno Jumpei、Hoshiyama Minoru
  • Journal Title: Neurology, Psychiatry and Brain Research Volume: 27 Pages: 21-26
  • Peer Reviewed
• [Journal Article] An unbiased data-driven age-related structural brain parcellation for the identification of intrinsic brain volume changes over the adult lifespan. (2018)
  • Author(s): Bagarinao E
  • Journal Title: Neuroimage. Volume: 169 Pages: 134-144
  • DOI: 10.1016/j.neuroimage.2017.12.014
  • Peer Reviewed / Open Access
• [Journal Article] Detecting sub-second changes in brain activation patterns during interictal epileptic spike using simultaneous EEG-fMRI (2017)
  • Author(s): Epifanio Bagarinao, Satoshi Maesawa, Yuji Ito, Naotaka Usui, Jun Natsume, Hirohisa Watanabe, Minoru Hoshiyama, Toshihiko Wakabayashi, Gen Sobue, Shinji Naganawa, Haruo Isoda
  • Journal Title: Clin Neurophysiol. Volume: 129(2) Issue: 2 Pages: 377-389
  • DOI: 10.1016/j.clinph.2017.11.018
  • Peer Reviewed / Open Access
• [Journal Article] Association between changes in visual evoked magnetic fields and non-motor features in Parkinson's disease. (2017)
  • Author(s): Fujisawa Y, Minato T, Uemura JI, Hoshiyama M, Watanabe H, Hirayama M.
  • Journal Title: Nagoya Journal of Medical Science Volume: 79 Pages: 147-155
  • NAID: 120006220102
  • Peer Reviewed
• [Journal Article] Functional inter-cortical connectivity among motor-related cortices during motor imagery: A magnetoencephalographic study. (2017)
  • Author(s): Obayashi Y, Uemura JI, Hoshiyama M.
  • Journal Title: Somatosens Motor Research Volume: 34 Pages: 1-8
  • Peer Reviewed
• [Journal Article] Biomechanical Reconstruction Using the Tacit Learning System: Intuitive Control of Prosthetic Hand Rotation. (2017)
  • Author(s): Oyama S, Shimoda S, Alnajjar FS, Iwatsuki K, Hoshiyama M, Tanaka H, Hirata H.
  • Journal Title: Front Neurorobot Volume: 29 Pages: 19-19
  • Peer Reviewed
• [Journal Article] Functional inter-cortical connectivity among motor-related cortices during motor imagery: A magnetoencephalographic study. (2017)
  • Author(s): Obayashi Y, Uemura JI, Hoshiyama M.
  • Journal Title: Somatosens Mot Res Volume: 34 Issue: 1 Pages: 1-8
  • DOI: 10.1080/08990220.2016.1257985
  • Peer Reviewed
• [Journal Article] Recovery function of somatosensory evoked brain response in patients with carpal tunnel syndrome: A magnetoencephalographic study. (2016)
  • Author(s): Iwatsuki K, Yoshida A, Shinohara T, Nakano T, Uemura J, Goto S, Hirayama M, Hoshiyama M, Hirata H.
  • Journal Title: Clin Neurophysiol Volume: 127 Pages: 2733-2738
  • DOI: 10.1016/j.mito.2016.08.011
  • Peer Reviewed
• [Journal Article] Influence of observing another person's action on self-generated performance in schizophrenia. (2015)
  • Author(s): Nakagawa Y, Hoshiyama M.
  • Journal Title: Cognitive Neuropsychiatry Volume: 20 Issue: 4 Pages: 349-349
  • DOI: 10.1080/13546805.2015.1044081
  • Peer Reviewed
• [Journal Article] Disinhibitory shift of recovery curve of somatosensory-evoked response in elderly: A magnetoencephalographic study (2014)
  • Author(s): Goto, S. Fujisawa, Y. Uemura, J. I. Yamada, S. Hoshiyama, M. Hirayama, M
  • Journal Title: Clin Neurophysiol Volume: 126 Issue: 6 Pages: 1228-33
  • DOI: 10.1016/j.clinph.2014.09.018
  • Peer Reviewed / Open Access / Acknowledgement Compliant