Significance of homeodynamic regulation by hypothalamic orexin in preventing obesity and type 2 diabetes
| Project/Area Number |
15K09380
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Metabolomics
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| Research Institution | University of Toyama |
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Principal Investigator |
TSUNEKI Hiroshi 富山大学, 大学院医学薬学研究部(薬学), 准教授 (20332661)
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| Co-Investigator(Kenkyū-buntansha) |
笹岡 利安 富山大学, 大学院医学薬学研究部(薬学), 教授 (00272906)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 糖尿病 / エネルギー・糖質代謝異常 / 生物時計 / インスリン抵抗性 / エネルギー・糖脂質代謝異常 / 脳・神経 / 生体リズム / オレキシン / 睡眠 |
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| Outline of Final Research Achievements |
Brain plays a major role in maintenance of energy homeostasis by coordinating daily rhythms in biological clock, sleep/wake, and metabolism. To reveal the mechanism, the present study investigated the functional significance of hypothalamic orexin system. In obese mice, amplification of the daily action of orexin by using orexin agonist in awake period or orexin antagonist in resting period improved glucose metabolism, whereas orexin deficiency caused severe obesity and metabolic abnormalities in the adipose tissue and the liver. Furthermore, orexin and estrogen synergistically prevented obesity-associated metabolic disorders. Thus, homeodynamic regulation of glucose and energy metabolism by hypothalamic orexin system appears to be a key factor for preventing metabolic disorders, including obesity and type 2 diabetes.
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Report
(4 results)
Research Products
(37 results)
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[Journal Article] Timed Inhibition of Orexin System by Suvorexant Improved Sleep and Glucose Metabolism in Type 2 Diabetic db/db Mice.2016
Author(s)
Tsuneki H, Kon K, Ito H, Yamazaki M, Takahara S, Toyooka N, Ishii Y, Sasahara M, Wada T, Yanagisawa M, Sakurai T, Sasaoka T.
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Journal Title
Endocrinology.
Volume: 157
Issue: 11
Pages: 4146-4157
DOI
Related Report
Peer Reviewed
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[Journal Article] Nighttime administration of nicotine improves hepatic glucose metabolism via the hypothalamic orexin system in mice.2016
Author(s)
Tsuneki H, Nagata T, Fujita M, Kon K, Wu N, Takatsuki M, Yamaguchi K, Wada T, Nishijo H, Yanagisawa M, Sakurai T, Sasaoka T.
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Journal Title
Endocrinology
Volume: 157
Issue: 1
Pages: 195-206
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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