| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
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| Outline of Final Research Achievements |
In recent years, brown adipocytes-like tissue is also present in adults, and its effect on the energy consumption of the whole body has been suggested. We found that brown cell-like changes were seen in the white adipose tissue of KO mice of angiogenesis inhibitor THBS1. Furthermore, mitochondrial respiration in adipocytes was elevated in THBS1KO or KD cells. THBS1KO mice capillaries in adipose tissue was increased compared to WT mice. These results strongly suggest the browning change of white adipocytes. In addition, we began to verify based on clinical data obtained by the examination to demonstrate the results obtained in these animal experiments in humans.
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