The elucidation of diabetogenic factors and its interaction in type 2 diabetes

• Project/Area Number: 15K09403
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Metabolomics
• Research Institution: Kindai University
• Principal Investigator: BABAYA Naru 近畿大学, 医学部, 講師 (10449837)
• Co-Investigator(Kenkyū-buntansha): 池上 博司 近畿大学, 医学部, 教授 (20221062) ; 川畑 由美子 近畿大学, 医学部, 准教授 (80423185) ; 能宗 伸輔 近畿大学, 医学部, 講師 (90460849) ; 廣峰 義久 近畿大学, 医学部, 講師 (30460851)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: NSYマウス / コンソミックマウス / 糖尿病疾患感受性遺伝子 / コンジェニックマウス / 疾患感受性遺伝子座

Outline of Final Research Achievements

Type 2 diabetes is multifactorial diseases caused by a complex interaction of multiple susceptibility genes and environmental factors. In this study, we localized the diabetes-related regions in mice. In addition, we constructed the phenotype panel in human. During the course of constructing the panel, a rare case was found and reported (Babaya N, et al., BMC Endocrine Disorders 17、2017、1-6). We also reported the susceptible loci of type 1 diabetes and Grave’s disease (Babaya N, et al., Hum Immunol 78、2017、185-189, and Babaya N, et al., J Clin Endocrinol Metab 100、2015、1976-1983).

Research Products

• [Journal Article] Case report: schwannoma arising from the unilateral adrenal area with bilateral hyperaldosteronism. (2017)
  • Author(s): Babaya N, Makutani Y, Noso S, Hiromine Y, Ito H, Taketomo Y, Ueda K, Ushijima H, Komoike Y, Yamazaki Y, Sasano H, Kawabata Y, Ikegami H.
  • Journal Title: BMC Endocr Disord. Volume: 17 Issue: 1 Pages: 74-74
  • DOI: 10.1186/s12902-017-0225-z
  • Peer Reviewed / Open Access
• [Journal Article] Common phenotype and different non-HLA genes in Graves' disease and alopecia areata (2017)
  • Author(s): Taketomo Y, Noso S, Babaya M, Hiromine Y, Ito H, Kanto K, Niwano F, Oiso N, Kawada A, Kawabata Y, Ikegami H
  • Journal Title: Hum Immunol Volume: 78 Issue: 2 Pages: 185-189
  • DOI: 10.1016/j.humimm.2016.10.019
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Organ specificity in autoimmune diseases: thyroid and islet autoimmunity in alopecia areata. (2015)
  • Author(s): Noso S, Park C, Babaya N, Hiromine Y, Harada T, Ito H, Taketomo Y, Oiso N, Kawada A, Suzuki T, Kawabata Y, Ikegami H
  • Journal Title: J Clin Endocrinol Metab Volume: 100 Issue: 5 Pages: 1976-1983
  • DOI: 10.1210/jc.2014-3985
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Presentation] Identification of Genetic Variants co-segregated with Islet Autoimmunity in Multiplex Families of Type 1 Diabetes by Genome-wide Exome Analysis. (2017)
  • Author(s): Noso S, Hosomichi K, Babaya N, Hiromine Y, Ito H, Taketomo Y, Kawabata Y, Ikegami H
  • Organizer: 15th International Congress of the Immunology of Diabetes Society
  • Place of Presentation: San Francisco, USA (Hyatt Regency Hotel San Francisco)
  • Year and Date: 2017-01-19
  • Int'l Joint Research
• [Presentation] Insulin dependency with and without glucagon: marked difference in insulin requirement between patients with total pancreatectomy and type 1 diabetes (2017)
  • Author(s): Hiromine Y, Noso S, Babaya N, Ito H, Niwano F, Matsumoto I, Takeyama Y, Kawabata Y, Ikegami H
  • Organizer: 53th European Association for the Study of Diabetes Annual Meeting
  • Int'l Joint Research
• [Presentation] Whole-exsome sequencing in rare families identified novel genetic variants for familial type 1 diabetes (2017)
  • Author(s): Noso S, Hosomichi K, Babaya N, Hiromine Y, Ito H, Taketomo Y, Kawabata Y, Ikegami H
  • Organizer: 53th European Association for the Study of Diabetes Annual Meeting
  • Int'l Joint Research
• [Presentation] マウスNSY系統の第11番染色体に存在するストレプトゾトシン誘発糖尿病感受性遺伝子の解析 (2016)
  • Author(s): 前川智樹、小林美里、鈴木京、伊藤美佳子、大野欽司、馬場谷成、上田裕紀、池上博司、堀尾文彦、高橋雅英、大野民生
  • Organizer: 第30回日本糖尿病・肥満動物学会年次学術集会
  • Place of Presentation: 大宮（大宮ソニックシティ）
  • Year and Date: 2016-03-11
• [Presentation] 自然発症２型糖尿病モデルNSYマウス (2016)
  • Author(s): 上田裕紀、馬場谷成、池上博司
  • Organizer: 第30回日本糖尿病・肥満動物学会年次学術集会
  • Place of Presentation: 大宮（大宮ソニックシティ）
  • Year and Date: 2016-03-11
• [Presentation] Identification of genetic loci linked to type 1 diabetes susceptibility by linkage analysis with whole exome sequencing in clustered family. (2015)
  • Author(s): Noso S, Kawabata Y, Babaya N, Hiromine Y, Hosomichi K, Ikegami H
  • Organizer: 14th International Congress of the Immunology of Diabetes Society
  • Place of Presentation: Munich, Germany（Hilton Munich Park）
  • Year and Date: 2015-04-12
  • Int'l Joint Research
• [Remarks] 近畿大学医学部内分泌・代謝・糖尿病内科
  • URL: http://www.med.kindai.ac.jp/emdm/research-content.html
• [Remarks] 近畿大学医学部 内分泌・代謝・糖尿病内科
  • URL: http://www.med.kindai.ac.jp/emdm/research-content.html