Elucidation of the mechanism and clinical application of autoimmune pituitary disease
| Project/Area Number |
15K09431
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Endocrinology
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| Research Institution | Kobe University |
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Principal Investigator |
IGUCHI GENZO 神戸大学, 医学部附属病院, 講師 (60346260)
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| Co-Investigator(Kenkyū-buntansha) |
高橋 裕 神戸大学, 医学研究科, 准教授 (70301281)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 自己免疫性下垂体疾患 / 抗PIT-1抗体症候群 / 腫瘍随伴症候群 |
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| Outline of Final Research Achievements |
We collected a patient with autoimmune pituitary disease, reported one case of male and one case of female case with anti-PIT-1 antibody syndrome, and reported a total of 5 cases.It also revealed that IgG4-related hypophysitis is associated with 5% of IgG4 associated autoimmune pancreatitis.
Thymomas were found in all patients with anti-PIT-1 antibody syndrome and proved to be due to ectopic expression of PIT-1 protein in thymoma cells (Sci Rep. 2017 ). From these result, we proposed a novel concept of thymoma-associated autoimmune disease as a cause of autoimmune pituitary disease.
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Report
(4 results)
Research Products
(26 results)
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[Journal Article] A novel thymoma-associated autoimmune disease: Anti-PIT-1 antibody syndrome.2017
Author(s)
Bando H, Iguchi G, Okimura Y, Odake Y, Yoshida K, Matsumoto R, Suda K, Nishizawa H, Fukuoka H, Mokubo A, Tojo K, Maniwa Y, Ogawa W, Takahashi Y.
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Journal Title
Sci Rep.
Volume: 20
Issue: 1
Pages: 43060-43067
DOI
NAID
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] A diagnostic pitfall in IgG4-related hypophysitis: infiltration of IgG4-positive cells in the pituitary of granulomatosis with polyangiitis.2015
Author(s)
Bando H, Iguchi G, Fukuoka H, Taniguchi M, Kawano S, Saitoh M, Yoshida K, Matsumoto R, Suda K, Nishizawa H, Takahashi M, Morinobu A, Kohmura E, Ogawa W, Takahashi Y.
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Journal Title
Pituitary
Volume: 18
Issue: 5
Pages: 722-730
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] A novel pathogenesis of isolated ACTH deficiency: Paraneoplastic syndrome.2018
Author(s)
Bando H, Iguchi G, Kanie K, Fujita Y, Odake Y, Yoshida K, Matsumoto R, Suda K, Fukuoka H, Ogawa W, Takahashi Y.
Organizer
ENDO 2018 第100回米国内分泌学会議
Related Report
Int'l Joint Research
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[Presentation] 下垂体機能低下症を呈する「抗PIT-1抗体症候群」4例の臨床的検討2016
Author(s)
坂東 弘教, 井口 元三, 小武 由紀子, 吉田 健一, 松本 隆作, 隅田 健太郎, 西澤 衡, 福岡 秀規, 犬塚 恵, 杢保 敦子, 東條 克能, 小川 渉, 高橋 裕
Organizer
第２６回臨床内分泌代謝Update
Place of Presentation
大宮
Year and Date
2016-11-18
Related Report
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[Presentation] 抗PIT-1抗体症候群は新たな胸腺腫関連自己免疫疾患である2016
Author(s)
坂東 弘教, 井口 元三, 福岡 秀規, 小武 由紀子, 吉田 健一, 松本 隆作, 隅田 健太郎, 西沢 衡, 高橋 路子, 杢保 敦子, 東條 克能, 小川 渉, 高橋 裕
Organizer
第８９回日本内分泌学会学術総会
Place of Presentation
京都
Year and Date
2016-04-21
Related Report
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