• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Establishment of pediatric solid tumor development model using human embryonic stem cell differentiation induction system

Research Project

Project/Area Number 15K09651
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Pediatrics
Research InstitutionKyoto University

Principal Investigator

Umeda Katsutsugu  京都大学, 医学研究科, 助教 (80397538)

Research Collaborator NODOMI Seishiro  京都大学, 医学研究科, 医員
KINEHARA Takako  京都大学, 医学研究科, 大学院生
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
KeywordsES細胞 / 小児固形腫瘍 / 神経堤細胞
Outline of Final Research Achievements

CD271high neural crest cells developed during six-day differentiation induction of undifferentiated ES cells under a serum-free condition with Nodal/activin. FCM analysis of surface markers expressed during the neural crest differentiation revealed that various cell lines of pediatric solid tumors expressed CD146. Treatment with a polyclonal antibody against CD146 effectively suppressed in vivo tumor growth of malignant rhabdoid tumor and neuroblastoma cells in immunodeficient mice.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report

URL: 

Published: 2015-04-16   Modified: 2019-03-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi