Establishment of treatment strategies for early-onset inherited arrhythmias based on genotype-phenotype relationships
Project/Area Number |
15K09680
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Pediatrics
|
Research Institution | University of Tsukuba |
Principal Investigator |
|
Research Collaborator |
HORIE Minoru 滋賀医科大学, 医学部, 教授 (90183938)
LIN Lisheng 茨城県立こども病院, 小児循環器科, 医長
KAMEDA Yuri
|
Project Period (FY) |
2015-04-01 – 2018-03-31
|
Project Status |
Completed (Fiscal Year 2017)
|
Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
|
Keywords | 遺伝性不整脈 / 先天性QT延長症候群 / 遺伝子型 / 心電図 / 独立成分分析 / 主成分分析 |
Outline of Final Research Achievements |
Congenital long QT syndrome (LQTS) is considered to be implicated in the development of sudden infant death syndrome (SIDS). Mutation sites of early-onset LQTS (type 2 and 3) were compared with those detected in SIDS victims. The locations were completely different between the two groups for LQT2, and only four mutations overlapped each other for LQT3. These dissociations might be due to difference in vulnerable age, small number of subjects of the study, and that environmental or other factors are required for development of SIDS. T waves in patients with LQTS were evaluated by independent component analysis (ICA) and principle component analysis (PCA) of the data obtained by high-frequency ECG. The number of independent component was 4 in control subjects while 5-7 in LQTS patients. PCA ratios were also significantly higher in LQTS. ICA/ PCA might be useful for detection of heterogeneity of repolarization in LQTS.
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Report
(4 results)
Research Products
(102 results)
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[Journal Article] Standard Values and Characteristics of Electrocardiographic Findings in Children and Adolescents2018
Author(s)
Yoshinaga M, Iwamoto M, Horigome H, Sumitomo N, Ushinohama H, Izumida N, Tauchi N, Yoneyama T, Abe K, Nagashima M
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Journal Title
Circulation Journal
Volume: 82
Issue: 3
Pages: 831-839
DOI
NAID
ISSN
1346-9843, 1347-4820
Related Report
Peer Reviewed / Open Access
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[Journal Article] Antenatal antiarrhythmic treatment for fetal tachyarrhythmias: a study protocol for a prospective multicentre trial2017
Author(s)
Takekazu Miyoshi, Yasuki Maeno, Haruhiko Sago, Noboru Inamura, Satoshi Yasukochi, Motoyoshi Kawataki, Hitoshi Horigome, Hitoshi Yoda, Mio Taketazu, Makio Shozu, Masaki Nii, Akiko Hagiwara, Hitoshi Kato, Wataru Shimizu, Isao Shiraishi, Heima Sakaguchi, Keiko Ueda, Shinji Katsuragi, Tomoaki Ikeda, H Yamamoto, T Hamasaki
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Journal Title
BMJ Open
Volume: 7
Issue: 8
Pages: e016597-e016597
DOI
NAID
Related Report
Peer Reviewed / Open Access
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[Journal Article] The impact of intrauterine treatment on fetal tachycardia: a nationwide survey in Japan2017
Author(s)
Ueda K, Maeno Y, Miyoshi T, Inamura N, Kawataki M, Taketazu M, Nii M, Hagiwara A, Horigome H, Shozu M, Shimizu W, Yasukochi S, Yoda H, Shiraishi I, Sakaguchi H, Katsuragi S, Sago H, Ikeda T; on behalf of Japan Fetal Arrhythmia Group
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Journal Title
J Matern Fetal Neonatal Med
Volume: in press
Issue: 19
Pages: 2605-2610
DOI
Related Report
Peer Reviewed
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[Journal Article] Study design for control of HEART rate in inFant and child tachyarrhythmia with heart failure Using Landiolol (HEARTFUL): A prospective, multicenter, uncontrolled clinical trial2017
Author(s)
Sumitomo N, Horigome H, Miura M, Ono H, Ueda H, Takigiku K, Yoshimoto J, Ohashi N, Suzuki T, Sagawa K, Ushinohama H, Takahashi K, Miyazaki A, Sakaguchi H, Iwamoto M, Takamuro M, Tokunaga C, Nagano T; Heartful Investigators.
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Journal Title
Journal of Cardiology
Volume: inpress
Issue: 3
Pages: 232-237
DOI
Related Report
Peer Reviewed
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[Journal Article] Environmental risk factors for sudden infant death syndrome in Japan2016
Author(s)
Hirabayashi M, Yoshinaga M, Nomura Y, Ushinohama H, Sato S, Tauchi N, Horigome H, Takahashi H, Sumitomo N, Shiraishi H, Nagashima M
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Journal Title
European Journal of Pediatrics
Volume: 175
Issue: 12
Pages: 1921-1926
DOI
Related Report
Peer Reviewed
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[Journal Article] Maternal predictive factors for fetal congenital heart block in pregnant mothers positive for anti-SS-A antibodies.2015
Author(s)
Tsuboi H, Sumida T, Noma H, Yamagishi K, Anami A, Fukushima K, Horigome H, Maeno Y, Kishimoto M, Takasaki Y, Nakayama M, Waguri M, Sago H, Murashima A
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Journal Title
Mod Rheumatol
Volume: Nov 20
Issue: 4
Pages: 1-7
DOI
Related Report
Peer Reviewed
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[Journal Article] Cardiac resynchronization therapy in a patient with a failing systemic right ventricle.2015
Author(s)
Sugano A, Ishizu T, Nakamura A, Kawamatsu N, Kato Y, Takahashi M, Kanemoto S, Seo Y, Horigome H, Hiramatsu Y, Aonuma K
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Journal Title
Can J Cardiol
Volume: 31(6)
Issue: 6
Pages: 819.e5-819.e7
DOI
Related Report
Peer Reviewed
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[Presentation] Targeted Genetic Analysis for Patients with Left Ventricular Dysfunction Complicated with Arrhythmias Using Next-generation Sequencing2018
Author(s)
Murakoshi N, Isaka Y, Lin L, Xu D, Yamasaki H, Yamamoto M, Kuroki K, MachinoT, Yui Y, Sekiguchi Y, Ishizu T, Seo Y, Horigome H, Aonuma K, Nogami A
Organizer
第82回日本循環器学会学術集会
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[Presentation] Sick sinus syndrome caused by HCN4 mutations shows early onset and frequent association with atrial fibrillation and left ventricular non-compaction2017
Author(s)
Ishikawa T, Ohno S, Murakami T, Yoshida K, Fukuoka T, Mishima H, Kimoto H, Aiba T, Nogami A, Sumitomo N, Shimizu W, Horigome H, Yoshiura K, Horie M, Makita N
Organizer
Heart ryhthm 2017
Related Report
Int'l Joint Research
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[Presentation] Screening Japanese School Children for Cardiovascular Disease: Establishing Reference Values of p/QRS Waves on Electrocardiograms for 48,000 Children2017
Author(s)
Horigome H, Nagashima M, Yoshinaga M, Sumitomo N, Tauchi N, Izumida N, Iwamoto M, Ushinohama H, Kato Y, Abe K
Organizer
Heart ryhthm 2017
Related Report
Int'l Joint Research
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[Presentation] Flecainide suppresses an arrhythmogenic substrate in Andersen-Tawil syndrome-induced pluripotent stem cell-derived cardiomyocytes2016
Author(s)
Kuroda Y, Yuasa S, Watanabe Y, Ito S, Egashira T, Seki T, Aizawa Y, Hattori T, Okata S, Tanaka A, Horigome H, Kokubun N, Horie M, Kamiya K, Fukuda K
Organizer
ESC CONGRESS 2016
Place of Presentation
Fiera di Roma (Italy)
Year and Date
2016-08-29
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[Presentation] Efficacy of walking as a lifestyle modification approach for childhood obesity. A randomized controlled trial2016
Author(s)
Yoshinaga M, Ogata H, Aoki M, Ito Y, Hamajima T, Miyazaki A, Tokuda M, Lin L, Horigome H, Takahashi H, Nagashima M
Organizer
ESC CONGRESS 2016
Place of Presentation
Fiera di Roma (Italy)
Year and Date
2016-08-28
Related Report
Int'l Joint Research
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[Presentation] Electrocardiographic (ECG) screening of 1-month-old infants for identifying prolonged QT intervals to prevent sudden infant death2016
Author(s)
Yoshinaga M, Ushinohama H, Nagashima M, Sato S, Hata T, Horigome H, Tauchi N, Nishihara E, Ichida F, Ohno S, Sumitomo N, Iwamoto M
Organizer
ESC CONGRESS 2016
Place of Presentation
Fiera di Roma (Italy)
Year and Date
2016-08-27
Related Report
Int'l Joint Research
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[Presentation] Electrocardiographic(ECG)screening of 1-month-old infants for identifying prolonged QT intervals to prevent sudden infant death2016
Author(s)
Yoshinaga M, Ushinohama H, Nagashima M, Sato S, Hata T, Horigome H, Tauchi N, Nishihara E, Ichida F, Ohno S, Sumitomo N, Iwamoto M, Ogata H, Takahashi H, Horie M, Naoaki Makita N
Organizer
第63回日本不整脈心電学会学術集会
Place of Presentation
札幌コンベンションセンター(北海道札幌市)
Year and Date
2016-07-17
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[Presentation] Six Patients with Ryanodine Receptor type2 Mutation Presenting with the Phenotype of both Catecholaminergic Polymorphic Ventricular Tachycardia and Left Ventricular Noncompaction2016
Author(s)
Nozaki Y, Kato Y, Lin L, Uike K, Yamamura K, Sekiguchi Y, Nogami A, Ohno S, Horie M, Shimizu W, Aonuma K, Horigome H
Organizer
第63回日本不整脈心電学会学術集会
Place of Presentation
札幌コンベンションセンター(北海道札幌市)
Year and Date
2016-07-15
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[Presentation] 胎児頻脈性不整脈に対する経胎盤的抗不整脈薬投与の臨床試験―副作用報告(第2報)―2016
Author(s)
三好 剛一, 前野 泰樹, 左合 治彦, 稲村 昇, 安河内 聰, 川滝 元良, 堀米 仁志, 与田 仁志, 竹田津 未生, 生水 真紀夫, 新居 正基, 白石 公, 坂口 平馬, 上田 恵子, 池田 智明
Organizer
第22回日本胎児心臓病学会学術集会
Place of Presentation
北里大学薬学部1号館・新2号館(東京都港区)
Year and Date
2016-02-19
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[Presentation] 主成分分析と独立成分分析を用いた先天性QT延長症候群のT波の解析 -LQT1とLQT3における解析-2015
Author(s)
堀米 仁志, 高橋 一浩, 石川 康宏, 林 立申, 加藤 愛章, 中村 昭宏, 野崎 良寛, 高橋 実穂, 住友 直方, 岩本 眞理, 吉永 正夫
Organizer
第51回日本小児循環器学会総会・学術集会
Place of Presentation
ホテル日航東京(東京都港区)
Year and Date
2015-07-16
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[Presentation] 心室頻拍を呈し、異なる治療戦略を選択した4新生児例2015
Author(s)
原 モナミ, 林 立申, 今井 綾子, 星野 雄介, 野崎 良寛, 竹内 秀輔, 酒井 愛子, 石川 伸行, 加藤 愛章, 高橋 実穂, 堀米 仁志, 須磨崎 亮
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第109回茨城小児科学会
Place of Presentation
筑波大学イノベーション棟8階講堂(茨城県つくば市)
Year and Date
2015-06-07
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[Presentation] 胎児心磁図により出生前に徐脈・房室ブロック・QT延長の合併を診断された18トリソミーの1例2015
Author(s)
林 立申, 高橋 実穂, 森田 篤志, 永藤 元道, 野崎 良寛, 中村 昭宏, 加藤 愛章, 小関 剛, 小倉 剛, 小畠 真奈, 濱田 洋実, 堀米 仁志
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第30回日本生体磁気学会大会
Place of Presentation
旭川市大雪クリスタルホール(北海道旭川市)
Year and Date
2015-06-05
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[Presentation] 化学療法後小児がん患者の心エコー・スペックルトラッキング法を用いた心機能評価2015
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石川 伸行, 亀田 有里, 堀米 仁志, 加藤 啓輔, 中尾 朋平, 吉見 愛, 村上 卓, 塩野 淳子, 小池 和俊, 土田 昌宏
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第118回日本小児科学会学術集会
Place of Presentation
大阪国際会議場, リーガロイヤルホテル大阪(大阪府大阪市)
Year and Date
2015-04-17
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[Presentation] 洞性徐脈の評価に胎児心磁図が有用であった症例2015
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高尾 航, 大原 玲奈, 眞弓 みゆき, 人見 義郎, 八木 洋也, 安部 加奈子, 永井 優子, 小畠 真奈, 堀米 仁志, 濱田 洋実, 吉川 裕之
Organizer
第67回日本産科婦人科学会学術講演会
Place of Presentation
パシフィコ横浜(神奈川県横浜市)
Year and Date
2015-04-09
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