| Project/Area Number |
15K09696
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Wakayama Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
鈴木 啓之 和歌山県立医科大学, 医学部, 教授 (80196865)
末永 智浩 和歌山県立医科大学, 医学部, 助教 (70433365)
垣本 信幸 和歌山県立医科大学, 医学部, 助教 (90614412)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2015: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
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| Keywords | 川崎病 / シクロスポリンA / 細胞内シグナル伝達 / 炎症性サイトカイン |
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| Outline of Final Research Achievements |
We started a multicenter physician-led trial to compare the utility of IVIG plus cyclosporin A(CsA) combination therapy with the IVIG monotherapy as initial treatment in severe Kawasaki disease(KD). It is a purpose that this study elucidates mechanism of action of IVIG and CsA using a blood sample before and after the initial treatment with CsA for severe KD. Thirteen cases were enrolled in this trial in our hospital. We conducted RNA extraction and serum isolation from the blood sample of these patients and prepared for the measurement of the gene expression level. In total, we measured inflammatory cytokine (sIL-2R,IL2,4,6,10,TNF etc.) for 11 cases 29 points, including IVIG effective cases, resistant cases, IVIG+CsA effective cases, and resistant cases.
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