Investigation of mucosal immune system in relation to pediatric onset gastrointestinal diseases.
| Project/Area Number |
15K09699
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Juntendo University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
清水 俊明 順天堂大学, 医学部, 教授 (30260889)
藤井 徹 順天堂大学, 医学部, 非常勤講師 (30420855)
工藤 孝広 順天堂大学, 医学部, 准教授 (90365601)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 食物アレルギー / 炎症性腸疾患 / ピロリ菌感染胃炎 / CXCL13 / 癌遺伝子 / 消化管アレルギー / 粘膜免疫 / 潰瘍性大腸炎 / クローン病 / シグナル伝達分子 / マイクロアレイ / H. pylori感染症 / H.pylori感染症 |
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| Outline of Final Research Achievements |
The aim of this study was to evaluate gene expression in the H. pylori-infected gastric mucosa of children using microarray and other analyses. Gastric mucosal samples were obtained from antrum and corpus from 24 patients (12 adults and 12 children) who had undergone endoscopic evaluation of chronic abdominal complaints and were examined. Six adult and pediatric patients with and six without (total, 24) H. pylori infection were enrolled.
The expression of inflammatory molecules was up-regulated in the H. pylori-infected gastric mucosa from both adults and children. The expression of OLFM4 was only up-regulated in adult patients, while that of PIM2, REG3A, LCN2 and CXCL 13 was equally up-regulated in the infected gastric mucosa of both.
Because several carcinogenic molecules are up-regulated in H.pylori-infected gastric mucosa even in childhood, early eradication therapy from childhood may be beneficial to decrease the incidence of gastric cancer.
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Report
(4 results)
Research Products
(23 results)
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[Journal Article] Pharmacological inhibition of Notch signaling suppresses food antigen-induced mucosal mast cell hyperplasia.2017
Author(s)
Honjo A, Nakano N, Yamazaki S, Hara M, Uchida K, Kitaura J, Nishiyama C, Yagita H, Ohtsuka Y, Ogawa H, Okumura K, Shimizu T
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Journal Title
J Allergy Clin Immunol.
Volume: 139
Issue: 3
Pages: 987-996
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Treatment with infliximab for pediatric Crohn's disease: Nationwide survey of Japan.2017
Author(s)
Hosoi K, Ohtsuka Y, Fujii T, Kudo T, Matsunaga N, Tomomasa T, Tajiri H, Kunisaki R, Ishige T, Yamada H, Arai K, Yoden A, Ushijima K, Aomatsu T, Nagata S, Uchida K, Takeuchi K, Shimizu T.
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Journal Title
J Gastroenterol Hepatol.
Volume: 32
Issue: 1
Pages: 114-119
DOI
Related Report
Peer Reviewed
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[Journal Article] Immunosuppressive medication is not associated with surgical site infection after surgery for intractable ulcerative colitis in children.2017
Author(s)
Uchida K, Ohtsuka Y, Yoden A, Tajiri H, Kimura H, Isihige T, Yamada H, Arai K, Tomomasa T, Ushijima K, Aomatsu T, Nagata S, Otake K, Matsushita K, Inoue M, Kudo T, Hosoi K, Takeuchi K, Shimizu T.
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Journal Title
Intractable Rare Dis Res.
Volume: 6
Issue: 2
Pages: 106-113
DOI
NAID
Related Report
Peer Reviewed
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[Journal Article] Comparison of Gene Expression Between Pediatric and Adult Gastric Mucosa with Helicobacter pylori Infection.2016
Author(s)
Obayashi N, Ohtsuka Y, Hosoi K, Ikuse T, Jimbo K, Aoyagi Y, Fujii T, Kudo T, Asaoka D, Hojo M, Nagahara A, Watanabe S, Shimizu T.
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Journal Title
Helicobacter
Volume: 21
Issue: 2
Pages: 114-123
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Eosinophilic gastroenteritis in a patient with Bruton's tyrosine kinase deficiency.2016
Author(s)
Yamazaki S, Ohtsuka Y, Yokokura T, Yokota R, Honjo A, Inage E, Baba Y, Mori M, Suzuki R, Iwata T, Shimizu T.
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Journal Title
Pediatr Int.
Volume: 58
Issue: 5
Pages: 417-419
DOI
Related Report
Peer Reviewed
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