Detection of the Intrinsic factors affecting on skin aging
| Project/Area Number |
15K09747
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Dermatology
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| Research Institution | University of the Ryukyus |
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Principal Investigator |
Takahashi Kenzo 琉球大学, 医学(系)研究科(研究院), 教授 (80291425)
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| Research Collaborator |
YAMAGUCHI Sayaka
UTSUMI Daisuke
OOKUBO Yuko
OMINE Takuya
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 皮膚老化 / 中枢性老化 / 血清因子 / 並立結合 / 外因性老化 / 内因性老化 / 老化因子 / 並立接合マウス / 紫外線 / 持続炎症 / アンチエージング / 臓器老化 / 血中因子 / ヒアルロン酸 |
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| Outline of Final Research Achievements |
Mouse skin aging was analyzed by comprehensively comparing gene expression on the skin of parallel mice between elderly and young mice as well as examining the skin of mice of each age, very old, old, young mice by RNA microarray. It was confirmed that genes belonging to early responsive gene including fos, fos-B, atf3, Jun, Jun-B, egr-1, are elevated along with aging, and it is also induced in young mice by serum factor transfer from old mice in parabiotic experiments. The expression of the PTGS2 gene was strongly enhanced as in the aging mice, similarly to the AP1 binding proteins. Thus, it was understood that some factor acts on epidermal keratinocytes, and results in the induction of COX 2 and Caspase 1, and the sustained chronic inflammation on the skin leads to the skin damage and aging.
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Report
(4 results)
Research Products
(69 results)
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[Journal Article] Survivin: A novel marker and potential therapeutic target for human angiosarcoma.2017
Author(s)
Tsuneki M, Kinjo T, Mori T, Yoshida A, Kuyama K, Ohira A, Miyagi T, Takahashi K, Kawai A, Chuman H, Yamazaki N, Masuzawa M, Arakawa H.
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Journal Title
Cancer Sci.
Volume: 108
Issue: 11
Pages: 2295-2305
DOI
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Peer Reviewed / Open Access
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[Journal Article] Infiltration of PD-1-positive cells in combination with tumor site PD-L1 expression is a positive prognostic factor in cutaneous angiosarcoma.2017
Author(s)
Honda Y, Otsuka A, Ono S, Yamamoto Y, Seidel JA, Morita S, Hirata M, Kataoka TR, Takenouchi T, Fujii K, Kanekura T, Okubo Y, Takahashi K, Yanagi T, Hoshina D, Hata H, Abe R, Fujimura T, Funakoshi T, Yoshino K, Masuzawa M, Amoh Y, Tanaka R, Fujisawa Y, Honda T, Kabashima K.
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Journal Title
Oncoimmunology.
Volume: 6
Issue: 1
Pages: e1253657-e1253657
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Peer Reviewed / Open Access
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[Journal Article] A randomized double-blind trial of intravenous2016
Author(s)
Amagai M, Ikeda S, Hashimoto T, Mizuashi M, Fujisawa A, Ihn H, Matsuzaki Y, Ohtsuka M, Fujiwara H, Furuta J, Tago O, Yamagami J, Tanikawa A, Uhara H, Morita A, Nakanishi G, Tani M, Aoyama Y, Makino E, Muto M, Manabe M, et al.
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Journal Title
J Dermatol Sci
Volume: 85（2）
Issue: 2
Pages: 77-84
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Peer Reviewed / Open Access
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[Journal Article] Conspicuous Bilateral Eyelids Swelling Appeared in a Patient with Subcutaneous Panniculitis-like T-cell Lymphoma2015
Author(s)
林 健太郎, 宮城 拓也, 園崎 哲, 山口 さやか, 山本 雄一, 高橋 健造, 西 由希子, 仲地 佐和子, 友寄 毅昭, 益崎 裕章, 上里 博
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Journal Title
Nishi Nihon Hifuka
Volume: 77
Issue: 5
Pages: 487-491
DOI
NAID
ISSN
0386-9784, 1880-4047
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Peer Reviewed / Open Access
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[Journal Article] 先天性Bednar腫瘍の1例2015
Author(s)
林 健太郎, 仲村 郁心, 眞鳥 繁隆, 粟澤 剛, 山本 雄一, 苅谷 嘉之, 高橋 健造, 上里 博
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Journal Title
日本小児皮膚科学会雑誌
Volume: 34
Pages: 131-135
Related Report
Peer Reviewed / Open Access
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[Journal Article] Novel compound heterozygous DNA ligase IV mutations in an adolescent with a slowly-progressing radiosensitive-severe combined immunodeficiency2015
Author(s)
Tamura S, Higuchi K, Tamaki M, Inoue C, Awazawa R, Mitsuki N, Nakazawa Y, Mishima H, Takahashi K, Kondo O, Imai K, Morio T, Ohara O,et al
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Journal Title
Clin Immunol
Volume: 160
Issue: 2
Pages: 255-260
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Peer Reviewed / Open Access
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[Journal Article] Increasing trends in cervical cancer mortality among young Japanese women below the age of 50 years: an analysis using the Kanagawa population-based Cancer Registry, 1975-2012.2015
Author(s)
Motoki Y, Mizushima S, Taguri M, Takahashi K, Asano R, Kato H, Asai-Sato M, Katayama K, Okamoto N, Hirahara F, Miyagi E.
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Journal Title
Cancer Epidemiol
Volume: 39
Issue: 5
Pages: 700-706
DOI
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Peer Reviewed / Open Access
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