Molecular mechanism regulating circadian rhythms and mood
| Project/Area Number |
15K09817
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | National Center of Neurology and Psychiatry |
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Principal Investigator |
Hida Akiko 国立研究開発法人国立精神・神経医療研究センター, 精神保健研究所精神生理研究部, 室長 (20333354)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 生物時計 / 睡眠障害 / 概日リズム / 培養細胞 / リポーター遺伝子 / 遺伝子 |
|---|
| Outline of Final Research Achievements |
We evaluated the circadian phenotypes of patients with delayed sleep-wake phase disorder (DSWPD) and non-24-hour sleep-wake rhythm disorder (N24SWD), two different circadian rhythm sleep-wake disorders (CRSWDs) by measuring Bmal1-luciferase (Bmal1-luc) rhythms in fibroblast cells derived from individual patients (in vitro rhythms). The period length of the Bmal1-luc rhythm (in vitro period) varied among individuals.The N24SWD group showed a significantly longer in vitro period than did the control or DSWPD group. Furthermore, in vitro period was associated with response to chronotherapy in the N24SWD group. Longer in vitro periods were observed in the non-responders compared to the responders in the N24SWD group. In vitro rhythm assays could be useful for predicting circadian phenotypes and clinical prognosis in patients with CRSWDs.
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Report
(4 results)
Research Products
(14 results)
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[Journal Article] Evaluation of circadian phenotypes utilizing fibroblasts from patients with circadian rhythm sleep disorders2017
Author(s)
A Hida, Y Ohsawa, S Kitamura, K Nakazaki, N Ayabe, Y Motomura, K Matsui, M Kobayashi, A Usui, Y Inoue, H Kusanagi, Y Kamei, K Mishima
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Journal Title
Transl Psychiatry
Volume: 7
Issue: 4
Pages: e1106-e1106
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Presentation] 概日リズム睡眠障害の治療反応性と末梢時計リズム周期2017
Author(s)
1.肥田昌子, 北村真吾, 中﨑恭子, 綾部直子, 元村祐貴, 加藤美恵, 松井健太郎, 小林美奈, 碓氷章, 井上雄一, 草薙宏明, 亀井雄一, 三島和夫
Organizer
日本睡眠学会第42回定期学術集会
Related Report
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[Presentation] 睡眠相後退型、フリーラン型の抹消時計リズム周期2016
Author(s)
肥田昌子, 北村真吾, 中﨑恭子, 綾部直子, 元村祐貴, 加藤美恵, 松井健太郎, 小林美奈, 碓氷章, 井上雄一, 草薙宏明, 亀井雄一, 三島和夫
Organizer
日本睡眠学会第41回定期学術集会
Place of Presentation
東京、京王プラザホテル
Year and Date
2016-07-07
Related Report
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[Presentation] 日本人集団における概日リズム睡眠障害の多型解析2015
Author(s)
肥田昌子, 北村真吾, 片寄泰子, 加藤美恵, 小野浩子, 角谷寛, 内山真, 海老沢尚, 井上雄一, 亀井雄一, 大川匡子, 高橋清久, 三島和夫
Organizer
第37回日本生物学的精神医学会
Place of Presentation
東京、タワーホール船堀
Year and Date
2015-09-24
Related Report
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[Presentation] 概日リズム障害とPER3反復配列・OPN4多型の関連解析2015
Author(s)
肥田昌子, 北村真吾, 片寄泰子, 加藤美恵, 小野浩子, 角谷寛, 内山真, 海老沢尚, 井上雄一, 亀井雄一, 大川匡子, 高橋清久, 三島和夫
Organizer
日本睡眠学会第40回定期学術集会
Place of Presentation
栃木、栃木県総合文化センター
Year and Date
2015-07-03
Related Report
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