Event related potential study in first episode schizophrenia using mismatch negativity

• Project/Area Number: 15K09823
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: The University of Tokyo
• Principal Investigator: ARAKI TSUYOSHI 東京大学, 医学部附属病院, 講師 (00456120)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 統合失調症 / 事象関連電位 / リスク期 / ミスマッチ院生電位 / 持続時間MMN / 周波数MMN / 初発期 / MMN

Outline of Final Research Achievements

Duration and frequency mismatch negativity were recorded for subjects (first episode schizophrenia patients, ultra high risk patients and healthy controls). Cross sectional study showed that duration MMN is impaired in patients groups. Longitudinal study showed that these MMN do not change for 1 to 2 years.
Duration mismatch negativity can be a biological marker for early stage schizophrenia.

Research Products

• [Journal Article] Duration and frequency mismatch negativity shows no progressive reduction in early stages of psychosis (2017)
  • Author(s): Koshiyama D, Kirihara K, Tada M, Nagai T, Koike S, Suga M, Araki T, Kasai K
  • Journal Title: Schizophrenia Research Volume: 印刷中 Pages: 32-38
  • DOI: 10.1016/j.schres.2017.03.015
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Intact neural activity during a Go/No-go task is associated with high global functioning in schizophrenia. (2016)
  • Author(s): Araki T, Kirihara K, Koshiyama D, Nagai T, Tada M, Fukuda M, Kasai K.
  • Journal Title: Psychiatry Clin Neurosci Volume: Epub ahead of print Issue: 7 Pages: 278-285
  • DOI: 10.1111/pcn.12389
  • Peer Reviewed
• [Presentation] 統合失調症の事象関連電位；MMNを中心に (2017)
  • Author(s): 荒木剛、切原賢治、越山太輔、永井達哉、多田真理子、藤岡真生、笠井清登
  • Organizer: 第47回日本臨床神経生理学会学術大会
• [Presentation] 統合失調症のMMN (2016)
  • Author(s): 荒木剛
  • Organizer: 第46回日本臨床神経生理学会
  • Place of Presentation: 福島
• [Presentation] リスク期・初発統合失調症患者のMMN (2015)
  • Author(s): 荒木剛 切原賢治 永井達哉 多田真理子 越山大輔 笠井清登
  • Organizer: 臨床神経生理学会
  • Place of Presentation: 大阪国際会議場（大阪府・大阪市）
  • Year and Date: 2015-11-05