Development of supplementary laboratory test for the differential diagnosis of depression
Project/Area Number |
15K09832
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Psychiatric science
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Research Institution | Yamaguchi University |
Principal Investigator |
MATSUO Koji 山口大学, 大学院医学系研究科, 准教授 (00292912)
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Co-Investigator(Kenkyū-buntansha) |
山形 弘隆 山口大学, 医学部附属病院, 講師 (10549934)
藤田 悠介 山口大学, 大学院創成科学研究科, 准教授 (40509527)
松原 敏郎 山口大学, 大学教育機構, 准教授 (60526896)
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Project Period (FY) |
2015-04-01 – 2018-03-31
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Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
Keywords | 神経画像 / MRI / 遺伝子 / 脳体積 / 遺伝子発現 / うつ病 / 双極性障害 / 気分障害 / 前部帯状回 / 島領域 / エンドフェノタイプ |
Outline of Final Research Achievements |
We examined biological marker for the differential diagnosis of depression and bipolar disorder using MR imaging and gene expression. We found that patients with depression showed abnormal gray matter volume and white matter integrity of frontal and temporal regions. Patients with depression demonstrated abnormal gene expressions, which were observed in depression-like mice. These findings are suggested to be potentially biomarker for the differential diagnosis of depression and bipolar disorder.
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Report
(4 results)
Research Products
(23 results)
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[Journal Article] Abnormal asymmetries in subcortical brain volume in schizophrenia.2016
Author(s)
Okada, N.;Nemoto, K.;Hibar, D. P.;van Erp, T. G.;Fujino, H.;Isobe, M.;Isomura, S.;Natsubori, T.;Narita, H.;Hashimoto, N.;Miyata, J.;Koike, S.; Suzuki, M.;Turner, J. A.; Ozaki, N.;Kasai, K.;Hashimoto, R.
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Journal Title
Mol Psychiatry
Volume: -
Issue: 10
Pages: 1460-6
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Disrupted orbitomedial prefrontal limbic network in individuals with later-life depression2016
Author(s)
Harada K, Matsuo K, Nakashima M, Hobara T, Higuchi N, Higuchi F, Nakano M, Otsuki K, Shibata T, Watanuki T, Matsubara T, Fujita Y, Shimoji K, Yamagata H, Watanabe Y
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Journal Title
Journal of Affective Disorders
Volume: 204
Pages: 112-119
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Blood transcriptomic markers in patients with late-onset major depressive disorder2016
Author(s)
Miyata S, Kurachi M, Okano Y, Sakurai N, Kobayashi A, Harada K, Yamagata H, Matsuo K, Takahashi K, Narita K, Fukuda M, Ishizaki Y, Mikuni M
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Journal Title
PLoS One
Volume: 11
Issue: 2
Pages: e0150262-e0150262
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] Different fronto-temporal activation during emotional and cognitive tasks in patients with unipolar and bipolar depression: A functional near-infrared spectroscopy study.2016
Author(s)
Matsubara T, Matsuo K, Harada K, Nakashima M, Nakano M, Hirotsu M, Hirata K, Higuchi N, Watanuki T, Higuchi F, Yamagata H, Watanabe Y
Organizer
18th Annual Conference of the International Society for Bipolar Disorders Held Jointly with the 8th Biennial Conference of the International Society for Affective Disorders
Place of Presentation
Amsterdam, The Netherlands
Year and Date
2016-07-13
Related Report
Int'l Joint Research
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[Presentation] Structural and functional brain abnormalities in patients with late-life depression: a longitudinal MRI study of multiple imaging analysis.2016
Author(s)
Harada K, Matsuo K, Nakashima M, Hobara T, Higuchi N, Higuchi F, Nakano M, Otsuki K, Shibata T, Watanuki T, Ikuta T, Matsubara T, Yamagata H, Watanabe Y
Organizer
18th Annual Conference of the International Society for Bipolar Disorders Held Jointly with the 8th Biennial Conference of the International Society for Affective Disorders
Place of Presentation
Amsterdam, The Netherlands
Year and Date
2016-07-13
Related Report
Int'l Joint Research
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[Presentation] Distinct and shared morphometric biomarkers of depressed individuals with bipolar disorder and major depressive disorder2016
Author(s)
Matsuo K, Fujita Y, Harada K, Inoue T, Kunugi H, Kusumi I, Narita H, Okada G, Okamoto Y, Ota M, Takamura M, Watanabe Y, Yamagata H, Yamawaki S
Organizer
30th CINP World Congress of Neuropsychopharmacology
Place of Presentation
Seoul, Korea
Year and Date
2016-07-03
Related Report
Int'l Joint Research
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[Presentation] Distinction of brain morphometric abnormalities in bipolar and unipolar depression: A voxel-based multi-center study2015
Author(s)
Matsuo K, Harada K, Okamoto Y, Ohta M, Narita H, Fujita Y, Okada G, Takamura M, Yamagata H, Kusumi I, Inoue T, Kunugi H, Yamawaki S, Watanabe Y
Organizer
Neuroscience 2015
Place of Presentation
Chicago, USA
Year and Date
2015-10-17
Related Report
Int'l Joint Research
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[Presentation] Different fronto-temporal activation during an emotional word task in patients with unipolar and bipolar depression: A functional near-infrared spectroscopy study2015
Author(s)
Matsubara T, Matsuo K, Harada K, Nakashima M, Nakano M, Hirotsu M, Hirata K, Higuchi N, Watanuki T, Higuchi F, Otsuki K, Shibata T, Hobara T, Yamagata H, Watanabe Y
Organizer
Society of Biological Psychiatry 70th Annual Meeting
Place of Presentation
Toronto, Canada
Year and Date
2015-05-14
Related Report
Int'l Joint Research
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[Presentation] Reduced Gray-matter Volume of Fronto-temporal Cortex in Patients with Late-life Depression2015
Author(s)
Harada K, Matsuo K, Yamagata H, Nakashima M, Nakano M, Higuchi N, Higuchi F, Hobara T, Otsuki K, Shibata T, Watanuki T, Ueda K, Furukawa M, Fukunaga M, Fujita Y, Shimoji K, Matubata T, Matsunaga N, Watanabe Y
Organizer
Society of Biological Psychiatry 70th Annual Meeting
Place of Presentation
Toronto, Canada
Year and Date
2015-05-14
Related Report
Int'l Joint Research