A neuroimaging study exploring the biological differences between Hoarding Disorder , Obsessive-Compulsive Disorder and Anxiety Disorder
| Project/Area Number |
15K09834
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
村山 桂太郎 九州大学, 大学病院, 助教 (20645981)
樋渡 昭雄 九州大学, 大学病院, 助教 (30444855)
實松 寛晋 九州大学, 医学研究院, 共同研究員 (30588116)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | ためこみ症 / Hoarding Disorder / OCD / prefrontal cortex / VBM / MRI / Hoaring disorder / パニック症 / 画像解析 / 神経心理 |
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| Outline of Final Research Achievements |
Seventeen patients who met the DSM-5 criteria for HD(Hoarding disorder), 17 obsessive-compulsive disorder (OCD) patients, and 17 healthy controls (HCs) participated in this study. All participants underwent MRI scanning of the brain by a 3.0-Tesla MRI scanner. In a voxel-based morphometric procedure, preprocessed GM structural images were used to compare the three groups.
The average age of the 3 groups was HD: 43.9±11.5, OCD: 39.9±9.0, HCs: 42.4±10.4 respectively. In the results of VBM analyses, all three groups (HD, OCD, and HCs) exhibited the presence of significant regional GM volume differences in the right prefrontal regions.
As with OCD, HD is considered to have cognitive dysfunction as its basis. This result is convincing after considering the clinical features of HD and suggested that structural abnormalities in the prefrontal regions might relate to the pathophysiology of HD.
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Report
(4 results)
Research Products
(24 results)
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[Journal Article] A transcultural study of hoarding disorder: Insights from the United Kingdom, Spain, Japan, and Brazil.2018
Author(s)
Ashley E. Nordsletten, Lorena Fernandez de la Cruz, Elena Aluco Pino Alonso, Clara Lopez-Sola, Jose M. Menchon, Tomohiro Nakao, Masumi Kuwano, Satoshi Yamada, Leonardo F. Fontenelle, Andre Luis Campos-Lima, David Mataix-Cols
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Journal Title
Transcultural Psychiatry
Volume: 55
Issue: 2
Pages: 261-285
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] ENIGMA OCD Working Group, Thompson PM, Stein DJ, van den Heuvel OA: Distinct Subcortical Volume Alterations in Pediatric and Adult OCD: A Worldwide Meta- and Mega-Analysis2017
Author(s)
Boedhoe PS, Schmaal L, Abe Y,..., Ikari K, ..., Mataix-Cols D, Menchon JM, Minuzzi L, Nakamae T, Nakao T, ..., Pittenger C, Reddy YC, Sato JR, Simpson HB, Soreni N, Soriano-Mas C, Spalletta G, Stevens MC, Szeszko PR, Tolin DF, Venkatasubramanian G, Walitza S, Wang Z, van Wingen GA, Xu J, Xu X, Yun JY, Zhao Q
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Journal Title
American Journal of Psychiatry
Volume: 174
Pages: 60-69
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] A pilot study exploring the association of morphological changes with 5-HTTLPR polymorphism in OCD patients2017
Author(s)
Honda S, Nakao T, Mitsuyasu T, Okada K, Gotoh L, Tomita M, Sanematsu H, Murayama K, Ikari K, Kuwano M, Yoshiura T, Kawasaki H, Kanba S;
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Journal Title
Annals of General Psychiatry
Volume: 16:2
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Current viewpoints on DSM-5 in Japan2016
Author(s)
Kuroki T, Ishitobi M, Kamio Y, Sugihara G, Murai T, Motomura K, Ogasawara K, Kimura H, Aleksic B, Ozaki N, Nakao T, Yamada K, Yoshiuchi K, Kiriike N, Ishikawa T, Kubo C, Matsunaga C, Miyata H, Asada T, Kanba S
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Journal Title
Psychiatry and Clinical Neuroscience
Volume: 70
Pages: 371-393
Related Report
Peer Reviewed / Acknowledgement Compliant
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