A neuroimaging study exploring the biological differences between Hoarding Disorder , Obsessive-Compulsive Disorder and Anxiety Disorder

• Project/Area Number: 15K09834
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: Kyushu University
• Principal Investigator: Nakao Tomohiro 九州大学, 大学病院, 講師 (50423554)
• Co-Investigator(Kenkyū-buntansha): 村山 桂太郎 九州大学, 大学病院, 助教 (20645981) ; 樋渡 昭雄 九州大学, 大学病院, 助教 (30444855) ; 實松 寛晋 九州大学, 医学研究院, 共同研究員 (30588116)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: ためこみ症 / Hoarding Disorder / OCD / prefrontal cortex / VBM / MRI / Hoaring disorder / パニック症 / 画像解析 / 神経心理

Outline of Final Research Achievements

Seventeen patients who met the DSM-5 criteria for HD(Hoarding disorder), 17 obsessive-compulsive disorder (OCD) patients, and 17 healthy controls (HCs) participated in this study. All participants underwent MRI scanning of the brain by a 3.0-Tesla MRI scanner. In a voxel-based morphometric procedure, preprocessed GM structural images were used to compare the three groups.
The average age of the 3 groups was HD: 43.9±11.5, OCD: 39.9±9.0, HCs: 42.4±10.4 respectively. In the results of VBM analyses, all three groups (HD, OCD, and HCs) exhibited the presence of significant regional GM volume differences in the right prefrontal regions.
As with OCD, HD is considered to have cognitive dysfunction as its basis. This result is convincing after considering the clinical features of HD and suggested that structural abnormalities in the prefrontal regions might relate to the pathophysiology of HD.

Research Products

• [Journal Article] A transcultural study of hoarding disorder: Insights from the United Kingdom, Spain, Japan, and Brazil. (2018)
  • Author(s): Ashley E. Nordsletten, Lorena Fernandez de la Cruz, Elena Aluco Pino Alonso, Clara Lopez-Sola, Jose M. Menchon, Tomohiro Nakao, Masumi Kuwano, Satoshi Yamada, Leonardo F. Fontenelle, Andre Luis Campos-Lima, David Mataix-Cols
  • Journal Title: Transcultural Psychiatry Volume: 55 Issue: 2 Pages: 261-285
  • DOI: 10.1177/1363461518759203
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] ENIGMA OCD Working Group, Thompson PM, Stein DJ, van den Heuvel OA: Distinct Subcortical Volume Alterations in Pediatric and Adult OCD: A Worldwide Meta- and Mega-Analysis (2017)
  • Author(s): Boedhoe PS, Schmaal L, Abe Y,..., Ikari K, ..., Mataix-Cols D, Menchon JM, Minuzzi L, Nakamae T, Nakao T, ..., Pittenger C, Reddy YC, Sato JR, Simpson HB, Soreni N, Soriano-Mas C, Spalletta G, Stevens MC, Szeszko PR, Tolin DF, Venkatasubramanian G, Walitza S, Wang Z, van Wingen GA, Xu J, Xu X, Yun JY, Zhao Q
  • Journal Title: American Journal of Psychiatry Volume: 174 Pages: 60-69
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] A pilot study exploring the association of morphological changes with 5-HTTLPR polymorphism in OCD patients (2017)
  • Author(s): Honda S, Nakao T, Mitsuyasu T, Okada K, Gotoh L, Tomita M, Sanematsu H, Murayama K, Ikari K, Kuwano M, Yoshiura T, Kawasaki H, Kanba S;
  • Journal Title: Annals of General Psychiatry Volume: 16:2
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Current viewpoints on DSM-5 in Japan (2016)
  • Author(s): Kuroki T, Ishitobi M, Kamio Y, Sugihara G, Murai T, Motomura K, Ogasawara K, Kimura H, Aleksic B, Ozaki N, Nakao T, Yamada K, Yoshiuchi K, Kiriike N, Ishikawa T, Kubo C, Matsunaga C, Miyata H, Asada T, Kanba S
  • Journal Title: Psychiatry and Clinical Neuroscience Volume: 70 Pages: 371-393
  • Peer Reviewed / Acknowledgement Compliant
• [Presentation] ためこみ症(HD:Hoarding Disorder)の臨床的特徴 (2017)
  • Author(s): 山田聖、中尾智博
  • Organizer: 日本不安症学会
  • Place of Presentation: 福岡
  • Year and Date: 2017-03-10
• [Presentation] ためこみ症の理解と治療 (2017)
  • Author(s): 中尾智博
  • Organizer: 日本不安症学会
  • Place of Presentation: 福岡
  • Year and Date: 2017-03-10
• [Presentation] Gray matter structural changes in Hoarding disorder; preliminary study (2017)
  • Author(s): Satoshi Yamada, Tomohiro Nakao, Keitaro Murayama, Keisuke Ikari, Masumi Kuwano, Hirofumi Tomiyama, Shigenobu Kanba
  • Organizer: WPA ⅩⅦ WORLD CONGRESS OF PSYCHIATRY BERLIN 2017
  • Int'l Joint Research
• [Presentation] The clinical features of Japanese patients with Hording Disorder. (2017)
  • Author(s): Nakao T, Yamada S, Murayama K, Kuwano M
  • Organizer: ISAD Conference 2017. The International Society of Affective Disorders
  • Int'l Joint Research
• [Presentation] 強迫症・ためこみ症の臨床研究 (2017)
  • Author(s): 中尾智博
  • Organizer: 第19回八ヶ岳シンポジウム
• [Presentation] ためこみ症（Hoarding Disorder: HD）の臨床的背景および認知機能について (2017)
  • Author(s): 山田聖, 桑野真澄, 猪狩圭介, 豊見山泰史, 村山桂太郎, 中尾智博
  • Organizer: 第17回精神疾患と認知機能研究会
• [Presentation] 強迫関連症の脳画像研究 (2017)
  • Author(s): 中尾智博
  • Organizer: 中尾智博
• [Presentation] ためこみ症の臨床と研究 (2016)
  • Author(s): 中尾智博
  • Organizer: 医療心理懇話会
  • Place of Presentation: 東京
  • Year and Date: 2016-11-03
• [Presentation] ためこみ症の背景と治療的介入について (2015)
  • Author(s): 桑野真澄、中尾智博
  • Organizer: 第41回日本認知・行動療法学会
  • Place of Presentation: 仙台
  • Year and Date: 2015-10-02
• [Presentation] A morphometric study into the pathophysiology of obsessive- compulsive disorder (2015)
  • Author(s): Nakao T
  • Organizer: The 38th Annual Meeting of the Japan Neuroscience Society
  • Place of Presentation: 神戸
  • Year and Date: 2015-07-28
• [Presentation] Neurobiological heterogeneities of OCD. Symposium: Biological approaches toward clarifying heterogeneities of obsessive-compulsive disorder (2015)
  • Author(s): Nakao T
  • Organizer: 12th WFSBP
  • Place of Presentation: アテネ、ギリシャ
  • Year and Date: 2015-06-14
  • Int'l Joint Research
• [Presentation] The association of serotonin and/or dopamine system genes and gray matter volume in OCD (2015)
  • Author(s): Honda S
  • Organizer: WPA REGIONAL CONGRESS OSAKA JAPAN 2015
  • Place of Presentation: 大阪
  • Year and Date: 2015-06-04
• [Book] DSM-5の強迫関連症群の概要と臨床的意義. 精神科治療学 (2017)
  • Author(s): 中尾智博
  • Total Pages: 6
  • Publisher: 星和書店
• [Book] 物をためこむ症状を診分ける. 精神科治療学 (2017)
  • Author(s): 中尾智博、蓮澤優
  • Total Pages: 5
  • Publisher: 星和書店
• [Book] 溜め込み癖に関する疫学調査及び治療的介入の試み. メンタルヘルス岡本記念財団研究助成報告集 (2016)
  • Author(s): 桑野真澄、中尾智博
  • Total Pages: 4
  • Publisher: メンタルヘルス岡本記念財団
• [Book] ため込み症の病理と治療. メンタルクリニックでの主要な疾患への対応［2］ (2016)
  • Author(s): 中尾智博
  • Total Pages: 5
  • Publisher: 中山書店
• [Book] ためこみ症. 臨床精神医学 (2016)
  • Author(s): 中尾智博
  • Total Pages: 3
  • Publisher: アークメディア
• [Book] ためこみ症の病態と治療—OCD・ADHDとの関連性も含めて. 臨床精神薬理 (2015)
  • Author(s): 中尾智博、桑野真澄
  • Total Pages: 8
  • Publisher: 星和書店
• [Book] 強迫性障害（OCD）と認知機能障害. 精神科治療学 (2015)
  • Author(s): 中尾智博
  • Total Pages: 8
  • Publisher: 星和書店
• [Book] 強迫性障害の神経基盤. 臨床精神医学 (2015)
  • Author(s): 本田慎一、中尾智博
  • Total Pages: 9
  • Publisher: アークメディア