An examination of novel typological approach in obsessive-compulsive spectrum disorders based on the findings regarding neurofunctional validity of the disorders.
| Project/Area Number |
15K09845
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Hyogo Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
中嶋 章浩 兵庫医科大学, 医学部, 病院助手 (00739229)
向井 馨一郎 兵庫医科大学, 医学部, 病院助手 (70739218)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
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| Keywords | 強迫性障害 / 強迫スペクトラム障害 / 前頭葉機能検査 / 神経発達運動障害 / 治療抵抗性 / 目的志向性行動 / 近赤外線スペクトロスコピー / fMRI / 強迫スペクトラム / 異種性 / 前頭葉機能 / チック関連性 |
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| Outline of Final Research Achievements |
There is increasing evidence that obsessive-compulsive spectrum disorder (OCSD), especially obsessive-compulsive disorder (OCD) is a heterogeneous condition. For instance, recent factor analyses have provided cross-culturally consistent evidence that distinct OC symptom dimensions exist. These symptom dimensions have been differentially related to clinical features such as comorbidity. Our studies revealed that comorbid conditions might exert crucial effects on the prefrontal cortex activities along with long-term-treatment outcome of OCD.
To overcome the limitations of current pharmacotherapy for OCD, evaluations should focus on psychopathological features, such as comorbid disorders, or temporal transition of the brain mechanism according to the chronicity of OCD such as that from goal-directed to habitual nature of compulsions. The consideration of such cross-sectional and longitudinal heterogeneity of OCSD may be crucial to developing more effective treatments for the disorders.
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Report
(4 results)
Research Products
(81 results)
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[Journal Article] Physiological and molecular effects of interleukin-18 administration on the mouse kidney.2018
Author(s)
Yamanishi K, Mukai K, Hashimoto T, Ikubo K, Nakasho K, Darawish Y, Li W, Okuzaki D, Watanabe Y, Hayakawa T, Nojima H, Yamanishi H, Okamura H, Matsunaga H.
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Journal Title
Journal of Translational Medicine
Volume: 16(1)
Issue: 1
Pages: 51-51
DOI
Related Report
Peer Reviewed
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[Journal Article] Comorbidity, age of onset, suicidality in obsessive-compulsive disorder (OCD); An international collaboration.2017
Author(s)
Brakoulias V, Starcevic V, Belloch A, Brown C, Ferrao YA, Fontenelle LF, Lochner C, Marazziti D, Matsunaga H, Miguel EC, Reddy YCJ, do Rosario MC, Shavitt RG, Shyam Sundar A, Stein D J, Torres A R, Viswasam K.
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Journal Title
Comprehensive Psychiatry
Volume: 76
Pages: 79-86
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Interleukin-18-deficient mice develop dyslipidemia resulting in non-alcoholic fatty liver disease and steatohepatitis.2016
Author(s)
Yamanishi K, Maeda S, Kuwahara-Otani S, Watanabe Y, Yoshida M, Ikubo K, Okuzaki D, El-Darawish Y, Li W, Nakasho K, Nojima H, Yamanishi H, Hayakawa T, Okamura H, Matsunaga H.
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Journal Title
Translational Research
Volume: 173
Pages: 101-114
Related Report
Peer Reviewed
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[Journal Article] The classification of Obsessive-Compulsive and Related Disorders in the ICD-112016
Author(s)
Stein D.J., Kogan C.S., Atmaca M., Fineberg N.A, Fontenelle L.F., Grant J, Matsunaga H, Reddy Y.C.J, Simpson H.B, Thomsen P.H, van den Heuvel O.A, Veale D, Woods D.W, Reed G.M.
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Journal Title
J Affect Disord
Volume: 190
Pages: 663-674
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Standards of care for obsessive-compulsive disorder centres2016
Author(s)
Menchón JM, van Ameringen M, Dell’Osso B, Denys D, Figee M, Grant J, Hollander E, Marazitti D, Nicolini H, Pallanti S, Ruck C, Shavitt R, Stein D, Andersson E, Bakim B, Bipeta R, Cath DC, Drummond L, Feusner J, Geller DA, Hranov G, Karadag F, Kenezloi E, Lochner C, Matsunaga H, Mpavaenda D, Nakamae T, etc.
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Journal Title
Int J Clin Psychiatr Pract
Volume: 20(3)
Issue: 3
Pages: 204-208
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Hepatocyte nuclear factor 4 alpha is a key factor related to depression and physiological homeostasis in the mouse brain.2015
Author(s)
Yamanishi K, Doe N, Sumida M, Watanabe Y, Yoshida M, Yamamoto H, Xu Y, Li W, Yamanishi H, Okamura H, Matsunaga H.
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Journal Title
PLoS ONE
Volume: 10
Issue: 3
Pages: e0119021-e0119021
DOI
Related Report
Peer Reviewed
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[Presentation] Interleukin-18 deficit mice develop hippocampal abnormalities resulting in depression-like behavior.2017
Author(s)
Yamanishi K Doe N, Mukai K, Uwa N, Ikubo K, Hashimoto T, Sumida M, Kuwahara-Otani S, Maeda S, Watanabe Y, Li W, Hayakawa T, Okamura H, Matsunaga H.
Organizer
WPA XVII World Congress of Psychiatry
Related Report
Int'l Joint Research / Invited
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[Presentation] Interleukin-18-deficient mice develop dysfunction of hippocampus resulting in d2016
Author(s)
Yamanishi K, Doe N, Kaoru Ikubo1, Sumida M, Kuwahara-Otani S, Maeda S, WatanabeY, Yoshida M, Li W, Hayakawa T, Okamura H, Yamanishi H, Matsunaga H.
Organizer
30th CINP World Congress of Neuropsychopharmacology
Place of Presentation
Seoul, Republic of Korea.
Year and Date
2016-07-03
Related Report
Int'l Joint Research
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[Presentation] Molecular analysis of neural action mediated by the antipsychotic drug olanzapine in high glucose exposure.2016
Author(s)
Ikubo K, Yamanishi K, Kuwahara-Otani S, Maeda S, Li W, Watanabe Y, Yoshida M, Hayakawa T, Okamura H, Yamanishi H, Matsunaga H.
Organizer
30th CINP World Congress of Neuropsychopharmacology.
Place of Presentation
Seoul, Republic of Korea.
Year and Date
2016-07-03
Related Report
Int'l Joint Research
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