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Establishment and analysis of a mouse model of treatment-resistant autism comorbid with ADHD

Research Project

Project/Area Number 15K09873
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Psychiatric science
Research InstitutionWakayama Medical University

Principal Investigator

HISAOKA TOMOKO  和歌山県立医科大学, 医学部, 助教 (00398463)

Co-Investigator(Kenkyū-buntansha) 森川 吉博  和歌山県立医科大学, 医学部, 教授 (60230108)
Co-Investigator(Renkei-kenkyūsha) KITAMURA TOSHIO  東京大学, 医科学研究所, 教授 (20282527)
KOMORI TADASUKE  和歌山県立医科大学, 医学部, 講師 (90433359)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords精神発達障害 / 自閉症スペクトラム障害 / シナプス / 注意欠如・多動性障害 / 神経科学 / 自閉症スペクトラム障害 (ASD) / 注意欠陥・多動性障害 (ADHD) / 細胞接着分子 / 注意欠陥・多動性障害
Outline of Final Research Achievements

In recent studies, it has been suggested that Kirrel3 is an autism-associated gene. We generated Kirrel3-knockout (KO) mice and investigated their behavioral phenotypes relevant to autism spectrum disorder (ASD). Kirrel3-KO mice exhibited ASD-like behaviors with hyperactivity. In addition, we observed abnormal synaptic organization in the cerebellum and accessory olfactory bulb in Kirrel3-KO mice. These results suggest that the abnormal synapse formation of cerebellum and accessory olfactory bulb in Kirrel3-KO mice may induce abnormal synaptic activity, which cause ASD-like behaviors with hyperactivity. It remains unknown which neural circuits are impaired in the patients with treatment-resistant autism comorbid with attention deficit hyperactivity disorder (ADHD). Kirrel3-KO mice may be represented a mouse model of ASD comorbid with ADHD and could provide molecular and pathophysiological information for ASD comorbid with ADHD.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (7 results)

All 2018 2017 2016

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (6 results) (of which Int'l Joint Research: 2 results)

  • [Journal Article] Abnormal behaviours relevant to neurodevelopmental disorders in Kirrel3-knockout mice2018

    • Author(s)
      Hisaoka T, Komori T, Kitamura T, Morikawa Y
    • Journal Title

      Scientific Reports

      Volume: 8 Issue: 1 Pages: 1408-1408

    • DOI

      10.1038/s41598-018-19844-7

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] シナプス形成期の脳におけるKirrel3の発現とその欠損マウスにおける発達期のコミュニケーション異常2018

    • Author(s)
      久岡朋子、小森忠祐、北村俊雄、森川吉博
    • Organizer
      第123回日本解剖学会総会・全国学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 脳におけるkirrel3の局在とその欠損による行動異常2017

    • Author(s)
      久岡朋子、小森忠祐、形部裕昭、北村俊雄、森川吉博
    • Organizer
      第122回日本解剖学会
    • Place of Presentation
      長崎大学坂本キャンパス(長崎県、長崎市)
    • Year and Date
      2017-03-30
    • Related Report
      2016 Research-status Report
  • [Presentation] Deficiency of kirrel3, a synaptic cell adhesion molecule, results in behaviors relevant to ASD with ADHD2017

    • Author(s)
      Tomoko Hisaoka, Tadasuke Komori, Hiroaki Gyobu, Toshio Kitamura, Yoshihiro Morikawa
    • Organizer
      A Keystone Symposium (Synapses and Circuits joint with the conference on Connectomics))
    • Place of Presentation
      Santa Fe, New Mexico, USA
    • Year and Date
      2017-03-06
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Further characterization of autistic-like behaviors in kirrel3-knockout mice2017

    • Author(s)
      Hisaoka T, Komori T, Gyobu H, Kitamura T, Morikawa Y
    • Organizer
      第60回日本神経化学会大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Autistic-like behaviors with hyperactivity in mice lacking kirrel32016

    • Author(s)
      Tomoko Hisaoka, Tadasuke Komori, Hiroaki Gyobu, Toshio Kitamura, Yoshihiro Morikawa
    • Organizer
      The 46th Annual Meeting of the Society for Neuroscience
    • Place of Presentation
      San Diego, California, USA
    • Year and Date
      2016-11-14
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] kirrel3遺伝子欠損マウスは注意欠陥・多動性障害(ADHD)を伴う自閉症様行動を示す2016

    • Author(s)
      久岡朋子、小森忠祐、形部裕昭、北村俊雄、森川吉博
    • Organizer
      第59回日本神経化学会大会(第38回日本生物学的精神医学会との合同大会)
    • Place of Presentation
      福岡国際会議場(福岡県、福岡市)
    • Year and Date
      2016-09-09
    • Related Report
      2016 Research-status Report

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Published: 2015-04-16   Modified: 2019-03-29  

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