Establishment and analysis of a mouse model of treatment-resistant autism comorbid with ADHD
| Project/Area Number |
15K09873
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Wakayama Medical University |
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Principal Investigator |
HISAOKA TOMOKO 和歌山県立医科大学, 医学部, 助教 (00398463)
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| Co-Investigator(Kenkyū-buntansha) |
森川 吉博 和歌山県立医科大学, 医学部, 教授 (60230108)
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| Co-Investigator(Renkei-kenkyūsha) |
KITAMURA TOSHIO 東京大学, 医科学研究所, 教授 (20282527)
KOMORI TADASUKE 和歌山県立医科大学, 医学部, 講師 (90433359)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 精神発達障害 / 自閉症スペクトラム障害 / シナプス / 注意欠如・多動性障害 / 神経科学 / 自閉症スペクトラム障害 (ASD) / 注意欠陥・多動性障害 (ADHD) / 細胞接着分子 / 注意欠陥・多動性障害 |
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| Outline of Final Research Achievements |
In recent studies, it has been suggested that Kirrel3 is an autism-associated gene. We generated Kirrel3-knockout (KO) mice and investigated their behavioral phenotypes relevant to autism spectrum disorder (ASD). Kirrel3-KO mice exhibited ASD-like behaviors with hyperactivity. In addition, we observed abnormal synaptic organization in the cerebellum and accessory olfactory bulb in Kirrel3-KO mice. These results suggest that the abnormal synapse formation of cerebellum and accessory olfactory bulb in Kirrel3-KO mice may induce abnormal synaptic activity, which cause ASD-like behaviors with hyperactivity. It remains unknown which neural circuits are impaired in the patients with treatment-resistant autism comorbid with attention deficit hyperactivity disorder (ADHD). Kirrel3-KO mice may be represented a mouse model of ASD comorbid with ADHD and could provide molecular and pathophysiological information for ASD comorbid with ADHD.
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Report
(4 results)
Research Products
(7 results)
