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Non-contrast breast MRI using molecular imaging of the breast with CEST-MRI

Research Project

Project/Area Number 15K09921
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Radiation science
Research InstitutionKyoto University

Principal Investigator

KATAOKA MASAKO  京都大学, 医学研究科, 助教 (10611577)

Co-Investigator(Kenkyū-buntansha) 金尾 昌太郎  京都大学, 医学研究科, 助教 (80542216)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
KeywordsBreast cancer / MRI / CEST / non contrast / Breast / Cancer
Outline of Final Research Achievements

Amide proton transfer(APT) Chemical Exchange Saturation Transfer(CEST)MRI is a state- of-the-art technique to detect low concentration amide molecule, and thus can indicate the concentration of mobile protein in our body. We hypothesized that APT CEST can reveal new information. Our result suggested that “hyperintensity rim on CEST MRI” is characteristic to the breast cancer. The rim may be seen in the pre treatment image and disappear. We also developed a quick version of CEST-MRI. The results will be presented in the coming academic meeting.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (10 results)

All 2018 2017 2016 2015

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (8 results) (of which Int'l Joint Research: 7 results)

  • [Journal Article] The Value of Lesion Size as an Adjunct to the BI-RADS-MRI 2013 Descriptors in the Diagnosis of Solitary Breast Masses2018

    • Author(s)
      Kawai M, Kataoka M, Kanao S, Iima M, Onishi N, Ohashi A, Sakaguchi R, Toi M, Togashi K.
    • Journal Title

      Magnetic Resonance in Medical Sciences

      Volume: 17 Issue: 3 Pages: 203-210

    • DOI

      10.2463/mrms.mp.2017-0024

    • NAID

      130007403794

    • ISSN
      1347-3182, 1880-2206
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Differentiating benign and malignant inflammatory breast lesions: Value of T2 weighted and diffusion weighted MR images2018

    • Author(s)
      Shotaro Kanao, Masako Kataoka, Mami Iima, Debra Masako Ikeda, Masakazu Toi, Kaori Togashi
    • Journal Title

      Magnetic Resonance Imaging

      Volume: 50 Pages: 38-44

    • DOI

      10.1016/j.mri.2018.03.012

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Presentation] Synthetic biomarkers using IVIM and non-Gaussian diffusion MRI: diagnostic performance and comparison with BI-RADS categories in differentiation of malignant/ benign breast tumors2017

    • Author(s)
      Iima M, Kataoka M, Kanao S, Onishi N, Kawai M, Ohashi A, Sakaguchi R, Ohno AK, Togashi K.
    • Organizer
      European Congress of Radiology
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Quantitative non-Gaussian diffusion and IVIM MRI: Correlation between synthetic parameters and breast cancer biomarkers2017

    • Author(s)
      Iima M, Kataoka M, Kanao S, Onishi N, Kawai M, Ohashi A , Sakaguchi R, Kishimoto AO, Toi M, Togashi K
    • Organizer
      The 25th Annual Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] How to Best Utilize T2-weighted MR Images of the Breast: Diagnostic Algorithm of T2-high SI area based on Location, Enhancement Pattern, and ADC Value.2016

    • Author(s)
      Onishi N, Kataoka M, Kanao S, Kawai M, Toi M, Iima M, Ohashi A, Sakaguchi R, Kishimoto O A. Togashi K
    • Organizer
      Radiological Society of North America
    • Place of Presentation
      Chicago, IL, USA
    • Year and Date
      2016-11-27
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] How to Make Use of Non-fat-suppressed Precontrast T1-weighed Image in Breast MRI: Systematic Approach to Diagnosis with the Emphasis of Fat Signal Intensity2016

    • Author(s)
      Kawai M, Kataoka M, Kanao S, Onishi N, Iima M, Ohashi A, Sakaguchi R, Kishimoto O A, Toi M, Togashi K.
    • Organizer
      Radiological Society of North America
    • Place of Presentation
      Chicago, IL, USA
    • Year and Date
      2016-11-27
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] RESOLVEを用いた高分解能拡散強調画像による腫瘍の治療前評価:高分解能造影ダイナミック画像との比較2016

    • Author(s)
      片岡正子 金尾昌太郎 飯間麻美 大西奈都子、河合真喜子、大橋茜、阪口怜奈、戸井雅和 富樫かおり
    • Organizer
      第24回日本乳癌学会学術総会 東京2016.6.16-18
    • Place of Presentation
      東京
    • Year and Date
      2016-06-16
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Amide proton transfer (APT) imaging of breast cancer at 3T MRI: a pilot study2016

    • Author(s)
      Onishi N, Kataoka M, Kanao S, Iima M, Kawai M, Ohashi A, Murata K, Schmitt B, Togashi K
    • Organizer
      The 24th Annual Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine
    • Place of Presentation
      Singapole
    • Year and Date
      2016-05-09
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] High resolution diffusion-weighted MRI with readout-segmented echo-planar imaging and computed DWI as a potential alternative of high resolution dynamic contrast-enhanced MRI in evaluating breast cancer.2016

    • Author(s)
      Kataoka M, Kanao S, Iima M, Onishi N, Kawai M, Ohashi A, Toi M, Togashi K.
    • Organizer
      The 24th Annual Scientific Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine
    • Place of Presentation
      Singapore
    • Year and Date
      2016-05-07
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Non-Gaussian Diffusion MRI in Evaluation of Early Treatment Effects during Neoadjuvant Treatment for Breast Cancer2015

    • Author(s)
      Iima M,Ogino R, Kataoka M, Nagao S, Kanao S, Ohashi A, Kawai M,Onishi N, Togashi K, Le Bihan D
    • Organizer
      第74回日本医学放射線学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2015-04-16
    • Related Report
      2015 Research-status Report

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Published: 2015-04-16   Modified: 2019-03-29  

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