Development of early diagnosis methods for uterine sarcoma by hemorrhage/necrosis imaging based on susceptibility-weighted sequences and MR spectroscopy

• Project/Area Number: 15K09927
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: The University of Tokushima
• Principal Investigator: TAKEUCHI Mayumi 徳島大学, 病院, 講師 (90423417)
• Co-Investigator(Kenkyū-buntansha): 松崎 健司 徳島文理大学, 保健福祉学部, 教授 (70274222)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: MRI / 子宮肉腫 / MRスペクトロスコピー / 出血イメージング / 壊死イメージング / 磁化率強調像 / 機能画像 / 出血 / 壊死 / lipid

Outline of Final Research Achievements

Uterine corpus tumors were evaluated by MRI and MR spectroscopy (MRS) at 3T. Hemorrhage imaging by using susceptibility-weighted MR sequences could reveal intra-tumoral hemorrhage in uterine sarcomas with high sensitivity compared to the conventional MR images. Necrosis imaging by using MRS demonstrated low choline concentration reflecting decreased cellularity and high lipid concentration reflecting increased necrosis-associated mobile lipid droplets. We concluded that the combination of hemorrhage imaging and necrosis imaging may be useful for the early diagnosis of uterine sarcomas.

Research Products

• [Journal Article] Carcinosarcoma of the uterus: MRI findings including diffusion-weighted imaging and MR spectroscopy. (2016)
  • Author(s): Takeuchi M, Matsuzaki K, Harada M.
  • Journal Title: Acta Radiol. Volume: [Epub ahead of print]
  • Peer Reviewed
• [Presentation] Diagnostic strategy for uterine sarcomas: Imaging manifestations, pitfalls, and problem-solving MR techniques (2018)
  • Author(s): Takeuchi M, Matsuzaki K, Harada M.
  • Organizer: European Society of Radiology
  • Int'l Joint Research
• [Presentation] Clinical utility of susceptibility-weighted MR sequence (SWAN) for the evaluation of uterine sarcomas (2018)
  • Author(s): Takeuchi M, Matsuzaki K, Harada M.
  • Organizer: International Society for Magnetic Resonance in Medicine
  • Int'l Joint Research
• [Presentation] Clinical impact of susceptibility-weighted MR sequences in the female pelvis (2017)
  • Author(s): Takeuchi M, Matsuzaki K, Harada M.
  • Organizer: ECR
  • Place of Presentation: ウィーン（オーストリア）
  • Year and Date: 2017-03-01
  • Int'l Joint Research
• [Presentation] Red degeneration of uterine leiomyoma: Clinical utility of susceptibility-weighted MR imaging (2017)
  • Author(s): Takeuchi M, Matsuzaki K, Harada M.
  • Organizer: International Society for Magnetic Resonance in Medicine
  • Int'l Joint Research
• [Presentation] Many faces of uterine leiomyomas: Usual, unusual imaging manifestations, pitfalls, and problem-solving MR techniques (2017)
  • Author(s): Takeuchi M, Matsuzaki K, Harada M.
  • Organizer: Radiological Society of North America
  • Int'l Joint Research
• [Presentation] Diagnostic impact of susceptibility-weighted MR sequences in the female pelvis (2016)
  • Author(s): Takeuchi M, Matsuzaki K, Harada M.
  • Organizer: RSNA
  • Place of Presentation: シカゴ（USA）
  • Year and Date: 2016-11-27
  • Int'l Joint Research
• [Presentation] Cystic uterine lesions: Wide spectrum of clinical and imaging manifestations, pitfalls, and problem-solving MR techniques (2016)
  • Author(s): Takeuchi M, Matsuzaki K, Harada M.
  • Organizer: RSNA
  • Place of Presentation: シカゴ（USA）
  • Year and Date: 2016-11-27
  • Int'l Joint Research
• [Presentation] Clinical application of susceptibility-weighted MR sequences in the female pelvis (2016)
  • Author(s): Takeuchi M, Matsuzaki K, Harada M.
  • Organizer: ISMRM
  • Place of Presentation: シンガポール（シンガポール）
  • Year and Date: 2016-05-07
  • Int'l Joint Research
• [Presentation] Clinical application of susceptibility-weighted MR sequences in the female pelvis (2016)
  • Author(s): Takeuchi M, Matsuzaki K, Harada M.
  • Organizer: 国際磁気共鳴医学会（ISMRM）
  • Place of Presentation: Suntec city (シンガポール)
  • Year and Date: 2016-05-07
  • Int'l Joint Research
• [Presentation] Diagnostic imaging for gynecological malignancies with perspective on prognostic prediction: Uterine sarcoma (2016)
  • Author(s): Takeuchi M
  • Organizer: 日本医学放射線学会総会
  • Place of Presentation: パシフィコ横浜（神奈川県・横浜市）
  • Year and Date: 2016-04-14
  • Invited
• [Presentation] 女性骨盤部領域における磁化率強調像の臨床応用 (2016)
  • Author(s): 竹内麻由美、松崎健司、原田雅史
  • Organizer: 日本医学放射線学会
  • Place of Presentation: パシフィコ横浜 (神奈川県横浜市)
  • Year and Date: 2016-04-14
• [Presentation] シンポジウム 婦人科腫瘍の予後予測と治療戦略に向けての画像診断：子宮肉腫 (2016)
  • Author(s): 竹内麻由美
  • Organizer: 日本医学放射線学会
  • Place of Presentation: パシフィコ横浜 (神奈川県横浜市)
  • Year and Date: 2016-04-14
  • Invited
• [Presentation] Diagnostic and Therapeutic Strategy for Uterine Sarcomas by Advanced MR Techniques (2015)
  • Author(s): Takeuchi M, Matsuzaki K, Harada M.
  • Organizer: 北米放射線学会 (RSNA)
  • Place of Presentation: Chicago (USA)
  • Year and Date: 2015-11-29
  • Int'l Joint Research