Impact of cardiac beta-adrenergic receptor density evaluated by cardiac PET on chronotropic incompetence

• Project/Area Number: 15K09966
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: Nagoya City University
• Principal Investigator: Goto Toshihiko 名古屋市立大学, 大学院医学研究科, 講師 (50596905)
• Research Collaborator: KIKUCHI SHOHEI 名古屋市立大学, 大学院 医学研究科心臓・腎高血圧内科学, 助教 (90771709) ; IIDA AKIHIKO 名古屋市総合リハビリテーションセンター, 放射線科部長 ; NARITA HITOMI 名古屋市総合リハビリテーションセンター, 内科部長 ; ITO YOSHIMARO 名古屋市総合リハビリテーションセンター, 運営企画室, 放射線取扱主任、診療放射線技師 ; HAYASHI EMI 名古屋市総合リハビリテーションセンター, 運営企画室, 診療放射線技師
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000); Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: 変時性不全 / PET / β受容体 / β受容体密度 / 心臓交感神経β受容体

Outline of Final Research Achievements

Chronotropic incompetence, defined as the inability of the heart to increase its rate commensurate with increased activity, produces exercise intolerance, and is an independent predictor of overall mortality. The cardiac sympathetic β adrenergic receptor density in patients with chronotropic incompetence was evaluated using cardiac PET using positron tracer [C11] CGP-12177 which is a ligand of the sympathetic β adrenergic receptor. In patients with chronotropic incompetence, the β adrenergic receptor density was decreased, and the decrease of cardiac β adrenergic receptor density, which is located in the post synapse was related as a cause of it. This study may help better understanding of the mechanism of chronotropic incompetence.

Research Products

• [Presentation] Impact of cardiac beta-adrenergic receptor density evaluated by cardiac PET on chronotropic incompetence. (2018)
  • Author(s): Toshihiko Goto, Syohei Kikuchi, Kent Mori, Marina Kato, Kosuke Nakasuka, Kazuaki Wakami, Hidekatu Fukuta, Hitomi Narita, Akihiko Iida, Ohte Nobuyuki
  • Organizer: The 82th Annual Scientific Meeting of the Japanese Circulation Society
• [Presentation] Impact of cardiac beta-adrenergic receptor density evaluated by cardiac PET on chronotropic incompetence. (2017)
  • Author(s): Toshihiko Goto, Syohei Kikuchi, Kent Mori, Marina Kato, Kazuaki Wakami, Hidekatu Fukuta, Hitomi Narita, Akihiko Iida, Ohte Nobuyuki
  • Organizer: AHA Scientific Sessions, 2017, Anaheim
  • Int'l Joint Research
• [Presentation] Impact of cardiac beta-adrenergic receptor density evaluated by cardiac PET on chronotropic incompetence. (2017)
  • Author(s): Toshihiko Goto, Syohei Kikuchi, Kent Mori, Marina Kato, Hitomi Narita, Akihiko Iida, Ohte Nobuyuki.
  • Organizer: Europace Cardiostim 2017, Austria
  • Int'l Joint Research