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Study on the abscopal effect in Boron Neutron Capture Therapy

Research Project

Project/Area Number 15K09993
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Radiation science
Research InstitutionKyoto University

Principal Investigator

Kinashi Yuko  京都大学, 複合原子力科学研究所, 准教授 (80252534)

Project Period (FY) 2015-10-21 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywordsホウ素中性子捕捉療法 / 中性子 / アブスコパル効果 / DNA損傷 / 分割照射
Outline of Final Research Achievements

To investigate whether the radiation-sensitivity of the individual influence the abscopal effect following the neutron radiation, the value of Oral Radiation Death after head-neutron-irradiation and the index of apoptosis of non-irradiated splenic cells were studied about high-radiation sensitive mice, so-called SCID mice. The RBE (relative biological effectiveness) values that show the radiation sensitivity of SCID mice were slightly lower than inbred C3H mice. These results indicate that the abscopal effect of radio-sensitive mice will not appear high following neutron irradiation.

Academic Significance and Societal Importance of the Research Achievements

がんの放射線治療では放射線治療後に白血球のうちのリンパ球数が低下するとともに免疫能が低下する。中性子照射によるホウ素中性子捕捉療法では腫瘍選択性が高く正常組織に対する副作用は低く抑えられるが、中性子照射後の免疫反応については知見が少ない。中性子照射後の免疫組織である脾細胞の応答についての研究成果はBNCTプラス免疫療法のための適正なプロトコルの提案が可能となる。

Report

(5 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (11 results)

All 2018 2017 2016 2015

All Journal Article (4 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 4 results,  Acknowledgement Compliant: 1 results) Presentation (7 results) (of which Int'l Joint Research: 4 results)

  • [Journal Article] DNA Double-strand Breaks Induced by Fractionated Neutron Beam Irradiation for Boron Neutron Capture Therapy2017

    • Author(s)
      Yuko Kinashi, Natsuya Yokomizo, Sentaro Takahashi
    • Journal Title

      ANTICANCER RESEARCH

      Volume: 37 Issue: 4 Pages: 1681-1685

    • DOI

      10.21873/anticanres.11499

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] DNA double-strand breaks induced by fractionated neutron beam irradiation for boron neutron capture therapy2017

    • Author(s)
      Y.Kinashi, N.Yokomizo, S.Takahashi
    • Journal Title

      Anticancer research

      Volume: 37 Pages: 1681-1685

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] The influence of p53 status in glioblastoma on the effect of boron neutron capture therapy2015

    • Author(s)
      K.Seki, Y.Kinashi, S.Takahashi
    • Journal Title

      Anticancer Research

      Volume: 35 Pages: 169-174

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] A comparative study of the biological effects of neutron beams woth different energy profiles2015

    • Author(s)
      E.Kitajima, S.Takahashi, Y.Kinashi, Y.Kubota, R.Okayasu, H.Tanaka, M.Takada, K.Ono
    • Journal Title

      RADIOISOTOPES

      Volume: 64 Pages: 291-297

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Presentation] The combination effect of neutron irradiation and exposure to DNA-alkylating agent on glioblastoma cell lines with different MGMT and p53 status2018

    • Author(s)
      Yuko Kinashi, Tomoyuki Ikawa, Sentaro Takahashi
    • Organizer
      18th International Congress on Neutron Capture Therapy
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] エックス線感受性の異なるマウスにおける中性子感受性の差2018

    • Author(s)
      木梨友子、小野公二
    • Organizer
      日本放射線影響学会 第61回大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Cell Survival and DNA-double-strand breaks in Glioblastoma Call Lines with Different p53 Status after Neutron Irradiation and Exposure to DNA-alkylating Agent2017

    • Author(s)
      Rui Akayama, Yuko Kinashi, Kayoko Iwata, Sota Tanaka, Sentaro Takahashi
    • Organizer
      9th Young Researchers' BNCT Meeting
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] p53遺伝子の発現が異なる神経膠芽腫細胞における中性子照射感受性およびDNAアルキル化剤感受性2017

    • Author(s)
      木梨友子、赤山類、井川智之、高橋千太郎
    • Organizer
      日本放射線影響学会第60回大会
    • Related Report
      2017 Research-status Report
  • [Presentation] 53BP1を指標とした中性子のDNA二重鎖切断損傷・修復の特徴2016

    • Author(s)
      木梨友子、井川智之、高橋千太郎
    • Organizer
      日本放射線影響学会第59回大会
    • Place of Presentation
      JMSアステールプラザ、広島
    • Year and Date
      2016-10-26
    • Related Report
      2016 Research-status Report
  • [Presentation] The DNA double-strand breaks damage in CHO cells induced by the fractionated neutron irradiation2016

    • Author(s)
      Y.Kinashi, N.Yokomizo, T.Ikawa, S.Takahashi
    • Organizer
      International Congress on Neutron Capture Therapy
    • Place of Presentation
      University of Missouri, Colombia,Missouri,USA
    • Year and Date
      2016-10-02
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] The DNA double-strand breaks damage in CHO cwlls induced by the fractionated neutron irradiation2016

    • Author(s)
      Yuko Kinashi, Natsuya Yokomozo, Sentaro Takahashi
    • Organizer
      17th International Congress on Neutron Capture Therapy
    • Place of Presentation
      University of Missouri, Colombia, Missouri, USA
    • Year and Date
      2016-10-02
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research

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Published: 2015-10-21   Modified: 2020-03-30  

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