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The development of novel chemoradiotherapy using synthetic lethality by DNA repair inhibitors for esophageal cancer

Research Project

Project/Area Number 15K10101
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Digestive surgery
Research InstitutionHiroshima University

Principal Investigator

Hamai Yoichi  広島大学, 病院(医), 講師 (90423384)

Co-Investigator(Kenkyū-buntansha) 岡田 守人  広島大学, 原爆放射線医科学研究所, 教授 (70446045)
Research Collaborator EMI MANABU  広島大学, 原爆放射線医科学研究所, 助教 (30464308)
IBUKI YUTA  広島大学, 病院, 医科診療医 (40581369)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
KeywordsDNA修復阻害
Outline of Final Research Achievements

We evaluated the antitumor effects of anticancer drug, PARP inhibitor (Olaparib) and irradiation to esophageal cancer cell lines. Furthermore, we verified the combinational effects of anticancer drug, PARP inhibitor and irradiation. These anticancer effects were also evaluated in condition using RNAi for RAD51. Moreover. we could revealed the mechanism in expression and enhancement of anticancer effect by over time evaluation of γH2AX and RAD51 under these treatments for esophageal cancer cell lines. We aim to develop novel chemoradiotherapy using synthetic lethality by DNA repair inhibitors for PARP and RAD51 in esophageal cancer in the future.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (20 results)

All 2018 2017 2016 2015 2014

All Journal Article (14 results) (of which Peer Reviewed: 14 results,  Open Access: 3 results) Presentation (6 results) (of which Int'l Joint Research: 2 results)

  • [Journal Article] Preoperative prediction of a pathologic complete response of esophageal squamous cell carcinoma to neoadjuvant chemoradiotherapy2018

    • Author(s)
      Hamai Y, Hihara J, Emi M, Furukawa T, Murakami Y, Nishibuchi I, Nagata Y, Ibuki Y, Yamakita I, Kurokawa T, Okada M
    • Journal Title

      Surgery

      Volume: - Issue: 1 Pages: 40-48

    • DOI

      10.1016/j.surg.2018.01.011

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Evaluation of Prognostic Factors for Esophageal Squamous Cell Carcinoma Treated with Neoadjuvant Chemoradiotherapy Followed by Surgery2018

    • Author(s)
      Hamai Y, Hihara J, Emi M, Furukawa T, Murakami Y, Nishibuchi I, Ibuki Y, Yamakita I, Kurokawa T, Nagata Y, Okada M
    • Journal Title

      World J Surg

      Volume: 42 Issue: 5 Pages: 1496-1505

    • DOI

      10.1007/s00268-017-4283-1

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Treatment Outcomes and Prognostic Factors After Recurrence of Esophageal Squamous Cell carcinoma2017

    • Author(s)
      Hamai Y, Hihara J, Emi M, Furukawa T, Ibuki Y, Yamakita I, Kurokawa T, Okada M
    • Journal Title

      World J Surg

      Volume: Epub ahead of print Issue: 7 Pages: 2190-2198

    • DOI

      10.1007/s00268-017-4430-8

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clinicopathologic Features of Submucosal Esophageal Squamous Cell Carcinoma2017

    • Author(s)
      Emi M, Hihara J, Hamai Y, Furukawa T, Ibuki Y, Okada M
    • Journal Title

      Ann Thorac Surg

      Volume: 104 Issue: 6 Pages: 1858-1864

    • DOI

      10.1016/j.athoracsur.2017.06.037

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of Neoadjuvant Chemoradiotherapy on Pathological TNM Stage and Their Prognostic Significance for Surgically-treated Esophageal Squamous Cell Carcinoma2017

    • Author(s)
      Hamai Y, Hihara J, Emi M, Furukawa T, Ibuki Y, Yamakita I, Kurokawa T, Okada M
    • Journal Title

      Anticancer Res

      Volume: 37 Pages: 5639-5646

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Role of Postoperative C-Reactive Protein Levels in Predicting Prognosis After Surgical Treatment of Esophageal Cancer2017

    • Author(s)
      Ibuki Y, Hamai Y, Hihara J, Emi M, Taomoto J, Furukawa T, Yamakita I, Kurokawa T, Okada M
    • Journal Title

      World J Surg

      Volume: in press Issue: 6 Pages: 1558-1565

    • DOI

      10.1007/s00268-017-3900-3

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Role of definitive chemoradiotherapy using docetaxel and 5-fluorouracil in patients with unresectable locally advanced esophageal squamous cell carcinoma: a phase II study.2016

    • Author(s)
      Hihara J, Hamai Y, Emi M, Murakami Y, Kenjo M, Nagata Y, Okada M.
    • Journal Title

      Dis Esophagus

      Volume: in press Issue: 8 Pages: 1115-20

    • DOI

      10.1111/dote.12433

    • Related Report
      2016 Research-status Report 2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Ability of Fluorine-18 Fluorodeoxyglucose Positron Emission Tomography to Predict Outcomes of Neoadjuvant Chemoradiotherapy Followed by Surgical Treatment for Esophageal Squamous Cell Carcinoma2016

    • Author(s)
      Hamai Y, Hihara J, Emi M, Furukawa T, Yamakita I, Kurokawa T, Okada M
    • Journal Title

      Ann Thorac Surg

      Volume: 102 Issue: 4 Pages: 1132-9

    • DOI

      10.1016/j.athoracsur.2016.04.011

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Surgical Resection of Thoracic Esophageal Cancer with Interstitial Lung Disease: A Case Report2016

    • Author(s)
      Ibuki Y, Hamai Y, Hihara J, Taomoto J, Furukawa T, Yamakita I, Okada M
    • Journal Title

      Hiroshima J Med Sci

      Volume: 65 Pages: 19-23

    • NAID

      120005743718

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Clinical Significance of FDG-PET to Predict Pathologic Tumor Invasion and Lymph Node Metastasis of Superficial Esophageal Squamous Cell Carcinoma2016

    • Author(s)
      Furukawa T, Hamai Y, Hihara J, Emi M, Yamakita I, Ibuki Y, Okada M
    • Journal Title

      Ann Surg Oncol

      Volume: 23 Pages: 4086-92

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Laparoscopic Repair and Percutaneous Endoscopic Gastrostomy to Treat Giant Esophageal Hiatal Hernia with Gastric Obstruction: A Case Report.2015

    • Author(s)
      Hamai Y, Hihara J, Tanabe K, Furukawa T, Yamakita I, Ibuki Y, Okada M.
    • Journal Title

      Hiroshima J Med Sci

      Volume: 64 Pages: 27-30

    • NAID

      120005619821

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Results of Neoadjuvant Chemoradiotherapy With Docetaxel and 5-Fluorouracil Followed by Esophagectomy to Treat Locally Advanced Esophageal Cancer2015

    • Author(s)
      Hamai Y, Hihara J, Emi M, Murakami Y, Kenjo M, Nagata Y, Okada M
    • Journal Title

      Ann Thorac Surg

      Volume: in press Issue: 6 Pages: 1887-1893

    • DOI

      10.1016/j.athoracsur.2015.02.042

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Emergency escape surgery for a gastro-bronchial fistula with respiratory failure that developed after esophagectomy2015

    • Author(s)
      Ibuki Y, Hamai Y, Hihara J, Taomoto J, Kishimoto I, Miyata Y, Okada M
    • Journal Title

      Surg Today

      Volume: 45 Issue: 3 Pages: 369-373

    • DOI

      10.1007/s00595-013-0821-0

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effects of neoadjuvant chemoradiotherapy on postoperative morbidity and mortality associated with esophageal cancer2014

    • Author(s)
      Hamai Y, Hihara J, Taomoto J, Yamakita I, Ibuki Y, Okada M
    • Journal Title

      Dis Esophagus

      Volume: in press Issue: 4 Pages: 358-364

    • DOI

      10.1111/dote.12207

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Prospective randomized crossover study of effects of traditional Japanese herbal medicine rikkunshito on food intake and plasma acylated ghrelin levels in patients with esophageal cancer administered with cisplatin-based chemotherapy2017

    • Author(s)
      Yoichi Hamai, Tomoharu Yoshiya, Manabu Emi, Takaoki Furukawa, Yuta Ibuki, Morihito Okada
    • Organizer
      2017 Gastrointestinal cancers symposium
    • Place of Presentation
      San Francisco, USA
    • Year and Date
      2017-01-19
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Effects of neoadjuvant chemoradiotherapy on TNM staging and Its prognostic significance in esophageal squamous cell carcinoma2016

    • Author(s)
      Yoichi Hamai, Jun Hihara, Manabu Emi, Takaoki Furukawa, Ichiko Yamakita, Yuta Ibuki, Tomoaki Kurokawa, Morihito Okada
    • Organizer
      15th World Congress of the ISDE
    • Place of Presentation
      Singapore
    • Year and Date
      2016-09-19
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] 食道癌の術前化学放射線療法によるTNM stageの変化と予後の検討2016

    • Author(s)
      浜井洋一、檜原 淳、古川高意、山北伊知子、黒川智彰、岡田守人
    • Organizer
      第71回日本消化器外科学会総会
    • Place of Presentation
      徳島
    • Year and Date
      2016-07-14
    • Related Report
      2016 Research-status Report
  • [Presentation] 食道扁平上皮癌再発症例の治療成績と予後予測因子の検討2016

    • Author(s)
      浜井洋一、檜原 淳、古川高意、山北伊知子、黒川知彰、岡田守人
    • Organizer
      第70回日本食道学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2016-07-04
    • Related Report
      2016 Research-status Report
  • [Presentation] 食道癌における術前化学放射線療法後PETによるリンパ節転移と予後予測2016

    • Author(s)
      浜井洋一、檜原 淳、古川高意、山北伊知子、黒川智彰、岡田守人
    • Organizer
      第116回日本外科学会定期学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2016-04-14
    • Related Report
      2016 Research-status Report
  • [Presentation] Prediction of tumor response and survival by using 18F-fluorodeoxyglucose positron emission tomography in trimodality therapy for esophageal squamous cell carcinoma2015

    • Author(s)
      Yoichi Hamai, Jun Hihara, Takaoki Furukawa, Ichiko Yamakita, Tomoaki Kurokawa, Morihito Okada
    • Organizer
      European Cancer Congress 2015
    • Place of Presentation
      Vienna, Austria
    • Year and Date
      2015-09-25
    • Related Report
      2015 Research-status Report

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Published: 2015-04-16   Modified: 2019-03-29  

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