Research on personalized medicine against treatment-resistant liver cancer from the viewpoint of epithelial-Mesenchymal Transition and hierarchical replication ability

• Project/Area Number: 15K10162
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: Yamaguchi University
• Principal Investigator: NAGANO Hiroaki 山口大学, 大学院医学系研究科, 教授 (10294050)
• Co-Investigator(Kenkyū-buntansha): 和田 浩志 地方独立行政法人大阪府立病院機構大阪国際がんセンター(研究所), その他部局等, 消化器外科 副部長 (00572554) ; 浅岡 忠史 大阪大学, 医学部附属病院, 助教 (60528470) ; 江口 英利 大阪大学, 医学系研究科, 准教授 (90542118)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 肝細胞癌 / 治療抵抗性 / 形質転換 / 癌幹細胞 / 個別化治療

Outline of Final Research Achievements

Clinical specimens based on clinical experiences have been fully utilized as features of existing treatment resistant lesions, and the results were also examined together with in vitro retrieval results using hepatocellular carcinoma (HCC) cell lines.
The following involvements were confirmed; ① Epithelial mesenchymal transformation under hypoxic conditions against hepatocellular carcinoma, ② Cancer stem cell-like hierarchical replication ability of existing treatment resistant lesions. With respect to the characteristics of existing treatment resistant hepatocellular carcinoma, high expression of surface markers and miRNAs specific for cancer stem cells were involved. In addition, we demonstrated the possibility of development to a novel treatment method, by applying the reprogramming method of miRNA, regarding the characteristics of these HCC.

Research Products

• [Journal Article] MicroRNA-6826 and -6875 in plasma are valuable non invasive biomarkers that predict the efficacy of vaccine treatment against metastatic colorectal cancer (2017)
  • Author(s): 1.Kijima T, Hazama S, Tsunedomi R, Tanaka H, Takenouchi H, Kanekiyo S, Inoue Y, Nakashima M, Iida M, Sakamoto K, Suzuki N, Takeda S, Ueno T, Yamamoto S, Yoshino S, Okuno K, Nagano H
  • Journal Title: Oncol Rep Volume: 37(1) Pages: 23-30
  • Peer Reviewed / Open Access
• [Journal Article] Predictive biomarkers for the efficacy of peptide vaccine treatment: based on the results of a phase II study on advanced pancreatic cancer (2017)
  • Author(s): 2.Shindo Y, Hazama S, Suzuki N, Iguchi H, Uesugi K, Tanaka H, Aruga A, Hatori T, Ishizaki H, Umeda Y, Fujiwara T, Ikemoto T, Shimada M, Yoshimatsu K, Takenouchi H, Matsui H, Kanekiyo S, Iida M, Koki Y, Arima H, Furukawa H, Ueno T, Yoshino S, Fujita T, Kawakami Y, Nakamura Y, Oka M, Nagano H
  • Journal Title: J Exp Clin Cancer Res Volume: 36(1) Pages: 36-36
  • Peer Reviewed / Open Access
• [Journal Article] A phase ΙI clinical trial of peptide cocktail therapy for patients with advanced pancreatic cancer: VENUS-PC study (2017)
  • Author(s): 3.Suzuki N, Hazama S, Iguchi H, Uesugi K, Tanaka H, Hirakawa K, Aruga A, Hatori T, Ishizaki H, Umeda Y, Fujiwara T, Ikemoto T, Shimada M, Yoshimatsu K, Shimizu R, Hayashi H, Sakata K, Takenouchi H, Matsui H, Shindo Y, Iida M, Koki Y, Arima H, Furukawa H, Ueno T, Yoshino S, Nakamura Y, Oka M, Nagano H
  • Journal Title: Cancer Sci Volume: 108(1) Pages: 73-80
  • Peer Reviewed / Open Access
• [Journal Article] Cetuximab strongly enhances immune cell infiltration into liver metastatic sites in colorectal cancer (2017)
  • Author(s): 4.Inoue Y, Hazama S, Suzuki N, Tokumitsu Y, Kanekiyo S, Tomochika S, Tsunedomi R, Tokuhisa Y, Iida M, Sakamoto K, Takeda S, Ueno T, Yoshino S, Nagano H
  • Journal Title: Cancer Sci Volume: 108(3) Pages: 455-460
  • Peer Reviewed / Open Access
• [Journal Article] Rapid and sensitive detection of UGT1A1 polymorphisms associated with irinotecan toxicity by a novel DNA microarray (2017)
  • Author(s): 7.Tsunedomi R, Hazama S, Okayama N, Oka M, Nagano H
  • Journal Title: Cancer Sci Volume: 108(7) Pages: 1504-1509
  • Peer Reviewed / Open Access
• [Journal Article] miR-196b, miR-378a and miR-486 are predictive biomarkers for the efficacy of vaccine treatment in colorectal cancer (2017)
  • Author(s): 6.Shindo Y, Hazama S, Nakanmura Y, Inoue Y, Kanekiyo S, Suzuki N, Takenouchi H, Tsunedomi R, Nakajima M, Ueno T, Takeda S, Yoshino S, Okuno K, Fujita Y, Hamamoto Y, Kawakami Y, Oka M, Nagano H
  • Journal Title: Oncology Letters Volume: 14 Pages: 1355-1362
  • Peer Reviewed / Open Access
• [Journal Article] Highly sensitive stool DNA testing of Fusobacterium nucleatum as a marker for detection of colorectal tumours in a Japanese population (2017)
  • Author(s): 5.Suehiro Y, Sakai K, Nishioka M, Hashimoto S, Takami T, Higaki S, Shindo Y, Hazama S, Oka M, Nagano H, Sakaida I, Yamasaki T
  • Journal Title: Ann Clin Biochem Volume: 54(1) Pages: 86-91
  • Peer Reviewed / Open Access
• [Journal Article] Correlation Between NKG2DL Expression and Antitumor Effect of Protein-bound Polysaccharide-K in Tumor-bearing Mouse Models (2017)
  • Author(s): 8.Konagai A, Yoshimura K, Hazama S, Yamamoto N, Aoki K, Ueno T, Fujioka M, Iijima H, Kato M, Uchida M, Wada T, Inoue M, Asao T, Fuse M, Wada S, Kuramasu A, Kamei R, Takeda S, Yamamoto S, Yoshino S, Oka M, Nagano H
  • Journal Title: Anticancer Res Volume: 37(8) Pages: 4093-4101
  • Peer Reviewed / Open Access
• [Journal Article] Post-Operative Adjuvant Therapy for Resectable Pancreatic Cancer with Gemcitabine and Adoptive Immunotherapy. (2017)
  • Author(s): 9.Matsui H, Hazama S, Sakamoto K, Shindo Y, Kanekiyo S, Nakashima M, Matsukuma S, Tokuhisa Y, Iida M, Suzuki N, Yoshimura K, Takeda S, Ueno T, Yoshino S, Oka M, Nagano H
  • Journal Title: Pancreas Volume: 46(8) Pages: 994-1002
  • Peer Reviewed / Open Access
• [Journal Article] A practical approach to pancreatic cancer immunotherapy using resected tumor lysate vaccines processed to express α-gal epitopes (2017)
  • Author(s): 10.Furukawa K, Tanemura M, Miyoshi E, Eguchi H, Nagano H, Matsunami K, Nagaoka S, Yamada D, Asaoka T, Noda T, Wada H, Kawamoto K, Goto K, Taniyama K, Mori M, Doki Y
  • Journal Title: PLoS One Volume: 12(10)
  • Peer Reviewed / Open Access
• [Journal Article] miR-125b-1 and miR-378a are predictive biomarkers for the efficacy of vaccine treatment against colorectal cancer. (2017)
  • Author(s): 11.Tanaka H, Hazama S, Iida M, Tsunedomi R, Takenouchi H, Nakajima M, Tokumitsu Y, Kanekiyo S, Shindo Y, Tomochika S, Tokuhisa Y, Sakamoto K, Suzuki N, Takeda S, Yamamoto S, Yoshino S, Ueno T, Hamamoto Y, Fujita Y, Tanaka H, Tahara K, Shimizu R, Okuno K, Fujita K, Kuroda M, Nakamura Y, Nagano H
  • Journal Title: Cancer Sci Volume: 108(11) Pages: 2229-2238
  • Peer Reviewed / Open Access
• [Journal Article] A crucial epithelial to mesenchymal transition regulator, Sox4/Ezh2 axis is closely related to the clinical outcome in pancreatic cancer patients (2016)
  • Author(s): Hasegawa S, Nagano H, Konno M, Eguchi H, Tomokuni A, Tomimaru Y, Asaoka T, Wada H, Hama N, Kawamoto K, Marubashi S, Nishida N, Koseki J, Mori M, Doki Y, Ishii H
  • Journal Title: Int J Oncol Volume: 48(1) Pages: 145-152
  • Peer Reviewed / Open Access
• [Journal Article] Pre-treatment neutrophil to lymphocyte ratio as a predictive marker for pathological response to preoperative chemoradiotherapy in pancreatic cancer (2016)
  • Author(s): Hasegawa S, Eguchi H, Tomokuni A, Tomimaru Y, Asaoka T, Wada H, Hama N, Kawamoto K, Kobayashi S, Marubashi S, Konno M, Ishii H, Mori M, Doki Y, Nagano H
  • Journal Title: Oncology Letters Volume: 11(2) Pages: 1560-1566
  • Peer Reviewed / Open Access
• [Journal Article] Platelet count is more useful for predicting posthepatectomy liver failure at surgery for hepatocellular carcinoma than indocyanine green clearance test (2016)
  • Author(s): Tomimaru Y, Eguchi H, Gotoh K, Kawamoto K, Wada H, Asaoka T, Noda T, Yamada D, Ogawa H, Umeshita K, Nagano H, Doki Y, Mori M
  • Journal Title: J Surg Oncol Volume: 113(5) Pages: 565-569
  • Peer Reviewed / Open Access
• [Journal Article] The Clinical Impact of Transcatheter Arterial Chemoembolization (TACE)-Induced c-Met Upregulation on TACE Refractoriness in Hepatocellular Carcinoma (2016)
  • Author(s): Kajihara J, Tomimaru Y, Eguchi H, Yamada D, Wada H, Tomokuni A, Asaoka T, Kawamoto K, Marubashi S, Nagano H, Umeshita K, Doki Y, Mori M
  • Journal Title: Dig Dis Sci Volume: 61(6) Pages: 1572-1581
  • Peer Reviewed / Open Access
• [Journal Article] A Histone Deacetylase Inhibitor Suppresses Epithelial-Mesenchymal Transition and Attenuates Chemoresistance in Biliary Tract Cancer (2016)
  • Author(s): Sakamoto T, Kobayashi S, Yamada D, Nagano H, Tomokuni A, Tomimaru Y, Noda T, Gotoh K, Asaoka T, Wada H, Kawamoto K, Marubashi S, Eguchi H, Doki Y, Mori M
  • Journal Title: PLoS One Volume: 11(1)
  • Peer Reviewed / Open Access
• [Journal Article] Specific increase in serum core-fucosylated haptoglobin in patients with chronic pancreatitis (2016)
  • Author(s): Ueda M, Kamada Y, Takamatsu S, Shimomura M, Maekawa T, Sobajima T, Fujii H, Nakayama K, Nishino K, Yamada M, Kobayashi Y, Kumada T, Ito T, Eguchi H, Nagano H, Miyoshi E
  • Journal Title: Pancreatology Volume: 16(2) Pages: 238-243
  • Peer Reviewed / Open Access
• [Journal Article] Serum Mac-2 binding protein is a novel biomarker for chronic pancreatitis (2016)
  • Author(s): Maekawa T, Kamada Y, Ebisutani Y, Ueda M, Hata T, Kawamoto K, Takamatsu S, Mizutani K, Shimomura M, Sobajima T, Fujii H, Nakayama K, Nishino K, Yamada M, Kumada T, Ito T, Eguchi H, Nagano H, Miyoshi E
  • Journal Title: World J Gastroenterol Volume: 22(17) Pages: 4403-4410
  • Peer Reviewed / Open Access
• [Journal Article] Efficacy and Safety of Biweekly Docetaxel in Combination with Nedaplatin as Second-line Chemotherapy for Unresectable or Recurrent Esophageal Cancer (2016)
  • Author(s): Kanekiyo S, Takeda S, Nakajima M, Nishiyama M, Kitahara M, Shindou Y, Michihisa I, Abe T, Yoshino S, Hazama S, Nagano H
  • Journal Title: Anticancer Res Volume: 36(4) Pages: 1923-1927
  • Peer Reviewed / Open Access
• [Journal Article] Combined adjuvants of poly(I:C) plus LAG-3-Ig improve antitumor effects of tumor-specific T cells, preventing their exhaustion (2016)
  • Author(s): Kano Y, Iguchi T, Matsui H, Adachi K, Sakoda Y, Miyakawa T, Doi S, Hazama S, Nagano H, Ueyama Y, Tamada K
  • Journal Title: Cancer Sci Volume: 107(4) Pages: 398-406
  • Peer Reviewed / Open Access
• [Journal Article] Selection criteria for hepatic resection in intermediate-stage (BCLC stage B) multiple hepatocellular carcinoma (2016)
  • Author(s): Wada H, Eguchi H, Noda T, Ogawa H, Yamada D, Tomimaru Y, Tomokuni A, Asaoka T, Kawamoto K, Gotoh K, Marubashi S, Umeshita K, Nagano H, Doki Y, Mori M
  • Journal Title: Surgery Volume: 160(5) Pages: 1227-1235
  • Peer Reviewed / Open Access
• [Journal Article] Serum Metabolite Profiling for the Detection of Pancreatic Cancer: Results of a Large Independent Validation Study (2016)
  • Author(s): Akita H, Ritchie SA, Takemasa I, Eguchi H, Pastural E, Jin W, Yamazaki Y, Goodenowe DB, Nagano H, Monden M, Mori M, Doki Y
  • Journal Title: Pancreas Volume: 45(10) Pages: 1418-1423
  • Peer Reviewed / Open Access
• [Journal Article] Calreticulin is highly expressed in pancreatic cancer stem-like cells (2016)
  • Author(s): Matsukuma S, Yoshimura K, Ueno T, Oga A, Inoue M, Watanabe Y, Kuramasu A, Fuse M, Tsunedomi R, Nagaoka S, Eguchi H, Matsui H, Shindo Y, Maeda N, Tokuhisa Y, Kawano R, Furuya-Kondo T, Itoh H, Yoshino S, Hazama S, Oka M, Nagano H
  • Journal Title: Cancer Sci Volume: 107(11) Pages: 1599-1609
  • Peer Reviewed / Open Access
• [Journal Article] Rubicon inhibits autophagy and accelerates hepatocyte apoptosis and lipid accumulation in nonalcoholic fatty liver disease (2016)
  • Author(s): Tanaka S, Hikita H, Tatsumi T, Sakamori R, Nozaki Y, Sakane S, Shiode Y, Nakabori T, Saito Y, Hiramatsu N, Tabata K, Kawabata T, Hamasaki M, Eguchi H, Nagano H, Yoshimori T, Takehara T
  • Journal Title: Hepatology Volume: 64(6) Pages: 1994-2014
  • Peer Reviewed / Open Access
• [Journal Article] Outcomes of Living Donor Liver Transplantation Alone for Patients on Maintenance Renal Replacement Therapy in Japan: Results of a Nationwide Survey (2016)
  • Author(s): Eguchi S, Furukawa H, Uemoto S, Umeshita K, Imamura H, Soyama A, Shimamura T, Isaji S, Ogura Y, Egawa H, Kawachi S, Kasahara M, Nagano H, Ku Y, Ohdan H, Maehara Y, Sato S, Inomata Y
  • Journal Title: Transplant Direct Volume: 2(6)
  • Peer Reviewed / Open Access
• [Journal Article] Prediction of the efficacy of immunotherapy by measuring the integrity of cell-free DNA in plasma in colorectal cancer (2016)
  • Author(s): Kitahara M, Hazama S, Tsunedomi R, Takenouchi H, Kanekiyo S, Inoue Y, Nakajima M, Tomochika S, Tokuhisa Y, Iida M, Sakamoto K, Suzuki N, Takeda S, Ueno T, Yamamoto S, Yoshino S, Nagano H
  • Journal Title: Cancer Sci Volume: 107(12) Pages: 1825-1829
  • Peer Reviewed / Open Access
• [Journal Article] Increased FGF19 copy number is frequently detected in hepatocellular carcinoma with a complete response after sorafenib treatment (2016)
  • Author(s): Kaibori M, Sakai K, Ishizaki M, Matsushima H, De Velasco MA, Matsui K, Iida H, Kitade H, Kwon AH, Nagano H, Wada H, Haji S, Tsukamoto T, Kanazawa A, Takeda Y, Takemura S, Kubo S, Nishio K
  • Journal Title: Oncotarget Volume: 7(31) Pages: 49091-49098
  • NAID: 40021426106
  • Peer Reviewed / Open Access
• [Journal Article] Simeprevir or telaprevir with peginterferon and ribavirin for recurrent hepatitis C after living donor liver transplantation: A Japanese multicenter experience (2016)
  • Author(s): Ueda Y, Ikegami T, Soyama A, Akamatsu N, Shinoda M, Ishiyama K, Honda M, Marubashi S, Okajima H, Yoshizumi T, Eguchi S, Kokudo N, Kitagawa Y, Ohdan H, Inomata Y, Nagano H, Shirabe K, Uemoto S, Maehara Y
  • Journal Title: Hepatol Res Volume: 46(13) Pages: 1285-1293
  • Peer Reviewed / Open Access
• [Journal Article] Poorly differentiated hepatocellular carcinoma accompanied by anti-Hu antibody-positive paraneoplastic peripheral neuropathy (2015)
  • Author(s): Matsui T, Hori Y, Nagano H, Eguchi H, Marubashi S, Wada H, Wada N, Ikeda JI, Sakamoto M, Morii E
  • Journal Title: Pathol Int Volume: 65(7) Pages: 388-392
  • Peer Reviewed / Open Access
• [Journal Article] Clinical significance of surgical resection of metastatic lymph nodes from hepatocellular carcinoma (2015)
  • Author(s): Tomimaru Y, Wada H, Eguchi H, Tomokuni A, Hama N, Kawamoto K, Marubashi S, Umeshita K, Doki Y, Mori M, Wakasa K, Nagano H
  • Journal Title: Surg Today Volume: 45(9) Pages: 1112-1120
  • Peer Reviewed / Open Access
• [Journal Article] miR-615-3p expression level in bone marrow is associated with tumor recurrence in hepatocellular carcinoma (2015)
  • Author(s): Mukai R, Tomimaru Y, Nagano H, Eguchi H, Mimori K, Tomokuni A, Asaoka T, Wada H, Kawamoto K, Marubashi S, Doki Y, Mori M
  • Journal Title: Mol Clin Oncol Volume: 3(3) Pages: 563-571
  • Peer Reviewed / Open Access
• [Journal Article] Quantitative Imaging: Quantification of Liver Shape on CT Using the Statistical Shape Model to Evaluate Hepatic Fibrosis. (2015)
  • Author(s): Hori M, Okada T, Higashiura K, Sato Y, Chen YW, Kim T, Onishi H, Eguchi H, Nagano H, Umeshita K, Wakasa K, Tomiyama N
  • Journal Title: Acad Radiol Volume: 22(3) Pages: 303-309
  • Peer Reviewed / Open Access
• [Journal Article] Do patients with small solitary hepatocellular carcinomas without macroscopically vascular invasion require anatomic resection? Propensity score analysis. (2015)
  • Author(s): Hirokawa F, Kubo S, Nagano H, Nakai T, Kaibori M, Hayashi M, Takemura S, Wada H, Nakata Y, Matsui K, Ishizaki M, Uchiyama K.
  • Journal Title: Surgery Volume: 157(1) Pages: 27-36
  • Peer Reviewed / Open Access
• [Journal Article] Combination therapy with S-1 and interferon-α in hepatocellular carcinoma patients with lung metastasis. (2015)
  • Author(s): Akita H, Marubashi S, Wada H, Hama N, Kawamoto K, Kobayashi S, Eguchi H, Doki Y, Mori M, Nagano H.
  • Journal Title: Mol Clin Oncol. Volume: 3(2) Pages: 322-328
  • Peer Reviewed / Open Access
• [Presentation] A phase i study of novel multi-HLA-binding peptides and a new combination of immune adjuvants against solid tumors (2017)
  • Author(s): 1.Matsui H, Hazama S, Tamada K, Udaka K, Koki Y, Uematsu T, Arima H, Furukawa H, Miyakawa T, Doi S, Kitahara M, Kanekiyo S, Tokumitsu Y, Tokuhisa Y, Sakamoto K, Suzuki N, Takeda S, Yamamoto S, Yoshino S, Nagano H
  • Organizer: 2017 ASCO Annual Meeting
  • Int'l Joint Research
• [Presentation] 胃癌患者における腫瘍周囲間質のSPARC 高発現は予後良好因子である (2017)
  • Author(s): 2.中島正夫、吉野茂文、飯田通久、兼清信介、前田訓子、西山光郎、北原正博、徳光幸生、友近忍、徳久善弘、坂本和彦、鈴木伸明、武田茂、山本滋、硲彰一、上野富雄、永野浩昭
  • Organizer: 第117回日本外科学会定期学術集会
• [Presentation] 肝細胞癌幹細胞様Sphere細胞における抗癌剤耐性に関わる遺伝子の同定 (2017)
  • Author(s): 3.恒富亮一、吉村清、松隈聰、兼清信介、飯田通久、鈴木伸明、武田茂、吉野茂文、硲彰一、上野富雄、永野浩昭
  • Organizer: 第76回日本癌学会学術総会
• [Presentation] 膵癌幹細胞様細胞に高発現した分子の同定と解析 (2017)
  • Author(s): 4.松隈聰、吉村清、坂本和彦、小賀厚徳、恒富亮一、布施雅規、鈴木伸明、武田茂、吉野茂文、硲彰一、江口英利、上野富雄、永野浩昭
  • Organizer: 第76回日本癌学会学術総会
• [Presentation] 癌幹細胞様細胞における抗癌剤耐性に影響を及ぼす遺伝子の同定 (2017)
  • Author(s): 恒富亮一、吉村清、松隈聰、兼清信介、友近忍、徳久善弘、飯田通久、坂本和彦、鈴木伸明、武田茂、山本滋、吉野茂文、硲彰一、上野富雄、永野浩昭
  • Organizer: 第55回日本癌治療学会学術集会
• [Presentation] 少数例におけるネオアンチゲン探索の経験（由来エピトープペプチドに対する新規免疫療法の開発） (2017)
  • Author(s): 6.兼清信介、硲彰一、恒富亮一、松井洋人、鈴木伸明、中島正夫、田中宏典、徳光幸生、友近忍、徳久善弘、飯田通久、坂本和彦、武田茂、山本滋、吉野茂文、上野富雄、玉田耕治、永野浩昭
  • Organizer: 第30回日本バイオセラピィ学会学術集会総会
• [Presentation] 負の免疫病態（免疫チェックポイント）を制御する 新規アジュバントを用いたがんペプチド療法の開発 (2017)
  • Author(s): 7.鈴木伸明、硲彰一、中島正夫、北原正博、松井洋人、兼清信介、徳光幸生、友近忍、徳久善弘、飯田通久、坂本和彦、武田茂、山本滋、吉野茂文、玉田耕治、上野富雄、永野浩昭
  • Organizer: 第30回日本バイオセラピィ学会学術集会総会
• [Presentation] 肝細胞癌（HCC）に対する術後補助療法としてのHSP70-mRNA導入樹状細胞療法第I/II相試験（中間報告） (2017)
  • Author(s): 8.松井洋人、硲彰一、中島正夫、松隈聰、兼清信介、徳光幸生、新藤芳太郎、恒富亮一、友近忍、飯田通久、徳久善弘、坂本和彦、鈴木伸明、武田茂、吉野茂文、玉田耕治、上野富雄、永野浩昭
  • Organizer: 第30回日本バイオセラピィ学会学術集会総会
• [Presentation] 肝細胞癌幹細胞様Sphere細胞における転移能亢進及びCD44 アイソフォーム発現 (2016)
  • Author(s): 恒富亮一、永野浩昭、他
  • Organizer: 第75回日本癌学会学術総会
  • Place of Presentation: 神奈川県横浜市（パシフィコ横浜）
  • Year and Date: 2016-10-06
• [Presentation] Calreticulinは膵癌幹細胞様細胞に高発現し膵癌患者の予後不良因子である (2016)
  • Author(s): 松隈聰、永野浩昭、他
  • Organizer: 第75回日本癌学会学術総会
  • Place of Presentation: 神奈川県横浜市（パシフィコ横浜）
  • Year and Date: 2016-10-06
• [Presentation] 肝転移能亢進を示す癌幹細胞様細胞におけるCD44 isoformsの発現 (2016)
  • Author(s): 恒富亮一、永野浩昭、他
  • Organizer: 第27回日本消化器癌発生学会総会
  • Place of Presentation: 鹿児島県鹿児島市（城山観光ホテル）
  • Year and Date: 2016-09-15
• [Presentation] 膵癌幹細胞様細胞に高発現する分子の同定と同分子の臨床的意義に関する検討 (2016)
  • Author(s): 松隈聰、永野浩昭、他
  • Organizer: 第27回日本消化器癌発生学会総会
  • Place of Presentation: 鹿児島県鹿児島市（城山観光ホテル）
  • Year and Date: 2016-09-15
• [Presentation] 門脈内腫瘍栓をともなう進行肝細胞癌における上皮間葉移行（EMT）関連転写因子と癌幹細胞マーカーの発現解析 (2015)
  • Author(s): 日向 聖、永野浩昭、他
  • Organizer: 第51回日本肝臓学会総会
  • Place of Presentation: 熊本県熊本市（ホテル日航熊本他）
  • Year and Date: 2015-05-21
• [Presentation] 肝細胞癌臨床検体における癌幹細胞マーカーCD13の発現とE-Cadherin、Vimentinの発現解析 (2015)
  • Author(s): 山中千尋、永野浩昭、他
  • Organizer: 第51回日本肝臓学会総会
  • Place of Presentation: 熊本県熊本市（ホテル日航熊本他）
  • Year and Date: 2015-05-21
• [Presentation] c-MET発現解析にもとずく肝細胞癌における肝動脈化学塞栓療法不応の機序解明について (2015)
  • Author(s): 梶原 淳、永野浩昭、他
  • Organizer: 第51回日本肝臓学会総会
  • Place of Presentation: 熊本県熊本市（ホテル日航熊本他）
  • Year and Date: 2015-05-21
• [Presentation] 高度脈管侵襲をともなう肝細胞癌に対する肝切除／IFN併用化学療法を基軸とした治療戦略 (2015)
  • Author(s): 和田浩志、永野浩昭、他
  • Organizer: 第115回日本外科学会定期学術集会
  • Place of Presentation: 愛知県名古屋市（名古屋国際会議場）
  • Year and Date: 2015-04-16
• [Presentation] 肝細胞癌に対するCD13阻害剤を用いた併用療法による抗腫瘍効果および作用機序に関する基礎的検討 (2015)
  • Author(s): 山下雅史、永野浩昭、他
  • Organizer: 第115回日本外科学会定期学術集会
  • Place of Presentation: 愛知県名古屋市（名古屋国際会議場）
  • Year and Date: 2015-04-16