Elucidation of molecular mechanism in liver metastasis of gastroenteropancreatic neuroendocrine tumors

Research Project

Project/Area Number	15K10179
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Digestive surgery
Research Institution	Tohoku University
Principal Investigator	Mizuma Masamichi 東北大学, 大学病院, 助教 (80578675)
Co-Investigator(Renkei-kenkyūsha)	TACHIKAWA Masanori 東北大学, 薬学研究科(研究院), 准教授 (00401810)
Research Collaborator	TAKADATE Tatsuyuki ISEKI Masahiro HATA Tatsuo AOKI Shuichi SHIMURA Mitsuhiro KATOH Yasutake SUZUKI Takashi
Project Period (FY)	2015-04-01 – 2018-03-31
Project Status	Completed (Fiscal Year 2017)
Budget Amount *help	¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000) Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000) Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000) Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords	神経内分泌腫瘍 / 肝転移 / CNPY2 / 膵神経内分泌腫瘍 / 膵臓 / 転移
Outline of Final Research Achievements	The aim of this study was to identify novel liver metastasis-correlated proteins of pancreatic neuroendocrine neoplasm (PanNEN). Proteomic analysis was performed in resected specimens of pancreatic tumor and paired liver metastasis. ANXA6, CNPY2, RAB11B, and TUBB3, which showed higher expression in liver metastasis than in pancreatic tumor, were selected as candidate proteins. Expression of these candidate proteins was examined in pancreatic tumors of 70 patients with PanNEN by immunohistochemistry. Correlation between clinicopathological factors and expression of the candidate proteins was statistically analyzed. It was revealed that CNPY2 is a novel liver metastasis correlated protein of PanNEN.