Development of diagnostic biomarker for cholangiocarcinoma by analysis of miRNA in exosome of bile

• Project/Area Number: 15K10194
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: Osaka City University
• Principal Investigator: TAKEMURA Shigekazu 大阪市立大学, 大学院医学研究科, 講師 (00322363)
• Co-Investigator(Kenkyū-buntansha): 南山 幸子 京都府立大学, 生命環境科学研究科, 教授 (00362989) ; 久保 正二 大阪市立大学, 大学院医学研究科, 准教授 (80221224)
• Co-Investigator(Renkei-kenkyūsha): FUJIWARA Toshinobu 近畿大学, 薬学部・医療薬学科, 教授 (80362804)
• Research Collaborator: NAKGAWA Kanako ; TAKAHATA Nozomi
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 胆道癌 / 胆汁 / バイオマーカー / 印刷業

Outline of Final Research Achievements

We examined redox dynamics, bile acid composition and mutagenicity of bile obtained from biliary tract cancer patients. Furthermore, miRNAs contained in exosomes purified from bile were analyzed. Bile obtained from biliary tract cancer patients contained significantly more oxidized glutathione. Bile acids in the bile of patients with biliary tract cancer were found to contain a lot of secondary bile acids. The mutagenicity by the umu method was negative for all tested bile. Exosomes in the bile could not be stably collected by the known methods. We have developed a novel method to reproducibly extract exosomes from bile. Candidate miRNAs specific for biliary tract cancer were identified.

Research Products

• [Journal Article] Stagnation of histopathological improvement is a predictor of hepatocellular carcinoma development after hepatitis C virus eradication. (2018)
  • Author(s): Motoyama H, Tamori A, Kubo S, Uchida-Kobayashi S, Takemura S, Tanaka S, Ohfuji S, Teranishi Y, Kozuka R, Kawamura E, Hagihara A, Morikawa H, Enomoto M, Murakami Y, Kawada N.
  • Journal Title: PLoS One. Volume: 13 Issue: 3 Pages: 0194163-0194163
  • DOI: 10.1371/journal.pone.0194163
  • NAID: 120006411697
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] A phase I study for adjuvant chemotherapy of gemcitabine plus S-1 in patients with biliary tract cancer undergoing curative resection without major hepatectomy (KHBO1202) (2018)
  • Author(s): Yanagimoto Hiroaki、Toyokawa Hideyoshi、Sakai Daisuke、Wada Hiroshi、Satoi Sohei、Yamamoto Tomohisa、Nagano Hiroaki、Toyoda Masanori、Ajiki Tetsuo、Satake Hironaga、Tsuji Akihito、Miyamoto Atsushi、Tsujie Masanori、Takemura Shigekazu、Yanagihara Kazuhiro、Ioka Tatsuya
  • Journal Title: Cancer Chemotherapy and Pharmacology Volume: 81 Issue: 3 Pages: 461-468
  • DOI: 10.1007/s00280-017-3513-4
  • Peer Reviewed
• [Journal Article] Occupational cholangiocarcinoma caused by exposure to 1,2-dichloropropane and/or dichloromethane (2018)
  • Author(s): S. Kubo, S. Takemura, S. Tanaka, H. Shinkawa, M. Kinoshita, G. Hamano, T. Ito, M. Koda, T. Aota
  • Journal Title: Annals of Gastroenterological Surgery Volume: 印刷中 Issue: 2 Pages: 99-105
  • DOI: 10.1002/ags3.12051
  • Peer Reviewed
• [Journal Article] MR imaging and MR cholangiopancreatography of cholangiocarcinoma developing in printing company workers. (2017)
  • Author(s): Koyama K, Kubo S, Ueki A, Shimono T, Takemura S, Tanaka S, Kinoshita M, Hamano G, Miki Y.
  • Journal Title: Jpn J Radiol. Volume: 印刷中 Issue: 5 Pages: 233-241
  • DOI: 10.1007/s11604-017-0626-y
  • NAID: 50012595356
  • Peer Reviewed / Open Access
• [Journal Article] Attenuation of Bleomycin-Induced Pulmonary Fibrosis in Rats with S-Allyl Cysteine (2017)
  • Author(s): Tsukioka Takuma、Takemura Shigekazu、Minamiyama Yukiko、Mizuguchi Shinjiro、Toda Michihito、Okada Shigeru
  • Journal Title: Molecules Volume: 22 Issue: 4 Pages: 543-543
  • DOI: 10.3390/molecules22040543
  • Peer Reviewed / Open Access
• [Journal Article] Portal Vein Embolization: History and Current Indications (2017)
  • Author(s): Shinkawa Hiroji、Takemura Shigekazu、Tanaka Shogo、Kubo Shoji
  • Journal Title: Visceral Medicine Volume: 33 Issue: 6 Pages: 414-417
  • DOI: 10.1159/000479474
  • Peer Reviewed
• [Journal Article] S-allyl-glutathione improves experimental liver fibrosis by regulating Kupffer cell activation in rats. (2017)
  • Author(s): Takemura S, Azuma H, Osada-Oka M, Kubo S, Shibata T, Minamiyama Y.
  • Journal Title: Am J Physiol Gastrointest Liver Physiol. Volume: 314(2) Issue: 2 Pages: G150-G163
  • DOI: 10.1152/ajpgi.00023.2017
  • Peer Reviewed / Open Access
• [Journal Article] Carbon monoxide-releasing molecule, CORM-3, modulates alveolar macrophage M1/M2 phenotype in vitro (2017)
  • Author(s): Yamamoto-Oka Hiroko、Mizuguchi Shinjiro、Toda Michihito、Minamiyama Yukiko、Takemura Shigekazu、Shibata Toshihiko、Cepinskas Gediminas、Nishiyama Noritoshi
  • Journal Title: Inflammopharmacology Volume: 26 Issue: 2 Pages: 435-445
  • DOI: 10.1007/s10787-017-0371-y
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Perioperative allogenic blood transfusion is a poor prognostic factor after hepatocellular carcinoma surgery: a multi-center analysis (2017)
  • Author(s): Wada Hiroshi、Eguchi Hidetoshi、Nagano Hiroaki、Kubo Shoji、Nakai Takuya、Kaibori Masaki、Hayashi Michihiro、Takemura Shigekazu、Tanaka Shogo、Nakata Yasuyuki、Matsui Kosuke、Ishizaki Morihiko、Hirokawa Fumitoshi、Komeda Koji、Uchiyama Kazuhisa、Kon Masanori、Doki Yuichiro、Mori Masaki
  • Journal Title: Surgery Today Volume: 48 Issue: 1 Pages: 73-79
  • DOI: 10.1007/s00595-017-1553-3
  • Peer Reviewed
• [Journal Article] The PD-1/PD-L1 may be aberrantly activated in occupational cholangiocarcinoma (2016)
  • Author(s): Sato Y, Kinoshita M, Takemura S, Tanaka S, Hamano G, Nakamori S, Fujikawa M, Sugawara Y, Yamamoto T, Arimoto A, Yamamura M, Sasaki M, Harada K, Nakanuma Y, Kubo S
  • Journal Title: Pathology International Volume: 67 Issue: 3 Pages: 163-170
  • DOI: 10.1111/pin.12511
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Questionnaire survey on work motivations of gastrointestinal and hepatobiliary pancreatic surgeons enrolled in a Japanese national interdisciplinary program. (2016)
  • Author(s): Kaibori M, Nitta H, Hayashi M, Takemura S, Nagano H, Matsui K, Ikoma H, Nakai T, Yasunaga M, Kido M, Aoki T, Rikiyama T, Sano K, Kudo A, Katagiri S, Otsuka Y, Kuroki T, Nomi T, Yano K, Endo I, Ueno M, Kanazawa A, et al.
  • Journal Title: J Hepatobiliary Pancreat Sci. Volume: 23 Issue: 11 Pages: 697-702
  • DOI: 10.1002/jhbp.392
  • Peer Reviewed
• [Journal Article] Increased FGF19 copy number is frequently detected in hepatocellular carcinoma with a complete response after sorafenib treatment. (2016)
  • Author(s): Kaibori M, Sakai K, Ishizaki M, Matsushima H, De Velasco MA, Matsui K, Iida H, Kitade H, Kwon AH, Nagano H, Wada H, Haji S, Tsukamoto T, Kanazawa A, Takeda Y, Takemura S, Kubo S, Nishio K.
  • Journal Title: Oncotarget Volume: 23 Issue: 31 Pages: 49091-49098
  • DOI: 10.18632/oncotarget.10077
  • NAID: 40021426106
  • Peer Reviewed
• [Journal Article] Outcomes after resection of occupational cholangiocarcinoma (2016)
  • Author(s): Kubo S, Takemura S, Tanaka S, Shinkawa H, Kinoshita M, Hamano G, et al.
  • Journal Title: Journal of Hepato-Biliary Pancreatic Sciences Volume: 23 Issue: 9 Pages: 556-564
  • DOI: 10.1002/jhbp.373
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Hypermutation and unique mutational signatures of occupational cholangiocarcinoma in printing workers exposed to haloalkanes. (2016)
  • Author(s): Mimaki S, Totsuka Y, Suzuki Y, Nakai C, Goto M, Kojima M, Arakawa H, Takemura S, Tanaka S, Marubashi S, Kinoshita M, Matsuda T, Shibata T, Nakagama H, Ochiai A, Kubo S, Nakamori S, Esumi H, Tsuchihara K.
  • Journal Title: Carcinogenesis Volume: 37 Issue: 8 Pages: 817-826
  • DOI: 10.1093/carcin/bgw066
  • Peer Reviewed / Open Access
• [Journal Article] Comparison of clinicopathological characteristics between patients with occupational and non-occupational intrahepatic cholangiocarcinoma. (2016)
  • Author(s): Hamano G, Kubo S, Takemura S, Tanaka S, Shinkawa H, Kinoshita M, Ito T, Yamamoto T, Wakasa K, Shibata T.
  • Journal Title: J Hepatobiliary Pancreat Sci. Volume: 23 Issue: 7 Pages: 389-396
  • DOI: 10.1002/jhbp.353
  • Peer Reviewed
• [Journal Article] The association between non-alcoholic steatohepatitis and intrahepatic cholangiocarcinoma: A hospital based case-control study. (2016)
  • Author(s): Kinoshita M, Kubo S, Tanaka S, Takemura S, Nishioka T, Hamano G, Ito T, Tanaka S, Ohsawa M, Shibata T.
  • Journal Title: J Surg Oncol. Volume: 113 Issue: 7 Pages: 779-783
  • DOI: 10.1002/jso.24223
  • Peer Reviewed
• [Journal Article] Pathological spectrum of bile duct lesions from chronic bile duct injury to invasive cholangiocarcinoma corresponding to bile duct imaging findings of occupational cholangiocarcinoma. (2016)
  • Author(s): Kinoshita M, Kubo S, Nakanuma Y, Sato Y, Takemura S, Tanaka S, Hamano G, Ito T, Terajima H, Yamada T, Nakamori S, Arimoto A, Fujikawa M, Sugawara Y, Yamamoto T, Abue M, Nakagawa K, Unno M, Mizuguchi T, Takenaka K, Shirabe K, Shibata T.
  • Journal Title: J Hepatobiliary Pancreat Sci. Volume: 23 Pages: 92-101
  • Peer Reviewed
• [Journal Article] Outcomes of laparoscopic hepatic resection versus percutaneous radiofrequency ablation for hepatocellular carcinoma located at the liver surface: A case-control study with propensity score matching. (2016)
  • Author(s): Ito T, Tanaka S, Iwai S, Takemura S, Hagihara A, Uchida-Kobayashi S, Shinkawa H, Nishioka T, Kawada N, Kubo S.
  • Journal Title: Hepatol Res. Volume: 46 Issue: 6 Pages: 565-574
  • DOI: 10.1111/hepr.12592
  • Peer Reviewed
• [Journal Article] Screening and surveillance for occupational cholangiocarcinoma in workers exposed to organic solvents. (2016)
  • Author(s): Kubo S, Takemura S, Tanaka S, Nishioka T, Kinoshita M, Hamano G, Ito T, Yamamoto T, Abue M, Aoki M, Nakagawa K, Hijioka S, Miyamoto A, Osaki Y, Endo G, Kumagai S.
  • Journal Title: Surg Today Volume: 46 Issue: 6 Pages: 705-712
  • DOI: 10.1007/s00595-015-1229-9
  • NAID: 120006586208
  • Peer Reviewed / Open Access
• [Journal Article] MicroRNA expression in hepatocellular carcinoma after the eradication of chronic hepatitis virus C infection using interferon therapy (2016)
  • Author(s): Tamori, A
  • Journal Title: Hepatology Res Volume: 46 Issue: 3 Pages: 26-35
  • DOI: 10.1111/hepr.12518
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] 新しい職業がんの発症とその予防 職業性胆管癌の臨床的特徴 (2016)
  • Author(s): 久保 正二(大阪市立大学 大学院肝胆膵外科学), 竹村 茂一, 田中 肖吾, 新川 寛二, 西岡 孝芳, 木下 正彦, 濱野 玄弥, 伊藤 得路, 中沼 安二, 圓藤 吟史
  • Journal Title: 日本職業・災害医学会会誌 Volume: 64 Pages: 1-5
  • Peer Reviewed
• [Journal Article] 【肝内胆管癌の新しい規約と治療戦略】 肝内胆管癌の疫学的動向と危険因子 (2016)
  • Author(s): 久保 正二, 竹村 茂一, 田中 肖吾, 新川 寛二, 木下 正彦, 濱野 玄弥, 伊藤 得路, 青田 尚哲, 江田 将樹, 上西 崇弘
  • Journal Title: 外科 Volume: 78 Pages: 115-121
  • Peer Reviewed
• [Journal Article] Therapeutic administration of an ingredient of aged-garlic extracts, <i>S</i>-allyl cysteine resolves liver fibrosis established by carbon tetrachloride in rats (2015)
  • Author(s): Kodai S,Takemura S, Kubo S, Azuma H, Minamiya Y
  • Journal Title: Journal of Clinical Biochemistry and Nutrition Volume: 56 Issue: 3 Pages: 179-185
  • DOI: 10.3164/jcbn.14-108
  • NAID: 130005068184
  • ISSN: 0912-0009, 1880-5086
  • Peer Reviewed / Open Access
• [Journal Article] Management of hepatitis B virus infection during treatment for hepatitis B virus-related hepatocellular carcinoma. (2015)
  • Author(s): Kubo S, Takemura S, Tanaka S, Shinkawa H, Nishioka T, Nozawa A, Kinoshita M, Hamano G, Ito T, Urata Y
  • Journal Title: World Journal of Gastroenterology Volume: 21 Issue: 27 Pages: 8249-8255
  • DOI: 10.3748/wjg.v21.i27.8249
  • Peer Reviewed
• [Journal Article] Cytoglobin Deficiency Promotes Liver Cancer Development from Hepatosteatosis through Activation of the Oxidative Stress Pathway. (2015)
  • Author(s): Thuy le TT, Matsumoto Y, Thuy TT, Hai H, Suoh M, Urahara Y, Motoyama H, Fujii H, Tamori A, Kubo S, Takemura S, Morita T, Yoshizato K, Kawada N
  • Journal Title: The American Journal of Pathology Volume: 185 Issue: 4 Pages: 1045-1060
  • DOI: 10.1016/j.ajpath.2014.12.017
  • Peer Reviewed
• [Journal Article] Do patients with small solitary hepatocellular carcinomas without macroscopically vascular invasion require anatomic resection? Propensity score analysis (2015)
  • Author(s): Hirokawa F, Kubo S, Nagano H, Nakai T, Kaibori M, Hayashi M, Takemura S, Wada H, Nakata Y, Matsui K, Ishizaki M, Uchiyama K.
  • Journal Title: Surgery Volume: 157 Issue: 1 Pages: 27-36
  • DOI: 10.1016/j.surg.2014.06.080
  • Peer Reviewed
• [Journal Article] 印刷会社で集団発生した胆管癌の最近の知見 Ⅱ 職業性胆管癌症例の臨床的特徴 (2015)
  • Author(s): 久保正二，竹村茂一，田中肖吾，木下正彦，濱野玄弥，伊藤得路，青田尚哲，江田将樹，中沼安二，圓藤吟史
  • Journal Title: 産業医学レビュー Volume: 28 Pages: 139-146
  • Peer Reviewed
• [Journal Article] 職業性胆管癌の病態とその特徴 (2015)
  • Author(s): 久保正二，竹村茂一，田中肖吾，新川寛二，木下正彦，濱野玄弥，伊藤得路，青田尚哲，江田将樹，佐藤保則，中沼安二
  • Journal Title: 肝胆膵 Volume: 71 Pages: 877-885
  • Peer Reviewed
• [Presentation] Development of cholangiocarcinoma in a printing company employee: Occupational cholangiocarcinoma (2017)
  • Author(s): S. Kubo, S. takemura, S. Tanaka, G. Hamano, M. Kinoshita, T. Ito, Y. Kurashima, M. Koda
  • Organizer: The 6th Biennial Congress of the Asia-Pacific Hepato-Pancreato-Biliary Association
  • Int'l Joint Research / Invited
• [Presentation] 化学物質大量暴露を伴う職業性胆管がんの遺伝子変異の特異性 (2017)
  • Author(s): 三牧幸代、渡辺正彦、久保正二、上原一哉
  • Organizer: 第76回日本癌学会学術総会
• [Presentation] The clinical significance of the serum concentration of duke pancreatic monoclonal antigen type 2 (DUPAN-2) in biliary tract cancer (2017)
  • Author(s): Ito T, Tanaka S, Takemura S, Hamano G, Kurashima Y, Koda M, Aota T, Kubo S
  • Organizer: The 4th Kansai-Yeungnam
  • Int'l Joint Research
• [Presentation] Is lymph node dissection necessary for small (2017)
  • Author(s): Hamano G, Takemura S, Tanaka S, Ito T, Kurashima Y, Aota T, Koda M, Kubo S
  • Organizer: The 29th Meeting of Japanese Society of Hepato-Biliary-Pancreatic Surgery
• [Presentation] The significance of the serum concentration of duke pancreatic monoclonal antigen type 2 (2017)
  • Author(s): Ito T, Tanaka S, Takemura S, Hamano G, Kurashima Y, Koda M, Aota T, Kubo S
  • Organizer: The 29th Meeting of Japanese Society of Hepato-Biliary-Pancreatic Surgery
• [Presentation] The clinical significance of the serum concentration of duke pancreatic monoclonal antigen type 2 (DUPAN-2) in biliary tract cancer (2017)
  • Author(s): Ito T, Tanaka S, Takemura S, Hamano G, Kurashima Y, Aota T, Koda M, Kubo S
  • Organizer: American College of Surgeons (ACS) Clinical Congress 2017
  • Int'l Joint Research
• [Presentation] S-allyl-glutathione improves liver fibrosis by inhibition of excess M1- or M2- polarized macrophage in rats (2017)
  • Author(s): Takemura S, Minamiyama Y, Azuma H, Osada-Oka M, Kubo S
  • Organizer: The 68th Annual Meeting of the American Association for the Study of Liver Diseases (AASLD)
  • Int'l Joint Research
• [Presentation] Development of cholangiocarcinoma in a printing company employee: Occupational cholangiocarcinoma (2016)
  • Author(s): Kubo S, Takemura S, Tanaka S, Kinoshita M, Hamano G, Nakanuma Y, Sato Y, Mimaki S, Tsuchihara K
  • Organizer: The 7th Asia-Pacific Primary Liver Cancer Expert Meeting
  • Place of Presentation: Hong Kong （China)
  • Int'l Joint Research
• [Presentation] 職業性肝内胆管癌と非職業性肝内胆管癌との臨床病理学的比較 (2016)
  • Author(s): 濱野玄弥，竹村茂一，田中肖吾，新川寛二，木下正彦，伊藤得路，青田尚哲，江田将樹，山本隆嗣，久保正二
  • Organizer: 第71回日本消化器外科学会総会
  • Place of Presentation: あわぎんホール、アスティ徳島(徳島件徳島市）
• [Presentation] 肝切除症例からみた肝内胆管癌と非アルコール性脂肪性肝炎の関連性 (2016)
  • Author(s): 木下正彦，竹村茂一，田中肖吾，濱野玄弥，伊藤得路，江田将樹，青田尚哲，田中さやか，大澤政彦，久保正二
  • Organizer: 第71回日本消化器外科学会総会
  • Place of Presentation: あわぎんホール、アスティ徳島(徳島件徳島市）
• [Presentation] 胆道癌に対するDUPAN-Ⅱ測定の有効性について (2016)
  • Author(s): 伊藤得路，竹村茂一，田中肖吾，木下正彦，濱野玄弥，青田尚哲，石原 敦，新川寛二，久保正二
  • Organizer: 第71回日本消化器外科学会総会
  • Place of Presentation: あわぎんホール、アスティ徳島(徳島件徳島市）
• [Presentation] 職業性胆管癌の手術成績 (2016)
  • Author(s): 木下正彦，竹村茂一，田中肖吾，新川寛二，濱野玄弥，伊藤得路，江田将樹，青田尚哲，久保正二
  • Organizer: 第14回日本消化器外科学会大会
  • Place of Presentation: 神戸国際会議場(兵庫県神戸市）
• [Presentation] 当科における職業性胆管癌切除症例の病理学的検討 (2015)
  • Author(s): 木下正彦，中沼安二，竹村茂一，佐藤保則，田中肖吾，新川寛二，西岡孝芳，濱野玄弥，伊藤得路，青田尚哲，江田将樹，久保正二
  • Organizer: 第13回日本消化器外科学会大会
  • Place of Presentation: グランドプリンスホテル新高輪（東京都港区）
  • Year and Date: 2015-10-08
• [Presentation] Carbon monoxide releasing molecule-3 (CORM-3) modulates progression of M1/M2 phenotypes in alveolar macrophages (2015)
  • Author(s): Yamamoto-Oka H, Mizuguchi S, Toda M,Izumi N, Okada S, Minamiyama Y,Takemura S, Cerpinskas G, Nishiyama N
  • Organizer: SFRR-E/SNFS Meeting Stuttgart 2015
  • Place of Presentation: シュトゥットガルト（ドイツ）
  • Year and Date: 2015-09-02
  • Int'l Joint Research
• [Presentation] Liver fibrosis is improved by treatment of S-allyl cysteine, an aged-garlic extract, in CCl4-treated rats (2015)
  • Author(s): Minamiyama Y, Takemura S, Kodai S, Kubo S, Mizuguchi S, Oka-Yamamoto H, Ichikawa H, Yoshikawa T
  • Organizer: SFRR-E/SNFS Meeting Stuttgart 2015
  • Place of Presentation: シュトゥットガルト（ドイツ）
  • Year and Date: 2015-09-02
  • Int'l Joint Research
• [Presentation] 肝内胆管癌の病態に立脚した治療戦略の現状 (2015)
  • Author(s): 竹村茂一，上西崇弘，田中肖吾，久保正二
  • Organizer: 第51回日本肝癌研究会
  • Place of Presentation: 神戸国際会議場(兵庫県神戸市）
  • Year and Date: 2015-07-23
• [Presentation] Local control of Laparoscopic hepatic resection for surface hepatocellular carcinoma: Comparison with percutaneous radiofrequency ablation (2015)
  • Author(s): Ito T, Tanaka S, Iwai S, Takemura S, Hagihara A, Uchida S, Sakae M, Hamano G, Kinoshita M, Koda M, Aota T, Kawada N, Kubo S
  • Organizer: The 6th Asia-Pacific Primary Liver Cancer Expert Meeting
  • Place of Presentation: ハイアットリージェンシー大阪（大阪府大阪市）
  • Year and Date: 2015-07-03
  • Int'l Joint Research
• [Presentation] Dissolution of liver fibrosis by S-allyl cysteine, an aged-garlic extract, in CC14-treated rats. (2015)
  • Author(s): Minamiyama Y, Takemura S, Kodai S, Kubo S, Azuma H, Osada-Oka M, Misumi K, Terao J, Ichikawa H
  • Organizer: 12th Asian Congress of Nutrition
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2015-05-14
  • Int'l Joint Research
• [Presentation] これまでの職業性胆管癌症例の検討-大阪での１７例と新規労災認定９例の比較- (2015)
  • Author(s): 木下正彦，中沼安二，竹村茂一，田中肖吾，新川寛二，西岡孝芳，濱野玄弥，伊藤得路，江田将樹，久保正二
  • Organizer: 第115回日本外科学会定期学術集会
  • Place of Presentation: 名古屋国際会議場(愛知県名古屋市）
  • Year and Date: 2015-04-16