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Experimental study for the clinical application of cryosurgery for pancreatic tumors

Research Project

Project/Area Number 15K10196
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Digestive surgery
Research InstitutionKeio University

Principal Investigator

Kitago Minoru  慶應義塾大学, 医学部(信濃町), 講師 (70296599)

Co-Investigator(Kenkyū-buntansha) 板野 理  慶應義塾大学, 医学部(信濃町), 講師(非常勤) (90265827)
Co-Investigator(Renkei-kenkyūsha) NAKATSUKA SEISHI  慶應義塾大学, 医学部, 講師 (50188984)
MATSUDA SACHIKO  慶應義塾大学, 医学部, 特任講師 (90534537)
ONISHI AKIRA  日本大学, 生物資源科学部, 教授 (30414890)
FUCHIMOTO DAIICHIRO  独立行政法人農業生物資源研究所, 主任研究員 (10343998)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords膵腫瘍 / 局所療法 / 凍結融解壊死療法 / 開腹手術 / 腹腔鏡下手術 / 膵炎 / 膵臓 / 大動物(ブタ) / 腹腔鏡
Outline of Final Research Achievements

The treatment of pancreatic tumor is mainly surgery. However, pancreatic resection involves a high perioperative complication rate. Cryoablation is a potentially less invasive locoregional ablation modality that has been used to treat malignancy in various organs. We conducted experiments to evaluate the efficacy and safety of this method.
The experiments included assessment of acute-phase response, procedural availability, and evaluation of postprocedural course. Cryoablation of porcine pancreas was technically practicable by both open and laparoscopic approaches. Histological findings proved that the pancreatic tissue was effectively necrotized by cryoablation and that the degree of necrosis was more severe in proportion to the distance from the freeze center. Serum amylase and lipase levels showed transient elevations shortly after the procedure, followed by rapid decrease to normal level, indicating that the cyroablation of the pancreas did not cause severe pancreatitis.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (2 results)

All 2017 2016

All Presentation (2 results)

  • [Presentation] ブタの膵臓を用いた凍結融解壊死療法の手技に関する基礎的実験2017

    • Author(s)
      今井俊一、北郷実
    • Organizer
      JDDW 2017
    • Related Report
      2017 Annual Research Report
  • [Presentation] The experimental study for procedural availability of cryoablation of pancreas in vivo using porcines2016

    • Author(s)
      今井俊一
    • Organizer
      第28回日本肝胆膵外科学会学術集会
    • Place of Presentation
      大阪国際会議場(大阪府大阪市)
    • Year and Date
      2016-06-02
    • Related Report
      2016 Research-status Report 2015 Research-status Report

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Published: 2015-04-16   Modified: 2019-03-29  

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