Investigation of pathogenic mechanisms for central post-stroke pain and its accompanying emotional disorder - evaluation of microglial activation hypothesis
| Project/Area Number |
15K10311
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurosurgery
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| Research Institution | Kagoshima University |
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Principal Investigator |
ARITA Kazunori 鹿児島大学, 医歯学域医学系, 教授 (90212646)
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| Co-Investigator(Kenkyū-buntansha) |
時村 洋 鹿児島大学, 医歯学総合研究科, 客員研究員 (50227568)
宮田 篤郎 鹿児島大学, 医歯学域医学系, 教授 (60183969)
栗原 崇 鹿児島大学, 医歯学域医学系, 准教授 (60282745)
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| Research Collaborator |
SADAMURA Yuko
SAMESHIMA Yoshimune
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 脳卒中後疼痛 / 視床痛 / ミクログリア / p38 MAPキナーゼ / 中枢神経障害性疼痛 / うつ様行動 / 不安様行動 / 電位依存性Caチャネル / 抑うつ行動 / 尾懸垂試験 / アロディニア / 脳卒中後情動異常 |
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| Outline of Final Research Achievements |
In this study, we have established experimental conditions that enabled us to measure both stable mechanical withdrawal thresholds of hindpaws and emotional behaviors of thalamic hemorrhage-induced central post-stroke pain model mice. We found that systemic administration of inhibitors for microglial activation including minocycline and p38 MAP kinase inhibitors significantly alleviated the expression of both thalamic hemorrhage-induced mechanical allodynia and increased locomotor activity. Furthermore, N-type voltage-gated Ca channels were suggested to contribute to the development of the thalamic hemorrhage-induced mechanical allodynia in the acute phase. In contrast, we have not yet detected significant thalamic hemorrhage-induced depression-like behaviors in both acute and subacute phases. Thus, further study is necessary for the detection of the depression-like behaviors.
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Report
(4 results)
Research Products
(9 results)
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[Journal Article] In silico screening identified novel small-molecule antagonists of PAC1 receptor.2018
Author(s)
Takasaki I, Watanabe A, Yokai M, Watanabe Y, Hayakawa, D, Nagashima, R, Fukuchi, M, Okada, T, Toyooka, N, Miyata, A, Gouda H, Kurihara T.
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Journal Title
J. Pharmacol. Exp. Ther.
Volume: -
Issue: 1
Pages: 1-8
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Dysfunctional GPR40/FFAR1 signaling exacerbates pain behavior in mice.2017
Author(s)
Nakamoto K, Aizawa F, Miyagi K, Yamashita T, Mankura M, Koyama Y, Kasuya F, Hirasawa A, Kurihara T, Miyata A, Tokuyama S.
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Journal Title
PLoS One
Volume: 12(7)
Issue: 7
Pages: e0180610-e0180610
DOI
Related Report
Peer Reviewed / Open Access
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