multidisciplinary analysis for severe spinal deformity including cervical kyphosis

• Project/Area Number: 15K10414
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Orthopaedic surgery
• Research Institution: Nagoya City University
• Principal Investigator: Mizutani Jun 名古屋市立大学, 大学院医学研究科, 准教授 (70326156)
• Co-Investigator(Kenkyū-buntansha): 大塚 隆信 名古屋市立大学, 大学院医学研究科, 教授 (10185316) ; 鈴木 伸幸 名古屋市立大学, 大学院医学研究科, 助教 (50551230) ; 松川 則之 名古屋市立大学, 大学院医学研究科, 教授 (20305543) ; 植木 美乃 名古屋市立大学, 大学院医学研究科, 講師 (40467478) ; 梅村 淳 順天堂大学, 医学(系)研究科(研究院), 先任准教授 (00244567)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2017: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2016: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000); Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 脊柱変形 / 低侵襲脊椎手術 / 頚椎後弯変形 / 脊柱配列 / パーキンソン病 / 低侵襲手術 / 成人脊柱変形 / MRI / 低侵襲化

Outline of Final Research Achievements

We elucidated that recently introduced minimally invasive lateral interbody fusion surgery minimize the invasiveness of adult spinal deformity surgery. In addition, in order to elucidate the pathological condition of severe cervical deformity. Etiology and pathophysiological status of the severe cervical deformity has not been fully gained consensus. We, for the first time, elucidated the relatinship between total spinal balance and cervical kyphosis. We also examined whether cervical deformity surgery affects total spinal alignment or not. The primary goal of cervical reconstruction surgery is to achieve occiputtrunk concordance. Once it is achieved, subsequent thoracolumbar alignment changes occur as needed to harmonize global spinal alignment. Cervical reconstruction can restore both cervical deformity and global spinal alignment.

Research Products

• [Int'l Joint Research] University of California San Francisco(米国)
• [Int'l Joint Research] University of California, San Francisco(米国)
• [Journal Article] How Cervical Reconstruction Surgery Affects Global Spinal Alignment (2018)
  • Author(s): Mizutani Jun、Strom Russell、Abumi Kuniyoshi、Endo Kenji、Ishii Ken、Yagi Mitsuru、Tay Bobby、Deviren Vedat、Ames Christopher
  • Journal Title: Neurosurgery Volume: 印刷中 Issue: 4 Pages: 898-907
  • DOI: 10.1093/neuros/nyy141
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Advantages of an on-the-screwhead crosslink connector for atlantoaxial fixation using the Goel/Harms technique (2018)
  • Author(s): Mizutani Jun、Inada Atsushi、Kato Kenji、Kondo Akira、Kainuma Shingo、Fujita Kazuhiko、Yagi Kiyoshi、Shimamura Yasuteru、Fukuoka Muneyoshi、Shibamoto Yuta、Wada Ikuo、Otsuka Takanobu
  • Journal Title: Journal of Clinical Neuroscience Volume: 50 Pages: 183-189
  • DOI: 10.1016/j.jocn.2018.01.043
  • Peer Reviewed
• [Journal Article] Global Spinal Alignment in Cervical Kyphotic Deformity: The Importance of Head Position and Thoracolumbar Alignment in the Compensatory Mechanism (2017)
  • Author(s): Mizutani Jun、Verma Kushagra、Endo Kenji、Ishii Ken、Abumi Kuniyoshi、Yagi Mitsuru、Hosogane Naobumi、Yang Jeffrey、Tay Bobby、Deviren Vedat、Ames Christopher
  • Journal Title: Neurosurgery Volume: 82 Issue: 5 Pages: 686-694
  • DOI: 10.1093/neuros/nyx288
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Global spinal alignment in cervical kyphotic deformity: the importance of head position and thoraco-lumbar alignment in the compensatory mechanism. (2017)
  • Author(s): Mizutani J, Verma K, Endo K, Ishii K, Abumi K, Yagi M, Hosogane N, Yang J, Tay B, Deviren V, Ames C.
  • Journal Title: Neurosurgery. Volume: 印刷中
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Presentation] 頚椎後弯変形における全脊柱バランストと頭蓋ポジション (2017)
  • Author(s): 水谷潤、遠藤健司、鐙邦芳、石井賢、八木満、細金直文、大塚隆信、和田郁雄、C.Ames
  • Organizer: 第90回日本整形外科学会学術総会
  • Place of Presentation: 仙台国際センター 他（宮城県、仙台市）
  • Year and Date: 2017-05-18
• [Presentation] 重度頚椎後弯変形再建術後の全脊柱バランスの変化 (2017)
  • Author(s): 水谷潤、鐙邦芳、石井賢、八木満、遠藤健司、大塚隆信、和田郁雄、C.Ames
  • Organizer: 第90回日本整形外科学会学術総会
  • Place of Presentation: 仙台国際センター 他（宮城県、仙台市）
  • Year and Date: 2017-05-18
• [Presentation] 頚椎後弯変形における全脊柱バランスの特徴と頚椎後弯変形矯正手術後の胸 腰椎アライメント変化 (2017)
  • Author(s): 水谷潤
  • Organizer: 第46回日本脊椎脊髄病学会学術集会
  • Place of Presentation: ロイトン札幌 他（北海道、札幌市）
  • Year and Date: 2017-04-13
• [Presentation] 頚椎後弯変形における全脊柱バランスの特徴と頚椎後弯変形矯正手術後の胸 腰椎アライメ ント変化 (2017)
  • Author(s): 水谷潤
  • Organizer: 第46回日本脊椎脊髄病学会学術集会
• [Presentation] 頚椎後弯変形における全脊柱バランストと頭蓋ポジション (2017)
  • Author(s): 水谷潤、遠藤健司、鐙邦芳、石井賢、八木満、細金直文、大塚隆信、 和田郁雄、C.Ames
  • Organizer: 第90回日本整形外科学会学術総会
• [Presentation] 重度頚椎後弯変形再建術後の全脊柱バランスの変化 (2017)
  • Author(s): 水谷潤、鐙邦芳、石井賢、八木満、遠藤健司、大塚隆信、和田郁雄、 C.Ames
  • Organizer: 第90回日本整形外科学会学術総会
• [Presentation] Thoracolumbar Reciprocal Changes after Cervical Reconstructive Surgery. (2016)
  • Author(s): Jun Mizutani, Russell Glenn Strom, Kuniyoshi Abumi, Kenji Endo, Ken Ishii, Mitsuru Yagi, Kushagra Verma, Bobby Tay, Vedat Deviren, Christopher P. Ames.
  • Organizer: 51st Annual Meeting & Course of Scoliosis Research Society (SRS)
  • Place of Presentation: Prague, Czech Republic
  • Year and Date: 2016-09-21
  • Int'l Joint Research
• [Presentation] Thoraco-Lumbar reciprocal changes after cervical reconstruction surgery (2016)
  • Author(s): Jun Mizutani, Russell Strom, Kenji Endo, Kuniyoshi Abumi, Ken Ishii, Mitsuru Yagi, Bobby Tay, Vedat Deviren, Christopher Ames
  • Organizer: Scoliosis Research Society
  • Place of Presentation: Prague, Czech Republic
  • Year and Date: 2016-09-21
  • Int'l Joint Research
• [Presentation] Theoraco Lumbar Reciprocal Changes after Cervical Spine Reconstruction. (2016)
  • Author(s): Jun Mizutani, Russell Strom, Kushagra Verma, Kenji Endo, Ken Ishii, Kuniyoshi Abumi, Mitsuru Yagi, Bobby Tay, Vedat Deviren, Christopher Ames.
  • Organizer: 32nd Annual Meeting of the European Section of the Cervical Spine Research Society (CSRS 2016)
  • Place of Presentation: Prague, Czech Republic
  • Year and Date: 2016-05-11
  • Int'l Joint Research
• [Presentation] Compensation mechanism in thoraco-lumbar segments in patients with symptomatic primary cervical kyphosis (2016)
  • Author(s): Jun Mizutani, Kushagra Verama, Kenji Endo, Kuniyoshi Abumi, Ken Ishii, Mitsuru Yagi, Bobby Tay, Vedat Deviren, Christopher Ames
  • Organizer: Cervical Spine Research Society European Section
  • Place of Presentation: Prague, Czech Republic
  • Year and Date: 2016-05-11
  • Int'l Joint Research
• [Presentation] Compensation mechanism in thoraco-lumbar segments in patients with symptomatic primary cervical kyphosis (2016)
  • Author(s): Jun Mizutani, Kenji Endo, Kuniyoshi Abumi, Ken Ishii, Mitsuru Yagi, Bobby Tay, Vedat Deviren, Christopher Ames
  • Organizer: American Association of Neurological Surgeons
  • Place of Presentation: Chicago, USA
  • Year and Date: 2016-04-30
  • Int'l Joint Research
• [Presentation] Relationship between psoas muscle position and spin-pelvic parameters: an analysis using magnetic resonance imaging (2016)
  • Author(s): Akira Kondo, Yuichiro Abe, Jun Mizutani, Shigenobu Sato, Kentaro Yamada, Takanobu Otsuka
  • Organizer: 9th Annual SOLAS research meeting
  • Place of Presentation: San Diego, USA
  • Year and Date: 2016-03-21
  • Int'l Joint Research
• [Presentation] 成人脊柱変形の低侵襲化 (2015)
  • Author(s): 水谷 潤、福岡宗良、鈴木伸幸、大塚聖視、大塚隆信
  • Organizer: 第88回日本整形外科学会学術総会
  • Place of Presentation: 神戸ポートピアホテル他（兵庫県・神戸市）
  • Year and Date: 2015-05-21